β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor [PDF]
Cell Reports, 2018 Summary: Exercise has beneficial effects on metabolism and on tissues. The exercise-induced muscle factor β-aminoisobutyric acid (BAIBA) plays a critical role in the browning of white fat and in insulin resistance. Here we show another function for BAIBA,
Yukiko Kitase +8 more
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Dynamic of lipid droplets and gene expression in response to β-aminoisobutyric acid treatment on 3T3-L1 cells [PDF]
European Journal of Histochemistry, 2018 Research on adipobiology has recognized the browning process of white adipocytes as a potential therapeutic strategy for the treatment of obesity and related morbidities.
Monica Colitti +2 more
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Urinary N-methylnicotinamide and β-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children. [PDF]
Sci Rep, 2016 Mayneris-Perxachs J +10 more
europepmc +6 more sources
Enhanced L-β-Aminoisobutyric Acid Is Involved in the Pathophysiology of Effectiveness for Treatment-Resistant Schizophrenia and Adverse Reactions of Clozapine [PDF]
Biomolecules, 2023 Clozapine is an effective antipsychotic for the treatment of antipsychotic-resistant schizophrenia; however, specific types of A/B adverse effects and clozapine-discontinuation syndromes are also well known.
Kouji Fukuyama +2 more
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Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill [PDF]
Frontiers in Endocrinology, 2023 Signaling metabolites can effectively regulate the biological functions of many tissues and organs. β-Aminoisobutyric acid (BAIBA), a product of valine and thymine catabolism in skeletal muscle, has been reported to participate in the regulation of lipid,
Xuejie Yi +7 more
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Elevated circulating level of β-aminoisobutyric acid (BAIBA) in heart failure patients with type 2 diabetes receiving sodium-glucose cotransporter 2 inhibitors [PDF]
Cardiovascular Diabetology, 2022 Aims The mechanism by which a sodium-glucose cotransporter inhibitor (SGLT2i) induces favorable effects on diabetes and cardiovascular diseases including heart failure (HF) remains poorly understood.
Satoshi Katano +15 more
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Genetic loci of beta-aminoisobutyric acid are associated with aging-related mild cognitive impairment [PDF]
Translational Psychiatry, 2023 We studied the genetic associations of a previously developed Metabolomic Risk Score (MRS) for Mild Cognitive Impairment (MCI) and beta-aminoisobutyric acid metabolite (BAIBA)—the metabolite highlighted by results from a genome-wide association study ...
Einat Granot-Hershkovitz +11 more
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A Novel Gliotransmitter, L-β-Aminoisobutyric Acid, Contributes to Pathophysiology of Clinical Efficacies and Adverse Reactions of Clozapine [PDF]
Biomolecules, 2023 Clozapine is listed as one of the most effective antipsychotics and has been approved for treating treatment-resistant schizophrenia (TRS); however, several type A and B adverse reactions, including weight gain, metabolic complications, cardiotoxicity ...
Kouji Fukuyama +2 more
doaj +2 more sources
β-Aminoisobutyric Acid Relates to Favorable Glucose Metabolism through Adiponectin in Adults with Obesity Independent of Prediabetes [PDF]
Journal of Diabetes Research, 2023 β-Aminoisobutyric acid (BAIBA) is secreted by skeletal muscle and promotes insulin sensitivity, fat oxidation, and anti-inflammation. While BAIBA is purportedly lower in individuals with obesity, no work has examined if prediabetes (PD) differentially ...
Habiba Faiz +2 more
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Application of α-aminoisobutyric acid and β-aminoisobutyric acid inhibits pericarp browning of harvested longan fruit. [PDF]
Chem Cent J, 2015 Pericarp browning is a critical problem resulting in reduced commercial value and shelf life of longan fruit.Two non-protein amino acids, α-aminoisobutyric acid (AIB) and β-aminoisobutyric acid (BAIB) at 100 and 1 mM were applied to longan fruit prior to storage for up to 8 days at 25 °C respectively.
Wang H, Zhi W, Qu H, Lin H, Jiang Y.
europepmc +4 more sources