Results 191 to 200 of about 190,766 (251)

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

Microalgae Hybrid Biosystem for Enhanced Oral Delivery of Rifaximin in Hepatic Encephalopathy Treatment

Advanced Science, EarlyView.
The microalgae‐nanoparticle hybrid system with antibacterial activity can improve the oral delivery and therapeutic efficiency for hepatic encephalopathy treatment. Oral administration of the system can reduced systemic ammonia levels, enhanced intestinal barrier function, attenuated systemic and neuroinflammation, ameliorated cognitive impairments ...
Kaiyue Wang, Xueting Huang, Lingxiao Yang, Jin Liu, Lei Lei, Shaomin Zou, Kai Wang, Min Zhou, Zhe Tang   +8 more
wiley   +1 more source

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

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Influence of ammonium nitrate on the crystallisation of ammonium sulfate

Environmental Technology, 2023
This study aims to explore the influence mechanism of ammonium nitrate produced by ozone denitrification on the crystallisation of ammonium sulfate, a by-product of ammonia desulfurisation. The laser method was used to study the influence of ammonium nitrate on the solubility and metastable zone width of ammonium sulfate. An experiment on the influence
Bangfu Huang, Meng Dai, Zhenjing Wen, Wanjun Li, Gaoyong Zi, Liubin Luo, Zhe Shi, Linjing Yang   +7 more
openaire   +2 more sources

The vapor phase dissociation of ammonium salts: Ammonium halides, ammonium rhodanide, ammonium nitrate, and ammonium bicarbonate

The Journal of Chemical Physics, 1982
Vapor pressures as a function of temperature of the ammonium salts are measured by means of a simultaneous torsion effusion and mass-loss effusion technique. From a theoretical analysis, which is given first, it is shown that the enthalpies of sublimation and the degree of dissociation b in the vapor phase are related to the measured quantities.
openaire   +1 more source

Solubilities of ammonium iodide, ammonium bromide, and ammonium iodide-ammonium bromide mixture in liquid ammonia

Journal of Chemical & Engineering Data, 1986
CHEMA Chemistry Data Series: Frankfurt, 1977; Vol. I. (5) McKeigue, K. Ph.D. Thesis, The University of Michigan, 1985. (6) Schuster, P.; Zundel, 0.; Sandorfy, C. The Hydfcgen Bond; North-Hoiland: Amsterdem, 1976. (7) Chaw, E.; Cataldo, J. C. G.: Streett. W. 6. J . Chem. fng. Date 1982, 27, 293. (8) McKelgue, K.; Gularl, E. J . Phys. Chem.
Hideki Yamamoto, Junji Tokunaga, Seiji Sanga   +2 more
openaire   +1 more source

An ammonium/bis-ammonium switchable molecular shuttle

Tetrahedron, 2008
A pH shuttle has been developed in which the mean position of the macrocycle can be switched between dialkylammonium stations of differing acidities. With only the most basic binding site protonated (dibenzylammonium), the macrocycle resides almost exclusively on the protonated station; when the second ammonium group (diethylammonium) is generated by ...
Leigh, David A.; id_orcid 0000-0002-1202-4507, Thomson, Andrew R.   +1 more
openaire   +1 more source

Density and viscosity of ammonium nitrate, ammonium nitrate–potassium chloride and ammonium nitrate—ammonium phosphate melts

Journal of Applied Chemistry, 1967
AbstractThe results of density and viscosity measurements are given for ammonium nitrate and the salt mixtures ammonium nitrate—potassium chloride and ammonium nitrate‐ammonium dihydrogen phosphate. The latter system is complicated because of the formation of non‐ortho phosphates and the results obtained refer to the equilibrium mixture obtained after ...
D. H. Booth, V. C. Vinyard
openaire   +1 more source