Associations between plasma branched-chain amino acids, β-aminoisobutyric acid and body composition [PDF]
Journal of Nutritional Science, 2016 Plasma branched-chain amino acids (BCAA) are elevated in obesity and associated with increased cardiometabolic risk. β-Aminoisobutyric acid (B-AIBA), a recently identified small molecule metabolite, is associated with decreased cardiometabolic risk ...
Annemarie Rietman +6 more
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Both enantiomers of β-aminoisobutyric acid BAIBA regulate Fgf23 via MRGPRD receptor by activating distinct signaling pathways in osteocytes [PDF]
Cell ReportsSummary: With exercise, muscle and bone produce factors with beneficial effects on brain, fat, and other organs. Exercise in mice increased fibroblast growth factor 23 (FGF23), urine phosphate, and the muscle metabolite L-β-aminoisobutyric acid (L-BAIBA),
Eijiro Sakamoto +9 more
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Acute Aerobic Exercise Leads to Increased Plasma Levels of R- and S-β-Aminoisobutyric Acid in Humans [PDF]
Frontiers in Physiology, 2019 Recently, it was suggested that β-aminoisobutyric acid (BAIBA) is a myokine involved in browning of fat. However, there is no evidence for an acute effect of exercise supporting this statement and the metabolic distinct enantiomers of BAIBA were not ...
Jan Stautemas +7 more
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β‑aminoisobutyric acid ameliorates hypertensive vascular remodeling via activating the AMPK/SIRT1 pathway in VSMCs. [PDF]
Bioengineered, 2022 Yin B, Wang YB, Li X, Hou XW.
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DL-3-Aminoisobutyric acid: vibrational, NBO and AIM analysis of N–H⋯O bonded-zwitterionic dimer model [PDF]
Heliyon, 2019 A zwitterionic dimer model constructed of inter-molecular –N–H⋯O bonding has been proposed for the solid sample of DL-3-Aminoisobutyric acid consistent with IR absorption and Raman spectral features measured in the 3500–400/50 cm−1.
Shashikala Yalagi +2 more
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β-aminoisobutyric acid attenuates LPS-induced inflammation and insulin resistance in adipocytes through AMPK-mediated pathway [PDF]
Journal of Biomedical Science, 2018 Background β-aminoisobutyric acid (BAIBA) is produced in skeletal muscle during exercise and has beneficial effects on obesity-related metabolic disorders such as diabetes and non-alcoholic fatty liver disease.
Tae Woo Jung +4 more
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Chemoenzymatic synthesis of polypeptides containing the unnatural amino acid 2-aminoisobutyric acid
Chemical Communications, 2017 Polypeptides containing 2-aminoisobutiryc acid (Aib) as an unnatural amino acid were synthesized via chemoenzymatic polymerization of the tripeptide ethyl ester AlaAibAla-OEt.
Kousuke, Tsuchiya, Keiji, Numata
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Remote Conformational Control of a Chloride‐Binding Site
ChemistryEuropePeptide foldamers, each with a stereogenic C‐terminal bis(squaramide) separated from an N‐terminal amino acid “controller” by an α‐aminoisobutyric acid (Aib) tetramer, have been shown to bind chloride.
Rhodri Ll. Evans +6 more
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Effect of Introducing Leucine Residues into 2‑Aminoisobutyric Acid-Based Amphiphilic Helical Peptides on Intermolecular Interactions and Peptide Self-Assembly. [PDF]
ACS OmegaYamaguchi K +6 more
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Journal of Pharmacological Sciences, 2017 Renal fibrosis is a hallmark feature of chronic kidney disease, which is reflected by proliferation and migration of interstitial fibroblasts and extracellular matrix (ECM) accumulation.
Huijuan Wang +4 more
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