Results 61 to 70 of about 449,412 (331)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Influence of Nitrogen Fertilizer on the Antioxidative Potential of Basil Varieties (Ocimum basilicum L.)

Molecules, 2022
Total phenolic content (TPC) in extracts of basil depended on the cultivar and type of fertilization used in cultivation. TPC was determined spectrophotometrically with the Folin–Ciocalteu reagent.
Marzanna Hęś, Anna Golcz, Anna Gramza-Michałowska, Anna Jędrusek-Golińska, Krzysztof Dziedzic, Sylwia Mildner-Szkudlarz   +5 more
doaj   +1 more source

Nitrogen isotope analysis of ammonium and glycine [PDF]

, 2005
Stable isotope techniques can be used as a tool in nitrogen cycling studies of different ecosystems. The studies are based on measurement of the heavy (15N)- to- light (14N) isotopic ratios of nitrogen in different biospheric pools.
Norlin, Elin
core  

Model mass spectrometric study of competitive interactions of antimicrobial bisquaternary ammonium drugs and aspirin with membrane phospholipids [PDF]

, 2013
The aim of the study is to reveal molecular mechanisms of possible activity modulation of antimicrobial bis-quaternary ammonium compounds (BQAC) and aspirin (ASP) through noncovalent competitive complexation under their combined introduction into the ...
Gömöry, Ágnes, Kosevich, M. V., Pashynska, V. A., Vékey, Károly   +3 more
core   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Identification of PLK1-PBD Inhibitors from the Library of Marine Natural Products: 3D QSAR Pharmacophore, ADMET, Scaffold Hopping, Molecular Docking, and Molecular Dynamics Study

Marine Drugs
PLK1 is found to be highly expressed in various types of cancers, but the development of inhibitors for it has been slow. Most inhibitors are still in clinical stages, and many lack the necessary selectivity and anti-tumor effects.
Nan Zhou, Chuangze Zheng, Huiting Tan, Lianxiang Luo   +3 more
doaj   +1 more source

Organic or mineral fertilization [PDF]

, 2005
To meet Swedish environmental goals organic farming will play an important role in the development of a sustainable and high quality food production system.
Heeb, Anuschka
core  

An overview of atmospheric deposition chemistry over the Alps: present status and long-term trends [PDF]

, 2006
Several research programs monitoring atmospheric deposition have been launched in the Alpine countries in the last few decades. This paper uses data from previous and ongoing projects to: (i) investigate geographical variability in wet deposition ...
Arisci, Sylvia, Balestrini, Raflaella, Barbieri, Alberto, Brizzio, Maria Cristina, Kalina, Michael, Mosello, Rosario, Nickus, Ulrike, Probst, Anne, Puxbaum, Hans, Rogora, Michela, Schmitt, Marcel, Stähli, Manfred, Thimonier, Anne, Ulrich, Erwin, Waldner, Peter   +14 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Application of Quaternary Ammonium Compounds as Compatibilizers for Polymer Blends and Polymer Composites—A Concise Review

Applied Sciences, 2021
A wide variety of quaternary ammonium compounds (QACs) have escalated the attraction of researchers to explore the application of QACs. The compounds have frequently been synthesized through alkylation or quaternization of tertiary amines with alkyl ...
Ahmad Adlie Shamsuri, Siti Nurul Ain Md. Jamil   +1 more
doaj   +1 more source