Results 41 to 50 of about 143,935 (260)

A pseudo-dynamic paradigm for reprogramming domain-wall-lattices in architected solids

Nature Communications
From Renaissance drapery to tissue morphogenesis, pattern formation exemplifies how geometry and constraints generate complex structures. In soft and architected matter, motifs such as creases, kinks, and domain walls function as order-parameter textures
Yafei Zhang, Yuan Zhou, Zhixuan Wen, Mingchao Liu, Chang Qing Chen   +4 more
doaj   +1 more source

On the origin of relapse in AML [PDF]

Science Translational Medicine, 2017
Preexisting therapy-resistant leukemia stem cell populations underlie the cellular origin of relapse in acute myeloid leukemia.
openaire   +4 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The Effects of Corrosive Media on Fatigue Performance of Structural Aluminum Alloys

Metals, 2016
The effects of corrosive media on rotating bending fatigue lives (the cyclic numbers from 104 to 108) of different aluminum alloys were investigated, which involved the corrosion fatigue lives of five kinds of aluminum alloys in air, at 3.5 wt. % and 5.0
Huihui Yang, Yanling Wang, Xishu Wang, Pan Pan, Dawei Jia   +4 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Enhancing haptic continuity in virtual reality using a continuity reinforcement skeleton

Nature Communications
Haptic displays are crucial for facilitating an immersive experience within virtual reality. However, when displaying continuous movements of contact, such as stroking and exploration, pixel-based haptic devices suffer from losing haptic information ...
Xinyuan Wang, Zhiqiang Meng, Chang Qing Chen   +2 more
doaj   +1 more source

Analysis of the Failure Modes in the Polymer Electrolyte Fuel Cell Cold-Start Process—Anode Dehydration or Cathode Pore Blockage

Energies, 2020
In this study, the cold-start failure processes of a polymer electrolyte fuel cell have been investigated numerically for different initial membrane water content λ 0 and the startup current densities I 0 .
Lei Yao, Fangfang Ma, Jie Peng, Jianbo Zhang, Yangjun Zhang, Jianpeng Shi   +5 more
doaj   +1 more source