Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moiety. [PDF]
PLoS ONE, 2011 BACKGROUND: Redox cycling compounds have been reported to cause false positive inhibition of proteases in drug discovery studies. This kind of false positives can lead to unusually high hit rates in high-throughput screening campaigns and require further
Bojana Mirković +3 more
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Results in Chemistry, 2022 Nitrogen containing heterocyclic compounds such as benzoxazole derivatives have been found to be pharmacologically active and are being employed as starting material for several drug discovery researches.
Jyoti Sharma +2 more
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Synthesis and evaluation of halogenated nitrophenoxazinones as nitroreductase substrates for the detection of pathogenic bacteria [PDF]
, 2013 The synthesis and microbiological evaluation of 7-, 8- and 9-nitro-1,2,4-trihalogenophenoxazin-3-one substrates with potential in the detection of nitroreductase-expressing pathogenic microorganisms are described.
Alexandre F. Bedernjak +6 more
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Polymer testing, 2019 In this article, copper (II) oxide (CuO) nanomaterial was synthesized by a quick microwave heating method from the basic pH copper sulfate solution and mixed with agar (AG) biopolymer powder aqueous suspension to make the AG-CuO nanocomposite hydrogel ...
T. Kamal
semanticscholar +1 more source
Mannich base-connected syntheses mediated by ortho-quinone methides
Beilstein Journal of Organic Chemistry, 2018 This article provides an overview about specifically modified Mannich reactions where the process involves an ortho-quinone methide (o-QM) intermediate.
Petra Barta +2 more
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Molecules, 2005 The phenyliodonium ylide of 2-hydroxy-1,4-naphthoquinone reacts with aminoesters, ureas, aminoalcohols and aminophenols in refluxing dichloromethane to afford good yields of indanedione 2-carboxamido compounds, that in solution exist in an enol-amide ...
Spyros Spyroudis +2 more
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Synthetic, Spectroscopic and DFT Studies of Iron Complexes with Iminobenzo(semi)quinone Ligands: Implications for o-Aminophenol Dioxygenases [PDF]
, 2013 The oxidative CC bond cleavage of o-aminophenols by nonheme Fe dioxygenases is a critical step in both human metabolism (the kynurenine pathway) and the microbial degradation of nitroaromatic pollutants. The catalytic cycle of o-aminophenol dioxygenases (
Bittner, Michael M. +4 more
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019 Aminophenols, which are widely used as components of hair dye and medicine, may function as environmental endocrine disruptors by regulating the proliferation of endocrine-related cancers.
Lin Wang +6 more
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A Synthetic Model of the Putative Fe(II)-Iminobenzosemiquinonate Intermediate in the Catalytic Cycle of \u3cem\u3eo\u3c/em\u3e-Aminophenol Dioxygenases [PDF]
, 2012 The oxidative ring cleavage of aromatic substrates by nonheme Fe dioxygenases is thought to involve formation of a ferrous–(substrate radical) intermediate.
Bittner, Michael M. +2 more
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Hydrogenation of nitrobenzene to 4-aminophenol in a fully reusable solvent system, by using Pt, Rh, Pd supported on carbon-CF3COOH catalytic system [PDF]
, 1990 4-Aminophenol is an important raw material for several products in the field of dyes, photographs and pharmaceutics. For instance, paracetamol (N-acetyl-4-aminophenol) a widely employed analgesic and antipyretic whose production is in continuous growth ...
Andrews +19 more
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