Results 31 to 40 of about 2,396 (188)

Prescription drug monitoring programs use mandates and prescription stimulant and depressant quantities

BMC Public Health, 2023
Background While the mandate to check patients’ prescription history in Prescription Drug Monitoring Program (PDMP) database before prescribing/dispensing controlled drugs has been shown to be an important tool to curb opioid abuse, less is known about ...
Christian Gunadi, Yuyan Shi
doaj   +1 more source

Metabolic and pharmacological profiling of Penicillium claviforme by a combination of experimental and bioinformatic approaches

Annals of Medicine, 2022
Background Penicillium produces a wide range of structurally diverse metabolites with significant pharmacological impacts in medicine and agriculture. For the first time, a complete metabolome of Penicillium claviforme (P.
Zafar Ali Shah, Khalid Khan, Zafar Iqbal, Tariq Masood, Hassan A. Hemeg, Abdur Rauf   +5 more
doaj   +1 more source

Presurgical Functional Cortical Mapping Using Electromagnetic Source Imaging

Frontiers in Neurology, 2019
Preoperative localization of functionally eloquent cortex (functional cortical mapping) is common clinical practice in order to avoid or reduce postoperative morbidity.
Rudolf Kreidenhuber, Rudolf Kreidenhuber, Xavier De Tiège, Xavier De Tiège, Stefan Rampp, Stefan Rampp   +5 more
doaj   +1 more source

Epilepsy surgery without invasive EEG: early results of a new program Cirurgia de epilepsia sem EEG invasivo: resultados preliminares de um novo programa

Arquivos de Neuro-Psiquiatria, 1997
A total of 42 patients were submitted to a clinical, behavioural and neuropsychological evaluation with the objective of eventual surgical treatment of epilepsy refractory to the usual clinical therapies.
Paulo R. M. de Bittencourt, João C. Araújo, Paulo J. M. Leite, Marlus S. Moro, Edson R. Piana, Marcos C. Sandmann   +5 more
doaj   +1 more source

A simple magnetoencephalographic auditory paradigm may aid in confirming left-hemispheric language dominance in epilepsy patients. [PDF]

PLoS ONE, 2018
OBJECTIVE:The intracarotid amobarbital procedure (IAP) is the current "gold standard" in the preoperative assessment of language lateralization in epilepsy surgery candidates. It is, however, invasive and has several limitations.
Juha Wilenius, Henri Lehtinen, Ritva Paetau, Riitta Salmelin, Erika Kirveskari   +4 more
doaj   +1 more source

Comparison of Effects of Metformin, Phenformin, and Inhibitors of Mitochondrial Complex I on Mitochondrial Permeability Transition and Ischemic Brain Injury

Biomolecules, 2020
Damage to cerebral mitochondria, particularly opening of mitochondrial permeability transition pore (MPTP), is a key mechanism of ischemic brain injury, therefore, modulation of MPTP may be a potential target for a neuroprotective strategy in ischemic ...
Kristina Skemiene, Evelina Rekuviene, Aiste Jekabsone, Paulius Cizas, Ramune Morkuniene, Vilmante Borutaite   +5 more
doaj   +1 more source

N-Glucosidation of amobarbital in the cat

, 1985
N-Glucosidation is a novel pathway of barbiturate metabolism, so far known to occur only in man. A search for an animal model, conducted through in vitro screening, revealed that amobarbital-N-glucoside was formed in liver preparations from the cat. The
Bing K. Tang, Mallé Jurima, Werner Kalow, Giovanna Carro-Ciampi, Dezso Kadar   +4 more
core   +1 more source

Optimizing Magnetoencephalographic Imaging Estimation of Language Lateralization for Simpler Language Tasks

Frontiers in Human Neuroscience, 2020
Magnetoencephalographic imaging (MEGI) offers a non-invasive alternative for defining preoperative language lateralization in neurosurgery patients. MEGI indeed can be used for accurate estimation of language lateralization with a complex language task –
Leighton B. N. Hinkley, Elke De Witte, Elke De Witte, Megan Cahill-Thompson, Danielle Mizuiri, Coleman Garrett, Susanne Honma, Anne Findlay, Maria Luisa Gorno-Tempini, Maria Luisa Gorno-Tempini, Phiroz Tarapore, Heidi E. Kirsch, Peter Mariën, John F. Houde, Mitchel Berger, Srikantan S. Nagarajan   +15 more
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Species differences of amobarbital metabolism: dihydroxyamobarbital formation

, 1980
Amobarbital is almost completely metabolized in animals and man. The major metabolite is 3′-hydroxyamobarbital. The second major metabolite in dog, mice, hamsters, guinea pigs, and rats could be identified as 3′,4′-dihydroxyamobarbital.
B. K. Tang, W. Kalow, A. A. Grey, P. A. J. Reilly   +3 more
core   +1 more source

Determination of barbiturates in hair samples by using a validated UHPLC-HRMS method: application in investigation of drug-facilitated sexual assault

Forensic Sciences Research, 2019
In recent years, benzodiazepines and benzodiazepine-like drugs are the most common substances associated with drug-facilitated sexual assaults (DFSA); however, barbiturates are also detected occasionally.
Di Wen, Yan Shi, Xiaoguang Zhang, Bing Xie, Wenqiao Liu, Feng Yu, Ping Xiang, Bin Cong, Chunling Ma   +8 more
doaj   +1 more source