Results 51 to 60 of about 143,935 (260)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Aerodynamic significance of mass distribution on diverse samara descent behaviors

Communications Engineering
Samaras, or wing seeds, feature fibrous appendages that act as wings to enable wind-driven dispersal. Diversity in morphologies and structures subtly contributes to the flight patterns of various seeds, thereby serving as a key factor in the reproductive
Zhao-Bang Hou, Jun-Duo Zhang, Yun-Da Li, Yong-Xia Jia, Wei-Xi Huang   +4 more
doaj   +1 more source

Two-dimensional modeling of the self-limiting oxidation in silicon and tungsten nanowires

Theoretical and Applied Mechanics Letters, 2016
Self-limiting oxidation of nanowires has been previously described as a reaction- or diffusion-controlled process. In this letter, the concept of finite reactive region is introduced into a diffusion-controlled model, based upon which a two-dimensional ...
Mingchao Liu, Peng Jin, Zhiping Xu, D.A.H. Hanaor, Yixiang Gan, C.Q. Chen   +5 more
doaj   +1 more source

Electron counting detectors in scanning transmission electron microscopy via hardware signal processing

Nature Communications, 2023
Transmission electron microscopy is a pivotal instrument in materials and biological sciences due to its ability to provide local structural and spectroscopic information on a wide range of materials.
Jonathan J. P. Peters, Tiarnan Mullarkey, Emma Hedley, Karin H. Müller, Alexandra Porter, Ali Mostaed, Lewys Jones   +6 more
doaj   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Estimated Import Demand Function for Pakistan: A Disaggregated Analysis

JISR Management and Social Sciences & Economics, 2015
The theme of the study was to estimate the elasticity of aggregated and selected disaggregated import demand function with relative prices and income for Pakistan from 1982 to 2011 on annual data.
Imran Ullah Khan Marwat
doaj  

Breaking the loop in AML

Blood, 2023
In this issue of Blood1, Bamezai et al reveal an unexpected, moonlighting* function of the germ cell associated RNA binding protein, PIWIL4 in AML. The authors show a tumor-specific requirement for PIWIL4 in R-loop homeostasis. Loss of PIWIL4 in AML cells led to uncontrolled R-loop formation, transcriptional stalling, DNA damage and an enhanced ...
openaire   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Molecular genetics of AML [PDF]

Best Practice & Research Clinical Haematology, 2012
In the past decade, a series of technological advances have revolutionized our ability to interrogate cancer genomes, culminating in whole-genome sequencing, which provides genome-wide coverage at a single base-pair resolution. To date, the tumor genome has been sequenced in nearly 40 cases of acute myeloid leukemia (AML).
openaire   +2 more sources