Results 61 to 70 of about 10,335 (286)

Resolution of Key Roles for the Distal Pocket Histidine in Cytochrome c Nitrite Reductases [PDF]

, 2015
Cytochrome c nitrite reductases perform a key step in the biogeochemical N-cycle by catalyzing the six-electron reduction of nitrite to ammonium. These multi-heme cytochromes contain a number of His/His ligated c-hemes for electron transfer and a ...
Burlat, Benedicte, Butt, Julea, Cheesman, Myles, Clarke, Tom, Kern, Melanie, Lockwood, Colin, Richardson, David, Simon, Jorg   +7 more
core   +5 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Changes in Biochemical Activity of Podzolic Chernozem under the Influence of Buckwheat Cultivation in the Conditions of Traditional and Organic Farming Systems [PDF]

, 2017
Проведено дослідження та виявлено зміни біологічної активності чорнозему опідзоленого Лісостепу України при вирощуванні гречки, як основної сільськогосподарської культури так і культури попередника за показниками ферментативної активності і процесів ...
Tsygichko, Ganna
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Bacterivorous Nematodes Drive Ammonification and Bacterial Community Growth in a Strongly Acidic Soil

Journal of Sustainable Agriculture and Environment
Nematodes, the most abundant animals on Earth, play a vital role in the soil biosphere by regulating microbial communities and influencing nutrient cycling.
Shuo Na, Helen L. Hayden, Ji‐Zheng He, Zi‐Yang He, Reza Ghaderi, Li Bi, Hang‐Wei Hu   +6 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Urea Coated with Iron and Zinc Oxide Nanoparticles Reduces Nitrogen Leaching in Sandy Soil and Improves the Performance of Young Corn Plants

Nitrogen
Nitrogen (N) is the most widely used nutrient in agriculture in the form of urea, yet it is one of the least efficient in terms of application due to losses through volatilization and leaching.
Cleiton Farias de Oliveira, Romildo da Silva Neves, Thiago Filipe de Lima Arruda, Sabrina dos Santos Costa, Railene Hérica Carlos Rocha Araújo, Ronaldo do Nascimento, Alexandre Paiva da Silva, Francisco Vaniés da Silva Sá, Josinaldo Lopes Araujo Rocha   +8 more
doaj   +1 more source

Modification of DRAINAGE Model by Using the Nitrogen Component from the GLEAMS Model [PDF]

, 1995
The NITRO subroutine of the DRAINAGE model (Kanwar et al., 1983) was modified using the nitrogen transformation components of the GLEAMS (Leonard et al., 1987) model to predict more accurately the leaching of NO3-N to subsurface drainage water. Predicted
Kanwar, Rameshwar, Kanwar, Rameshwar, Tim, U. Sunday, Tim, U. Sunday, Verma, Ashok   +4 more
core   +3 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source