Results 71 to 80 of about 9,324 (253)

Analyzing Nicotine Action Against Amyloid Toxicity by NMR‐Pharmacometabolomics: An Exploratory Study

NMR in Biomedicine, Volume 39, Issue 4, April 2026.
Combined metabolomic analysis of the intracellular and extracellular portions of SH‐SY5Y cells revealed that, in the presence of Aβ 1–42, nicotine primarily influences pathways related to neurotransmission, energy metabolism, as well as the biosynthesis and degradation of membrane phospholipids.
Enza Napolitano, Carmen Marino, Manuela Grimaldi, Michela Buonocore, Angelo Santoro, Anna Maria D'Ursi   +5 more
wiley   +1 more source

The Ethylene Precursor ACC Affects Early Vegetative Development Independently of Ethylene Signaling

Frontiers in Plant Science, 2019
The plant hormone ethylene plays a pivotal role in virtually every aspect of plant development, including vegetative growth, fruit ripening, senescence, and abscission. Moreover, it acts as a primary defense signal during plant stress.
Lisa Vanderstraeten, Thomas Depaepe, Sophie Bertrand, Dominique Van Der Straeten   +3 more
doaj   +1 more source

The cationic tetradecapeptide mastoparan as a privileged structure for drug discovery: Enhanced antimicrobial properties of mitoparan analogues modified at position-14 [PDF]

, 2018
Mastoparan (MP) peptides, distributed in insect venoms, induce a local inflammatory response post envenomation. Most endogenous MPs share common structural elements within a tetradecapeptide sequence that adopts an amphipathic helix whilst traversing ...
Howl, John, Howl, Lewis, Jones, Sarah
core   +1 more source

Measuring blood–brain barrier dysfunction: a critical appraisal of fluid biomarkers, in vitro models, in vivo imaging, and post‐mortem approaches

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract The blood–brain barrier (BBB) maintains central nervous system homeostasis by regulating molecular exchange between blood and brain. BBB dysfunction is associated with aging and neurological disorders such as Alzheimer's disease, stroke, and multiple sclerosis.
Shakira A. van der Panne, Helena Durrant, Jannis F. Heuer, Ivana Kancheva, Arno Stellingwerf, Lieuwe T. K. M. Verkaar, Damon Verstappen, Pascalle Mossel, Walter H. Backes, Erik N. T. P. Bakker, Jurgen A. H. R. Claassen, Marcel M. Verbeek, Louise van der Weerd, Matthias J. P. van Osch, Helga E. de Vries   +14 more
wiley   +1 more source

Quantum chemical study of molecular properties of small branched-chain amino acids in water

Amino Acids
Four aliphatic amino acids—α-aminobutyric acid (AABA), β-aminobutyric acid (BABA), α-aminoisobutyric acid (AAIBA) and β-aminoisobutyric acid (BAIBA) were investigated in water as a solvent by two quantum chemical methods.
Roman Boča, Žofia Rádiková, Juraj Štofko, Beata Vranovičová, Cyril Rajnák   +4 more
doaj   +1 more source

Longitudinal Physical Activity Change During Hemodialysis and Its Association With Body Composition and Plasma BAIBA Levels

Frontiers in Physiology, 2019
Rationale: Low physical activity is frequent in end stage renal disease. We evaluated the longitudinal change in physical activity and its barriers in hemodialysis (HD) patients and the association between the patterns of physical activity change, body ...
Alessio Molfino, Maria Ida Amabile, Maria Ida Amabile, Thomas Ammann, Silvia Lai, Alessandra Grosso, Luana Lionetto, Alessandra Spagnoli, Maurizio Simmaco, Massimo Monti, Alessandro Laviano, Maria Grazia Chiappini, Maurizio Muscaritoli   +12 more
doaj   +1 more source

Turn‐Induction in Peptides Incorporating Novel Cyrene‐Derived α,α‐Disubstituted Amino Acid

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
Novel chiral cyrene‐derived Cyr residues were incorporated into peptides. The α,α‐disubstituted amino acid residue was introduced using the Ugi reaction. X‐ray crystallographic analysis of R‐ and S‐Cyr residues indicated preference to adopt left‐ and right‐handed α‐helical conformations, respectively.
Kajumee Bora Bhowal, Raphael Hitti, William D. Lubell   +2 more
wiley   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, Volume 22, Issue 16, 17 March 2026.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Differential diagnosis of (inherited) amino acid metabolism or transport disorders [PDF]

, 1992
__Abstract__ Disorders of amino acid metabolism or transport are most clearly expressed in urine. Nevertheless the interpretation of abnormalities in urinary amino acid excretion remains difficult. An increase or decrease of almost every amino acid in
Blom, W.A.M. (Wim), Huijmans, J.G.M. (Jan)   +1 more
core   +7 more sources

EPR of Gamma Irradiated Nα -Monochloroacetyl-α-Aminoisobutyric Acid

Zeitschrift für Naturforschung A, 2004
Electron paramagnetic resonance of γ -irradiated single crystals of Nα -monochloroacetyl-α-aminoisobutyric acid were investigated at room temperature and 130 K. The paramagnetic center as attributed to the (CH3)2 ˙CCOOH radical.
Baskan, MH, Osmanoglu, S
openaire   +1 more source