Results 141 to 150 of about 161,793 (289)

Vitexin Attenuates the Growth and Glycolysis of Acute Myeloid Leukemia Cells by Suppressing the HIF‐1α‐Modulated YAP Pathway Under Hypoxic Conditions

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Vitexin, an apigenin flavone glycoside, exhibits antitumor activity against various cancers including leukemia. Hypoxia enhances glycolysis, thereby promoting tumor growth. In this study, we aimed to explore the effects of vitexin on hypoxia‐induced growth and glycolysis in acute myeloid leukemia (AML) cells and determine the underlying ...
Ping Wang, Jia‐Jia Zhang, Fang Zhang, Xiao‐Jie Qu, Hui Zhang   +4 more
wiley   +1 more source

Prediction of myeloid malignant cells in Fanconi anemia using machine learning. [PDF]

PLoS One
Flores-Mejía LA, Siliceo P, Figueroa UJ, De la Cruz AA, Ayala-Zambrano C, Tovar H, Frías S, Rodríguez A.   +7 more
europepmc   +1 more source

Deficit accumulation frailty index and treatment tolerability in AML: data from CALGB 11001 and 11002 (Alliance) [PDF]

Catherine Lai, Minji Lee, Olivia Bobek, Jennifer Le‐Rademacher, Sumithra J. Mandrekar, Gail J. Roboz, Geoffrey L. Uy, Jeanne S. Mandelblatt, Heidi D. Klepin   +8 more
openalex   +1 more source

Beyond PD‐1/PD‐L1: New Immune Checkpoints and Therapeutic Combinations in Cancer Immunotherapy

Medicine Bulletin, EarlyView.
ABSTRACT Recently, immune checkpoint inhibitors (ICIs), particularly PD‐1/PD‐L1 and CTLA‐4 inhibitors, have revolutionized cancer treatment, significantly improving survival rates for various malignancies. However, ICI therapies targeting single checkpoints on T cells still face numerous challenges, such as low response rates and post‐treatment ...
Yangyang Li, Zizhen Kang, Yanyun Du
wiley   +1 more source

Next-generation CAR-T therapy for acute myeloid leukemia: bridging innovation with clinical translation. [PDF]

Ann Hematol
Zhao X, Ming X, Wu J, Zhu X, Xiao Y.
europepmc   +1 more source

Brain Imaging Changes Following Deep Brain Stimulation Patients with Parkinson's Disease: A Literature Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's Disease (PD) is a progressive neurodegenerative disorder primarily characterized by motor symptoms such as tremors, rigidity, and bradykinesia. Structural brain changes, including atrophy in the midbrain, basal ganglia, and cortical regions such as the frontal and temporal lobes, are observed in advanced stages.
Suraiya Mangra, Stanislaw Szlufik, Chao‐Kai Hu, Alexandre Boutet, Jürgen Germann, Andres M. Lozano   +5 more
wiley   +1 more source

Highly effective combination of BRG1/BRM inhibitor with BET inhibitor or decitabine for high-risk MECOM-rearranged AML. [PDF]

Hemasphere
Fiskus W, Mill CP, Piel J, Collins M, Hentemann M, Cuglievan B, Birdwell CE, Das K, Davis JA, Hou H, Jain A, Malovannaya A, Flores LB, Kadia TM, Daver N, Sasaki K, Takahashi K, Hammond D, Wang J, Loghavi S, Su X, DiNardo CD, Delwel R, Bhalla KN.   +23 more
europepmc   +1 more source

The Global Burden of Leukemia, 1990–2021: A Systematic Analysis of Prevalence, DALYs, and Risk Factors From the Global Burden of Disease Study

Med Research, EarlyView.
Using data from the Global Burden of Disease Study 2021, we systematically assessed leukemia prevalence and disability‐adjusted life years (DALYs) across 204 countries and territories from 1990 to 2021, stratified by subtype, demographics, and risk factors.
Yuping Wu, Haini Zhang, Shuang Luo, Xiangmei Zhang, Mei Tan, Jinmei Chen, Pei Huang, Yan Chen, Zuochen Du   +8 more
wiley   +1 more source

KIT Mutant/Core binding factor-negative acute myeloid leukemia might be a complex subgroup with dismal prognosis: a single-center retrospective analysis. [PDF]

Ann Hematol
Jiang R, Zhang Z, Liu Y, Qu W, Zeng Z, Wang L, Wang Q, Yin J, Chen S.   +8 more
europepmc   +1 more source

Beta‐Band and Aperiodic Activity Across New and Chronic Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Neurophysiological biomarkers in Parkinson's disease (PD) are increasingly used for deep brain stimulation (DBS). Their long‐term utility is not clear, especially when transitioning to sensing‐guided DBS years post‐surgery. Objectives Beta‐band power, bursting activity, and periodic and aperiodic components of local field potentials
Arjun Balachandar, Alexandra Boogers, Sara Naghdlou, Andres M. Lozano, Suneil K. Kalia, Gerd Tinkhauser, Alfonso Fasano   +6 more
wiley   +1 more source