AML and Ets proteins regulate the Iα1 germ-line promoter [PDF]
, 1999 Xiaoqi Xie +4 more
openalex +1 more source
Mechanisms of enhancer‐driven oncogene activation
International Journal of Cancer, EarlyView.Abstract An aggressive subtype of acute myeloid leukemia (AML) is caused by enhancer hijacking resulting in MECOM overexpression. Several chromosomal rearrangements can lead to this: the most common (inv(3)/t(3;3)) results in a hijacked GATA2 enhancer, and there are several atypical MECOM rearrangements involving enhancers from other hematopoietic ...
Joyce Vriend +2 more
wiley +1 more source
Clinical significance of surface antigen expression in children with acute myeloid leukemia: results of study AML-BFM-87 [PDF]
, 1995 Ursula Creutzig +8 more
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Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions
International Journal of Cancer, EarlyView.Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner +3 more
wiley +1 more source
Optimization of the indications for allogeneic stem cell transplantation in Acute Myeloid Leukemia based on interactive diagnostic strategies [PDF]
, 2011 The indications for allogeneic stem cell transplantation (SCT) in Acute Myeloid Leukemia (AML) represent a real challenge due to the clinical and genetic heterogeneity of the disorder.
Bacher, Ulrike +5 more
core
Enhancer‐dependent gene regulation in space, time, and malignancies
International Journal of Cancer, EarlyView.Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum +2 more
wiley +1 more source
Antipode, EarlyView., 2023 Abstract The perceptions and representations of whiteness around motherhood, family, and black sexuality reproduce the logic of what Hortense Spillers calls “captive flesh”, controlling understandings about femininity, motherhood, and gender. This debate is guided by the politics of the racial neoliberal agenda that works to control the urban ...
Danielle Pereira de Araújo
wiley +1 more source
G-CSF-mobilized PBSCT in children with AML in first complete remission [PDF]
, 1999 Luís Madero +3 more
openalex +1 more source
Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, EarlyView.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
GRIDVECTOR (version 1); an ARC/INFO AML program to extract linear features from a gray-scale image of a paper geologic map [PDF]
, 1997 Feliks M. Persits
openalex +1 more source