Results 91 to 100 of about 334,593 (294)
Advanced Science, EarlyView.Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo +20 more
wiley +1 more source
Sensors, 2018 Multi-frequency scanning near-field optical microscopy, based on a quartz tuning fork-probe (QTF-p) sensor using the first two orders of in-plane bending symmetrical vibration modes, has recently been developed.
Xiaofei Zhang, Fengli Gao, Xide Li
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley +1 more source
Biology Open, 2015 Through natural selection, many animal organs with similar functions have evolved different macroscopic morphologies and microscopic structures. Here, we comparatively investigate the structures, properties and functions of honey bee stings and paper ...
Zi-Long Zhao +5 more
doaj +1 more source
The Impacts of the Chinese Anti-Monopoly Law on IP Commercialization in China & General Strategies for Technology-Driven Companies and Future Regulators [PDF]
, 2010 After thirteen years of discussion and three revisions, China\u27s Anti-Monopoly Law (AML) was promulgated on August 30, 2007 and has come into effect on August 1, 2008.
Tian, Yijun
core +1 more source
Advanced Science, EarlyView.ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs +4 more
wiley +1 more source
Advanced Intelligent Discovery, EarlyView.scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta +3 more
wiley +1 more source
Advanced Intelligent Systems, EarlyView.This study presents a novel framework that enhances the reliability of DNS traffic monitoring using a hybrid long short‐term memory‐deep neural network (LSMT‐DNN) architecture, enabling robust detection of adversarial DNS tunneling. The proposed framework leverages feature extraction from DNS traffic patterns, including domain request sequences, query ...
Ahmad Almadhor +5 more
wiley +1 more source
Mechanical Neural Networks with Explicit and Robust Neurons
Advanced ScienceMechanical computing provides an information processing method to realize sensing‐analyzing‐actuation integrated mechanical intelligence and, when combined with neural networks, can be more efficient for data‐rich cognitive tasks.
Tie Mei, Yuan Zhou, Chang Qing Chen
doaj +1 more source
American Journal of Hematology, EarlyView.ABSTRACT In a large multicenter real‐world cohort, we aimed to evaluate outcomes of FLAG‐Ida salvage therapy for relapsed/refractory (R/R) acute myeloid leukemia (AML) and validated the SALFLAGE prognostic score. We analyzed 1079 adults with R/R AML treated across 112 PETHEMA institutions over 26 years (1998–2024), including patients with primary ...
Gaspar Aspas Requena +49 more
wiley +1 more source