Results 151 to 160 of about 161,793 (289)

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi   +2 more
wiley   +1 more source

PRDM16 expression is an independent prognostic factor in AML with the double-mutant NPM1/FLT3-ITD genotype. [PDF]

open access: yesAnn Hematol
Stasik S   +16 more
europepmc   +1 more source

Leukemia in Older Adults: Global, National, and Regional Disease Burden Patterns During 1990–2019 and Forecasted Trends to 2030

open access: yesMedicine Advances, EarlyView.
After analyzing the burden of leukemia in the elderly aged 60–89 years from 1990 to 2019 using the Global Burden of Disease database, we found that although the burden of chronic myeloid leukemia has decreased over the past 30 years, the burden of other types of leukemia has continued to increase to varying degrees.
Jing Wei, Qijian Feng, Ziyuan Lu
wiley   +1 more source

Bio-adsorbent for wastewater treatment: amination of green coconut husk waste-derived lignin for the removal of Congo red dye. [PDF]

open access: yesRSC Adv
Bhuiyan RH   +8 more
europepmc   +1 more source

Meteorological versus spatial drivers of the spatial synchrony of forest insect pest outbreaks in North America

open access: yesOikos, EarlyView.
Spatial synchrony of population fluctuations has major consequences for the impacts of forest insect pest outbreaks at regional scales. We tested the predictions that the strength and drivers of this synchrony would differ among species according to their dispersal abilities and feeding guilds.
Kyle J. Haynes   +5 more
wiley   +1 more source

Gilteritinib in an Isolated CNS Recurrence of FLT3-ITD Positive AML. [PDF]

open access: yesClin Case Rep
Silva-Bermudez LS   +8 more
europepmc   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

open access: yesChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel   +5 more
wiley   +1 more source

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