dissertationThe effect of pretreatment with penicillin on para-aminohippurate (PAH) transport by kidney of the immature rat was evaluated in vivo.
Noordewier, Byron
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Carnosine uptake in rat choroid plexus primary cell cultures and choroid plexus whole tissue from PEPT2 null mice [PDF]
PEPT2 is functionally active and localized to the apical membrane of rat choroid plexus epithelial cells. However, little is known about the transport mechanisms of endogenous neuropeptides in choroid plexus, and the role of PEPT2 in this process. In the
Chung-Hwang E.+11 more
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Substrate Stimulation of P-Aminohippuric Acid Transport: Effect on Uptake and Runout
The ability of penicillin pretreatment to increase PAH accumulation by slices of newborn rabbit renal cortex was dissected into two components, uptake and runout. The oxygen-requiring component of the uptake process was significantly enhanced by penicillin treatment, whereas runout was unaffected.
W. R. Hewitt, Jerry B. Hook, D. G. Pegg
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Renal secretion of diphosphonates in rats [PDF]
Renal secretion of diphosphonates in rats. Diphosphonates, characterized by a P—C—P bond, are relatively new experimental drugs used for the treatment of myositis ossificans, dental calculus, nephrolithiasis and Paget's disease.
Bonjour, Jean-Philippe+2 more
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The distribution of p-aminohippuric acid in rat kidney slices. I. Tubular localization
The distribution of p-aminohippuric acid in rat kidney slices. I. Tubular localization. Tubular localization of tritiated p-aminohippuric acid (PAH) was determined by section freeze-dry autoradiography in rat renal cortical slices in vitro. Autoradiographs were also prepared from tissue after incubation in tritiated alpha-aminoisobutyric acid (AIB ...
Richard P. Wedeen, Barry Weiner
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Chemical assay of p-aminohippuric acid simplified by use of dimethylaminocinnamaldehyde in ethanol.
Abstract We have developed a new and simple method of p-aminohippuric acid determination by use of dimethylaminocinnamaldehyde (DACA). It differs from previous methods using DACA in that the reaction is carried out in ethanol rather than in dilute acid. This results in deeper and more stable color development.
Lewis B. Schwartz+2 more
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Autoregulation of ketogenesis in fasted sheep [PDF]
The effects of beta-hydroxybutyrate at rates simulating maximum utilization on portal-drained viscera (PDV), hepatic (HEP), and hindquarter (rump) net fluxes of acetoacetate (AcAc), beta-hydroxybutyrate (BOHB), free fatty acids (FFA), insulin (IN) and ...
Dawes, Dianne J.
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The change of p-aminohippuric acid disposition kinetics accompanied by growth in mice.
The change of disposition kinetics for p-aminohippuric acid (PAH) was studied following intravenous administration of p-[glycyl-1-14C]aminohippuric acid to 1-day-old, 1-week-old, 3-week-old and 8-week-old mice. The expiratory excretion of 14CO2 in 24 h following the administration was almost negligible in 1-day-old and 1-week-old mice in contrast to 3 ...
Junji Hirate+3 more
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The distribution of p-aminohippuric acid in rat kidney slices. II. Depth of uptake
The distribution of p-aminohippuric acid in rat kidney slices. II. Depth of uptake. Section freeze-dry autoradiography was used to measure the depth to which concentrative uptake of PAH-3H occurs within rat renal cortical slices in vitro under conditions of varied incubation time, temperature and PAH medium concentration.
Richard P. Wedeen, Barry Weiner
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Renal Basolateral Transport of Glucuronides and Other Organic Anions in Rat in Vitro Models [PDF]
Glucuronidation is a common Phase II biotransformation reaction that increases the hydrophilicity, and thus elimination, of toxins, xenobiotics, and endogenous compounds.
Miles, Sarah L.
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