Results 71 to 80 of about 143,935 (260)
The role of the proteasome in AML
Blood Cancer Journal, 2016 AbstractAcute myeloid leukemia (AML) is deadly hematologic malignancy. Despite a well-characterized genetic and molecular landscape, targeted therapies for AML have failed to significantly improve clinical outcomes. Over the past decade, proteasome inhibition has been demonstrated to be an effective therapeutic strategy in several hematologic ...
Csizmar, C M, Kim, D-H, Sachs, Z
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Advanced Science, EarlyView.In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin +8 more
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Clustering of settling microswimmers in turbulence [PDF]
Nonlinear Processes in GeophysicsClustering of plankton plays a vital role in several biological activities, including feeding, predation, and mating. Gyrotaxis is one of the mechanisms that induces clustering.
J. Qiu +4 more
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Advanced Science, EarlyView.This perspective contrasts the historical, linear progression of early AI with the dynamic, iterative nature of AI 4.0; and it describes the real‐world medical applications and the necessary evolution of laboratory infrastructure brought about by AI 4.0.
Weida Liu, Gary Peltz
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Sensors, 2018 Multi-frequency scanning near-field optical microscopy, based on a quartz tuning fork-probe (QTF-p) sensor using the first two orders of in-plane bending symmetrical vibration modes, has recently been developed.
Xiaofei Zhang, Fengli Gao, Xide Li
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Advanced Science, EarlyView.Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan +7 more
wiley +1 more source
Advanced Intelligent Discovery, EarlyView.scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta +3 more
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Biology Open, 2015 Through natural selection, many animal organs with similar functions have evolved different macroscopic morphologies and microscopic structures. Here, we comparatively investigate the structures, properties and functions of honey bee stings and paper ...
Zi-Long Zhao +5 more
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POEMS Syndrome: 2026 Update on Diagnosis, Risk‐Stratification, and Management
American Journal of Hematology, EarlyView.ABSTRACT Disease Overview POEMS syndrome is a life‐threatening syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease.
Angela Dispenzieri
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AML: Predicting the Unpredictable [PDF]
Cell Stem Cell, 2018 Acute myeloid leukemia (AML) has been considered an unpredictable and unpreventable disease. Recently in Nature, Abelson et al. (2018) presented two models of AML risk prediction, one using the detection of high-risk age-related clonal hematopoiesis and the other using dynamic clinical attributes available from routine blood work.
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