Results 131 to 140 of about 31,301 (226)

Amlodipine once-daily in systemic hypertension

, 1998
The calcium channel blocker nifedipine is widely used in children with systemic hypertension: however, because of the short duration of action, three to four daily doses of the standard preparation are required.
Busch, K., Truttmann, A. C., Bianchetti, M. G., Clericetti-Affolter, C., Laux-End, R., Pfammatter, J. P.   +5 more
core   +1 more source

Recent Advances in Intramolecular C─N Bond Formation for Pyrrolidine Synthesis

ChemistryOpen, Volume 15, Issue 6, June 2026.
This review highlights synthetic advances (2013–2025) in intramolecular C─N bond formation for constructing the pharmaceutically relevant pyrrolidine core. The review is organized into five methodological clusters: 1) intramolecular alkene/alkyne amination; 2) tandem annulations, which involve C─N bond formation as the key step; 3) nucleophilic ...
Rasma Kroņkalne, Māris Turks
wiley   +1 more source

Intravenous Tolvaptan Sodium Phosphate Can Fail to Improve Fluid Overload Due to Heart Failure in Patients With Chronic Kidney Disease: A Case Report

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Tolvaptan is widely used as an adjunct oral diuretic to loop and thiazide diuretics for the management of fluid overload in patients with congestive heart failure. Recently, tolvaptan sodium phosphate (TSP), a water‐soluble prodrug of tolvaptan, was developed for intravenous administration and has demonstrated efficacy and safety in clinical ...
Takaya Uno, Ichiro Nakakura, Akari Ikeda, Atsuki Hosoda, Yutaro Mukai, Kaori Yamanishi, Naohiro Ohara, Kaori Imanishi, Yoshiko Une, Satoshi Yokoyama, Kouichi Hosomi   +10 more
wiley   +1 more source

Pharmacogenomic Study of Selected Genes Affecting Amlodipine Blood Pressure Response in Patients with Hypertension

Asif Jan,1,2 Abdullah R Alanzi,3 Ramzi A Mothana,3 Jun-Ya Kaimori,4 Syed Shaukat Ali,5 Tahir Muhammad,6,7 Muhammad Saeed,8 Rani Akbar,9 Mehtab Khan10 1Department of Pharmacy, University of Peshawar, Peshawar, 25000, Pakistan; 2District Headquarter ...
Alanzi AR, Mothana RA, Akbar R, Khan M, Kaimori JY, Jan A, Muhammad T, Saeed M, Ali SS   +8 more
core  

The development of type 2 diabetes amongst sibling pairs in the South‐South region of Nigeria: The effect of genetics, environment and lifestyle

Diabetic Medicine, Volume 43, Issue 6, June 2026.
Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye, Ibi Erekosima, Adrian H. Heald, Gesiye Bozimo, Simon G. Anderson, Samuel Seidu, Kariba Akhidue, Adaeze Ugwu, Chioma Unachukwu, Ibitrokoemi Korubo, Kingsley Chukwuemeka Patrick‐Iwuanyanwu, Victoria Gomba, Uwoma Batubo, Victoria Akanatei, Victor Ken‐Uba, Iyeopu Siminialayi, Sokiprim Akoko, Justin Ideozu, Hamilton Opurum   +18 more
wiley   +1 more source

A Real-World Study on the Short-Term Efficacy of Amlodipine in Treating Hypertension Among Inpatients

Tingting Wang,1 Juntao Tan,2 Tiantian Wang,2 Shoushu Xiang,2 Yang Zhang,1 Chang Jian,1 Jie Jian,1 Wenlong Zhao1,3 1College of Medical Informatics, Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 2Operation Management Office ...
Jian C, Tan J, Zhang Y, Wang T, Xiang S, Zhao W, Jian J   +6 more
core  

Proposed photodegradation pathway of amlodipine.

, 2014
Proposed photodegradation pathway of amlodipine.
Anna Jakimska (639447), Piotr Nagórski (639449), Jacek Namieśnik (576937), Magdalena Śliwka-Kaszyńska (639448), Agata Kot-Wasik (639450)   +4 more
core   +1 more source

Fixed‐Dose Combinations for Hypertension: Barriers to Use and Opportunities for Health Systems

The Journal of Clinical Hypertension, Volume 28, Issue 6, June 2026.
ABSTRACT Background: Uncontrolled hypertension is a leading driver of heart disease, chronic kidney disease, heart failure, dementia, stroke, and pregnancy‐related complications. Fixed‐dose combinations (FDCs) are guideline‐endorsed first‐line therapies that improve blood pressure control by reducing pill burden, improving adherence, and targeting ...
Pranay Narang, Josselyne Marquez, Neema Rashidi, Rohini Haar, Sandeep P. Kishore   +4 more
wiley   +1 more source

Triple combination therapy with amlodipine, valsartan, and hydrochlorothiazide vs dual combination therapy with amlodipine and hydrochlorothiazide for stage 2 hypertensive patients

, 2010
Maurizio Destro1, Nora Crikelair2, Joseph Yen2, Robert Glazer 1Azienda Ospedaliera della Provincia di Pavia, Stradella (PV), Italy; 2Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USAObjective: This post hoc analysis evaluated ...
Nora Crikelair, Maurizio Destro, Joseph Yen, et al.   +3 more
core  

The Determinants of Negotiated Pharmaceutical Prices

The Journal of Industrial Economics, Volume 74, Issue 2, Page 234-260, June 2026.
ABSTRACT We focus on the determinants of pharmaceutical drug prices. Using data from the Brazilian pharmaceutical market, we find large variations in drug prices across buyers, drug classes, and time periods. Our estimation results provide evidence that transaction‐specific determinants between buyers and sellers (e.g., transaction volume, buyer's ...
Ralph B. Siebert, Sebastian Linde, Brandon Norton   +2 more
wiley   +1 more source