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Transport of ?-aminoisobutyric acid in mammalian pancreatic �-cells

Diabetologia, 1971
Transport of α-aminoisobutyric acid (AIB) was studied in microdissected pancreatic islets of obesehyperglycaemic mice. These islets are characterized by an unusually high proportion of insulin-secretingβ-cells. The following main observations were made. 1. The islet cells exhibited a concentrative uptake of AIB, yielding distribution ratios much higher
B, Hellman, J, Sehlin, I B, Täljedal
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NAP Alpha-Aminoisobutyric Acid (IsoNAP)

Journal of Molecular Neuroscience, 2013
We set out to identify NAP (davunetide) analogs, providing neuroprotection and reducing tau pathology, specifically addressing protection against protein misfolding. NAP (NAPVSIPQ, intranasal formulation AL-108) is a drug candidate that (1) had a statistically significant impact on two measures, namely digit span and delayed-match-to-sample, tests of ...
Illana, Gozes   +4 more
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DL-3-Aminoisobutyric Acid Monohydrate

Acta Crystallographica Section C Crystal Structure Communications, 1998
The title acid, 3-amino-2-methylpropanoic acid monohydrate, C4H9NO2.H2O, crystallized in the centrosymmetric space group Pbca in the zwitterionic form. The three H atoms on N, which are involved in hydrogen bonding, are ordered. The three intermolecular N-H...O hydrogen bonds have N...O distances ranging from 2.758 (2) to 2.809 (2) A and N-H...O angles
A J, Dobson, R E, Gerkin
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Bradykinin analogs containing α-aminoisobutyric acid (Aib)

Peptides, 1980
All seven possible bradykinin (BK) analogs contained Aib in place of proline have been synthesized by the solid phase method and assayed for in vitro myotropic activity on the guinea pig ileum and rat uterus, and in vivo on the rat blood pressure, both in intravenous and intra-aortic administration. [Aib(2,3)]-BK, [Aib(2,7)]-BK, and [Aib(2,3,7)]-BK had
R J, Vavrek, J M, Stewart
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