Results 121 to 130 of about 42,887 (227)

Risk of gastrointestinal bleeding by specific SSRIs and SNRIs: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, Volume 92, Issue 3, Page 793-808, March 2026.
Aim The purpose of this study is to estimate the risk of gastrointestinal bleeding (GIB) by selective serotonin reuptake inhibitors (SSRIs) and serotonin–norepinephrine reuptake inhibitors (SNRIs) individual agents. Methods A systematic review was conducted for each unique antidepressant (i.e.
Ainhoa Gomez‐Lumbreras, Abdelrahman G. Tawfik, Guilherme Del Fiol, Kensaku Kawamoto, Thomas Reese, Katy Trinkley, Aubrey Jones, James Mitchell, Daniel C. Malone   +8 more
wiley   +1 more source

Deconstructing lipid emulsion binding of amitriptyline: potential significance for phospholipid emulsifier

Toxicology Communications
Background Lipid emulsion (LE) consists of soybean or other oil emulsified with phospholipid. We explored relative binding effects of LE, phospholipid liposomes (PLL), and soy oil (Soy).Methods We added 4 micrograms of amitriptyline to seven different 10 
Grant Cave, Justin Koh, Debra Chalmers, Michael Park, Martyn Harvey   +4 more
doaj   +1 more source

Effects of antidepressants on parameters, melondiadehyde, and diphenyl-2-picryl-hydrazyl levels in mice spermatozoa

International Journal of Reproductive BioMedicine, 2018
Background: Prescribing antidepressant drugs is becoming common. These drugs are known to affect sexual functions. Objective: The study is aimed to assess the effects of amitriptyline and venlafaxine on sperm parameters and evaluate Malondialdehyde (MDA)
Ladan Bandegi, Morteza Anvari, Mahmood Vakili, Arezoo Khoradmehr, Aghdas Mirjalili, Ali Reza Talebi   +5 more
doaj  

Restoring Oral Hygiene Autonomy Through a Customized Toothbrush Handle in a Patient With Rheumatoid Arthritis and Fibromyalgia

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Early identification of functional limitations in patients with rheumatoid arthritis (RA) and fibromyalgia (FM) is essential, as chronic joint pain and reduced dexterity often impair basic oral hygiene practices. This case highlights a simple, cost‐effective, and reproducible intervention using a customized soft putty toothbrush handle ...
Khalid Alfaifi, Ali Robaian, Abdulaziz alsakr, Wael Alanazi, Abdullah Saad Alqahtani   +4 more
wiley   +1 more source

Is osteopathic manipulation effective for headaches? [PDF]

, 2008
Spinal manipulative therapy (SMT), a component of osteopathy, has been shown to be variably effective for the treatment of headaches. For the prophylactic treatment of cervicogenic headaches and for acute tension headaches, SMT is superior to placebo ...
Keays, Ashley C., Neher, Jon O., Safranek, Sarah   +2 more
core  

SMPD1 as a Potential Prognostic Biomarker in Glioma Is Associated With an Immunosuppressive Microenvironment

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
SMPD1 expression varies across different glioma subtypes and clinical features and is associated with poor prognosis. High SMPD1 levels are linked to an immunosuppressive tumor microenvironment, characterized by suppressed M1 macrophage polarization and enhanced M2‐like signatures.
Yanan Xu, Xing Liu, Boya Xu, Qiuling Li, Luofei Zhang, Cao Li, Zhigang Zhao   +6 more
wiley   +1 more source

Evaluation of the effect of locally administered amitriptyline gel as adjunct to local anesthetics in irreversible pulpitis pain

Indian Journal of Dental Research, 2009
Background: Amitriptyline is one of the most common tricyclic antidepressants, which binds to pain sensory nerve fibers close to the sodium channel; hence, it could interact to some degree with receptors of local anesthetics.
Moghadamnia A, Partovi M, Mohammadianfar I, Madani Z, Zabihi E, Hamidi M, Baradaran M   +6 more
doaj  

The Association of Antidepressant Medication and Body Weight Gain [PDF]

, 2013
Objective: To review the literature and discover which antidepressants are responsible for weight gain and then to discuss the areas with lack of adequate knowledge.
Deng, Chao, Pai, Nagesh Brahmavar, Ranjbar, Sara   +2 more
core   +2 more sources

Single‐Dose Pharmacokinetic Assessment of TNX‐102 SL (Cyclobenzaprine HCl Sublingual Tablets): Results From Randomized, Open‐Label Studies in Healthy Volunteers

Clinical Pharmacology in Drug Development, Volume 15, Issue 3, March 2026.
Abstract Daily oral cyclobenzaprine hydrochloride (HCl) has provided transient benefits in fibromyalgia, a chronic pain condition. To improve this effect, we evaluated sublingual formulations designed to drive transmucosal absorption. Two open‐label studies evaluated the pharmacokinetics (PK), tolerability, and relative bioavailability of sublingual ...
Bruce L Daugherty, Bernd Meibohm, Gregory M Sullivan, Errol M Gould, Seth Lederman   +4 more
wiley   +1 more source

Prescription Trends and Clinical Decision‐Making in Neuropathic Pain Pharmacological Treatment: Results From a Cross‐Sectional Survey by the Spanish Pain Society

European Journal of Pain, Volume 30, Issue 3, March 2026.
ABSTRACT Background Neuropathic pain (NP) is a complex chronic condition with limited therapeutic effectiveness. Despite multiple drug classes and international guidelines, real‐world adherence remains inconsistent, and data on prescribing practices among pain specialists is scarce. Methods We conducted a nationwide cross‐sectional survey among members
Miguel Á. Huerta, Mónica Mayo‐Moldes, Miguel M. Garcia, Beliu García‐Parra, Mercè Matute, Yolanda López‐Tofiño, Nancy Paniagua, Mar Hernández‐Secorún, Dolors Soler, Marcos Salmerón, Julian Taylor, Enrique Verdú, José A. Valencia, Silvia Pico, Clara Díaz‐Alejo, Masahito Katsuki, Ancor Serrano‐Afonso, M. Carmen Ruiz‐Cantero   +17 more
wiley   +1 more source