Results 51 to 60 of about 5,008,934 (241)

[Transport of drugs through human erythrocyte membranes. Change of transport by introduction of amino group or amino acids in benzoic acid].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1990
The transporting properties of benzoic acid (BA) and its derivatives such as hippuric acid (HPA), p-aminohippuric acid (AHPA), N-benzoyl-beta-alanine (NBA), p-amino-N-benzoyl-beta-alanine (ANBA), N-benzoyl-6-aminocaproic acid (NBC), p-amino-N-benzoyl-6 ...
Y. Matsumoto, M. Ohsako
semanticscholar   +1 more source

Glutamate cycling may drive organic anion transport on the basal membrane of human placental syncytiotrophoblast

, 2015
The organic anion transporter OAT4 (SLC22A11) and organic anion transporting polypeptide OATP2B1 (SLCO2B1) are expressed in the basal membrane of the placental syncytiotrophoblast.
Brooks, S., Cleal, J., Hanson, M., Lewis, R., Lofthouse, Emma, O'Kelly, Ita, Poore, K.   +6 more
core   +1 more source

Assessment of Potential Drug–Drug Interactions for Novel Oral Melanocortin‐1 Receptor Agonist Dersimelagon

Pharmacology Research &Perspectives, Volume 13, Issue 1, February 2025.
ABSTRACT Dersimelagon is a novel investigational orally administered selective agonist of the melanocortin‐1 receptor. The drug–drug interaction (DDI) potential of dersimelagon was investigated in both nonclinical (in vitro) and clinical studies. The in vitro inhibition of CYP/UGT isoforms and efflux/uptake transporters by dersimelagon was assessed ...
Akihito Ogasawara, Ryosuke Ide, Shinsuke Inoue, Minoru Tsuda, Renli Teng   +4 more
wiley   +1 more source

A Statistically Rigorous Test for the Identification of Parent−Fragment Pairs in LC-MS Datasets [PDF]

, 2010
Untargeted global metabolic profiling by liquid chromato-graphy−mass spectrometry generates numerous signals that are due to unknown compounds and whose identification forms an important challenge.
Chakraborty A., Chernushevich I. V., Coates P., Du P., Griffiths W., Hoffmann E., Katajamaa M., Larntz K., Lommen A., Luedemann A., Metz T. O., Nicholson J. K., O’Connor P., Plumb R., Przyborowski J., Raamsdonk L. M., Rockwood A., Smith C. A., Smith C. A., Wackerly D. D., Want E. J., Wilson I. D., Wishart D. S., Wu Q.   +23 more
core   +2 more sources

Effects of patent foramen ovale in migraine: a metabolomics‐based study

The Journal of Physiology, Volume 603, Issue 4, Page 809-835, 15 February 2025.
Abstract figure legend Aura, cystatin‐C and calcium are biomarkers of PFO in migraine. PFO closure relieves migraine by regulating 5‐HT metabolism and redox reactions, especially in the posterior head. cTTE, contrast‐transthoracic echocardiography; DESI‐MSI, desorption electrospray ionization mass imaging; H&E, haematoxylin and eosin; PFO, patent ...
Bosi Dong, Xin Li, Lu Zhang, Ge Liang, Wen Zheng, Luolan Gui, Shuming Ji, Yusha Tang, Hua Li, Wanling Li, Ruiqi Yang, Yajiao Li, Anjiao Peng, Yucheng Chen, Meng Gong, Lei Chen   +15 more
wiley   +1 more source

Quantitative studies of the metabolism of chylomicron triglycerides and cholesterol by liver and extrahepatic tissues of sheep and dogs.

Journal of Clinical Investigation, 1971
Unanesthetized sheep and dogs, previously fitted with indwelling catheters in the aorta, lower vena cava, mesenteric, portal, left hepatic and jugular veins, were given constant intravenous infusions of lymph in which the chylomicron lipids were ...
E. N. Bergman, R. Havel, B. Wolfe, T. Bøhmer   +3 more
semanticscholar   +1 more source

Features, Causes and Consequences of Splanchnic Sequestration of Amino Acid in Old Rats [PDF]

, 2011
RATIONALE: In elderly subjects, splanchnic extraction of amino acids (AA) increases during meals in a process known as splanchnic sequestration of amino acids (SSAA).
A Tourianyjf, B Pennings, BJ Merry, BJ Merry, C Brun, C Felgines, CG Beliveau, CG Proud, Christian Aussel, CJ Lynch, CS Katsanos, D Albani, D Dardevet, D Dardevet, D Gallagher, D Paddon-Jones, DF Goldspink, E Curis, E Volpi, E Volpi, EJ Barrett, FL Shinnick, GA Borkan, GA Ten Have, GB Forbes, GP Frick, GP Frick, H Lochs, HM van Eijk, HM van Eijk, J Rosenblatt, JA Morais, JE Morley, K Kumagai, K Pailla, KL Timmerman, KS Nair, L Cynober, LA Schaap, LS Jefferson, Luc Cynober, M Cesari, M Iannuzzi-Sucich, M Jourdan, Marion Jourdan, MJ Bruins, MJ Hardonk, MM Hallemeesch, Nicolaas E. P. Deutz, P Fleury, P Schauder, R Roubenoff, RM Rai, S Welle, SN Hilmer, Stephane Blanc, TI Rao, Y Boirie, Y Boirie   +58 more
core   +3 more sources

Flux of amino acids and peptides across the portal vein-drained tissue of pigs

, 1999
An experiment was carried out to determine the flux of amino acids across the portal vein-drained tissue into and out of the plasma and red blood cell free amino acid pools and the plasma peptide pool of the portal vein blood of growing pigs.
W. Caine, M. Verstegen, W. Sauer, S. Tamminga, P. V. Leeuwen   +4 more
semanticscholar   +1 more source

Tyramine as a prolific coformer in crystal engineering : insights from classical crystal structure analysis and electron density studies [PDF]

Prolific coformers are compounds that readily form multicomponent crystals with diverse partners, playing a crucial role in crystal engineering by enabling the creation of new solids with enhanced physicochemical properties.
Grabowski, Szymon, Gryl, Marlena
core   +2 more sources

Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies. [PDF]

, 2019
Variation in steroid hormone levels has wide implications for health and disease. The genes encoding the proteins involved in steroid disposition represent key determinants of interindividual variation in steroid levels and ultimately, their effects ...
Boerwinkle, Eric, Cheung, Kit Wun Kathy, Chien, Huan-Chieh, Feofanova, Elena V, Giacomini, Kathleen M, Irannejad, Roshanak, Kinchen, Jason M, Stecula, Adrian, Suhre, Karsten, van Borselen, Marjolein, Yee, Sook Wah, Yousri, Noha A, Yu, Bing, Zou, Ling   +13 more
core   +2 more sources