Results 61 to 70 of about 72,335 (302)

Machine learning methods for predicting adverse drug events: A systematic review

British Journal of Clinical Pharmacology, EarlyView.
Abstract Predicting adverse drug events (ADEs) in outpatient settings is crucial for improving medication safety, identifying high‐risk patients and reducing health‐care costs. While traditional methods struggle with the complexity of health‐care data, machine learning (ML) models offer improved prediction capabilities; however, their effectiveness in ...
Niaz Chalabianloo, Fatemeh Ahmadi, Mohammad Ali Omrani, Sheikh S. Abdullah, Neda Rostamzadeh, Atefeh Jafari, Lujain Izzedin, Kamran Sedig, Flory T. Muanda   +8 more
wiley   +1 more source

L-Carnitine Ameliorates Amiodarone-Mediated Alveolar Damage: Oxidative Stress Parameters, Inflammatory Markers, Histological and Ultrastructural Insights

Pharmaceuticals
The aim of this study was to assess L-carnitine’s effects on adult male rats’ lung damage brought on by amiodarone, which is a potent antiarrhythmic with limited clinical efficacy due to potentially life-threatening amiodarone-induced lung damage ...
Samy A. Dawood, Ali Alsuheel Asseri, Ayed A. Shati, Refaat A. Eid, Basiouny El-Gamal, Mohamed Samir A. Zaki   +5 more
doaj   +1 more source

Too Little, Too Late: A Case of a Swift Fatal Culmination of Amiodarone Induced Pulmonary Toxicity in an Adult Male

International Medical Case Reports Journal, 2023
Clement Tan, Pranav Kumar Department of Respiratory Medicine, Mackay Base Hospital, Mackay, Queensland, AustraliaCorrespondence: Clement Tan; Pranav Kumar, Email Clement.Tan@health.qld.gov.au; Pranav.Kumar@health.qld.gov.auAbstract: Amiodarone is a ...
Tan C, Kumar P
doaj  

Comparative effectiveness and safety of oral anticoagulants in patients with atrial fibrillation using antiarrhythmic drugs: An international cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aim Our international cohort study assessed the comparative effectiveness and safety of direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs) among patients with non‐valvular atrial fibrillation (NVAF) using antiarrhythmic drugs. Methods Using the United Kingdom's (UK's) Clinical Practice Research Datalink Aurum and Québec claims data, we
Fabian Maximilian Meinert, Jenny Dimakos, Ying Cui, Kristian B. Filion, Christel Renoux, Antonios Douros   +5 more
wiley   +1 more source

Lipid composition and dynamics of cell membranes of Bacillus stearothermophilus adapted to amiodarone [PDF]

, 2000
Bacillus stearothermophilus, a useful model to evaluate membrane interactions of lipophilic drugs, adapts to the presence of amiodarone in the growth medium.
Antunes-Madeira, Maria do Carmo, Jurado, Amália S., Madeira, Vítor M. C., Matos, Manuel J., Rosa, Sónia M. L. J.   +4 more
core   +1 more source

Amiodarone in the aged [PDF]

Australian Prescriber, 2019
Amiodarone is a highly effective antiarrhythmic drug, but can have serious adverse effects, particularly in older patients. If possible it should not be used purely for controlling the heart rate If a prescription for amiodarone is contemplated, particularly for an older patient, consult a cardiologist.
Srinivasan, Meera, Ahmad, Laura, Bhindi, Ravinay, Allahwala, Usaid   +3 more
openaire   +2 more sources

A Streamline Strategy for Indication and Length of Telemetry Monitoring After TAVR

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Both indication and length of ECG telemetry monitoring (TM) after transcatheter aortic valve replacement (TAVR) are not well defined. Aims We hypothesize that a targeted strategy for monitoring conductive disorders (CD) post‐TAVR can reduce the need and duration of in‐hospital TM without compromising safety. Methods We prospectively
Antonin Fournier, Pierre Robert, Benoit Lattuca, Claire Duflos, Maël‐Morvan Duroyon, Jean‐Christophe Macia, Laurent Schmutz, Matthieu Steinecker, Jean‐Michel Berdeu, Thomas Gandet, Jean Luc Pasquie, François Roubille, Guillaume Cayla, Florence Leclercq   +13 more
wiley   +1 more source

Optimal model‐based design of experiments for parameter precision: Supercritical extraction case

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract This study investigates the process of chamomile oil extraction from flowers. A parameter‐distributed model consisting of a set of partial differential equations is used to describe the governing mass transfer phenomena in a cylindrical packed bed with solid chamomile particles under supercritical conditions using carbon dioxide as a solvent ...
Oliwer Sliczniuk, Pekka Oinas
wiley   +1 more source

Variable radiographic and histologic presentations of amiodarone‐related interstitial lung disease and the importance of avoiding re‐exposure

Respirology Case Reports, 2023
Amiodarone is a commonly used antiarrhythmic agent but exhibits potential pulmonary toxicity. In this case series, we describe the clinical, radiographic, and histologic manifestations of three patients who developed interstitial lung disease (ILD ...
I‐Lin Tsai, Li‐Ting Huang, Yu‐Ting Yu, Chung‐Ta Lee, Tang‐Hsiu Huang   +4 more
doaj   +1 more source

Clinical Implementation of Pharmacogenomics and Drug–Drug Interaction Screening in a German Academic Teaching Hospital and Outpatient Follow‐Up

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of the implemented pharmacogenomics (PGx) process in clinical routine at the Robert Bosch Hospital: from patient enrollment via the hospital information system, DNA detection using a customized TaqMan OpenArray panel and qPCR for CNV assessment, to clinical translation of genotyping results into PGx guideline‐based recommendations using a ...
Roman Tremmel, Filippa Schreeck, Simon Jaeger, Severin Schricker, Elke Schaeffeler, Svitlana Igel, Daniela Steinberger, Manuel Pagitz, Jörg Latus, Markus Ketteler, Kerstin Bühl, Marc‐H. Dahlke, Hans‐Georg Kopp, Matthias Schwab   +13 more
wiley   +1 more source