Results 131 to 140 of about 29,828 (259)

Comparison the Pain Relief of Amitriptyline Mouthwash with Benzydamine in Oral Mucositis

Journal of Dentistry, 2018
Statement of the Problem: A significant proportion of patients undergoing chemotherapy or radiotherapy suffer from mucositis. The first symptom of oral mucositis is pain. Severe pain, burning sensation, and discomfort in the oral cavity make it difficult
Shahla Kakoei , Abbas Pardakhty , Maryam-Al-Sadat Hashemipour , Hasan Larizadeh , Behjat Kalantari , Elaheh Tahmasebi   +5 more
doaj  

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Psychometric Properties of the Choosing Wisely Questions in a Large Psychiatric Sample

International Journal of Methods in Psychiatric Research, Volume 35, Issue 4, December 2026.
ABSTRACT Objectives The Choosing Wisely Questions (CWQ) support shared decision‐making and aim to reduce low‐value care, but their psychometric properties remain unclear. This study evaluated the structural validity, reliability, and item characteristics of the Swedish CWQ in a psychiatric sample.
Johan Bengtsson, Alma Andersson, Natalie Forss Lilja, Isabella Hultgren Farsani, Ellen Lissbrant, Björn Wettermark, Ida Blomqvist   +6 more
wiley   +1 more source

Amitriptyline v. the rest: still the leading antidepressant after 40 years of randomised controlled trials

, 2001
Background Tricyclic antidepressants have similar efficacy and slightly lower tolerability than selective serotonin reuptake inhibitors (SSRls). However, there are no systematic reviews assessing amitriptyline, the reference tricyclic drug, v.
Barbui, C, Hotopf, M
core   +1 more source

Repetitive transcranial magnetic stimulation for depression after colorectal cancer treatment with chemotherapy‐induced peripheral neuropathy: A case report

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 4, December 2026.
Abstract Background Treatment of depression in patients with cancer requires individualized decision‐making considering physical symptoms, drug interactions, adverse effects, treatment burden, and acceptability. We report a patient with persistent depression after colorectal cancer treatment, in whom pharmacotherapy was constrained by insufficient ...
Kosei Esaki, Takeo Saito, Yuki Matsuda, Yueren Zhao, Hiroyuki Kimura, Masashi Ikeda, Tsuyoshi Kitajima, Nakao Iwata   +7 more
wiley   +1 more source

Chronic Scrotal Content Pain: A Practical Guide to Diagnosis and Management

Trends in Urology &Men's Health, Volume 17, Issue 6, December 2026.
ABSTRACT Chronic scrotal content pain (CSCP) is a common but often poorly understood condition that presents a significant diagnostic and therapeutic challenge. The broad differential diagnosis and frequent absence of an identifiable cause can lead to repeated investigations, delayed treatment and unnecessary surgery.
Mahin Chowdhury, Mohammad Arabiyat, Ibrahim Abuelbeh, Theodora Stasinou, Peter Grice, Vaibhav Modgil, Ian Pearce   +6 more
wiley   +1 more source

Experimental comparative study of the analgesic activity of the diurnal anxiolytic mebicar, amitriptyline, and diazepam

, 2020
It is established that mebicar, amitriptyline, and diazepam administered intraperitoneally at therapeutic doses increase the pain thresholds in mice as manifested in "hot plate" analgesia test. Mebicar was more effective than diazepam and not inferior to
Ziganshina L., Khaziakhmetova V., Luchai K.   +2 more
core  

A Re‐Appraisal of Three Network Meta‐Analyses to Explain the Discrepancy in Findings for the Efficacy of Fluoxetine for the Treatment of Depression in Children and Adolescents

Cochrane Evidence Synthesis and Methods, Volume 4, Issue 6, November 2026.
ABSTRACT Objective To explain discrepant findings for fluoxetine's efficacy in three influential network meta‐analyses (NMAs) of treatments for pediatric depression, which led to conflicting clinical recommendations. Design Critical appraisal and re‐analysis of three published NMAs.
Richard Lyus, Florian Naudet, Gert van Valkenhoef, Martin Plöderl   +3 more
wiley   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1338-1347, November 2026.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia, Giusy Carleo, Zhenni Yang, Francesca Di Matteo, Federica De Rosa, Gerardina Smaldone, Zhao‐Bing Gao, Marco D'Alì, Rita Turcio, Demin Ma, Veronica Di Sarno, Nannan Su, Salvatore Vincenzo Giofrè, Giacomo Pepe, Pietro Campiglia, Alessia Bertamino, Francesco Miceli, Jiangtao Guo, Nunzio Iraci, Carmine Ostacolo, Maurizio Taglialatela   +20 more
wiley   +2 more sources