Results 31 to 40 of about 2,256 (188)

Comparison of Effects of Metformin, Phenformin, and Inhibitors of Mitochondrial Complex I on Mitochondrial Permeability Transition and Ischemic Brain Injury

Biomolecules, 2020
Damage to cerebral mitochondria, particularly opening of mitochondrial permeability transition pore (MPTP), is a key mechanism of ischemic brain injury, therefore, modulation of MPTP may be a potential target for a neuroprotective strategy in ischemic ...
Kristina Skemiene, Evelina Rekuviene, Aiste Jekabsone, Paulius Cizas, Ramune Morkuniene, Vilmante Borutaite   +5 more
doaj   +1 more source

N-Glucosidation of amobarbital in the cat

, 1985
N-Glucosidation is a novel pathway of barbiturate metabolism, so far known to occur only in man. A search for an animal model, conducted through in vitro screening, revealed that amobarbital-N-glucoside was formed in liver preparations from the cat. The
Bing K. Tang, Mallé Jurima, Werner Kalow, Giovanna Carro-Ciampi, Dezso Kadar   +4 more
core   +1 more source

Optimizing Magnetoencephalographic Imaging Estimation of Language Lateralization for Simpler Language Tasks

Frontiers in Human Neuroscience, 2020
Magnetoencephalographic imaging (MEGI) offers a non-invasive alternative for defining preoperative language lateralization in neurosurgery patients. MEGI indeed can be used for accurate estimation of language lateralization with a complex language task –
Leighton B. N. Hinkley, Elke De Witte, Elke De Witte, Megan Cahill-Thompson, Danielle Mizuiri, Coleman Garrett, Susanne Honma, Anne Findlay, Maria Luisa Gorno-Tempini, Maria Luisa Gorno-Tempini, Phiroz Tarapore, Heidi E. Kirsch, Peter Mariën, John F. Houde, Mitchel Berger, Srikantan S. Nagarajan   +15 more
doaj   +1 more source

Species differences of amobarbital metabolism: dihydroxyamobarbital formation

, 1980
Amobarbital is almost completely metabolized in animals and man. The major metabolite is 3′-hydroxyamobarbital. The second major metabolite in dog, mice, hamsters, guinea pigs, and rats could be identified as 3′,4′-dihydroxyamobarbital.
B. K. Tang, W. Kalow, A. A. Grey, P. A. J. Reilly   +3 more
core   +1 more source

Determination of barbiturates in hair samples by using a validated UHPLC-HRMS method: application in investigation of drug-facilitated sexual assault

Forensic Sciences Research, 2019
In recent years, benzodiazepines and benzodiazepine-like drugs are the most common substances associated with drug-facilitated sexual assaults (DFSA); however, barbiturates are also detected occasionally.
Di Wen, Yan Shi, Xiaoguang Zhang, Bing Xie, Wenqiao Liu, Feng Yu, Ping Xiang, Bin Cong, Chunling Ma   +8 more
doaj   +1 more source

Joint Effect of Amobarbital and Response Prevention on Car Extinction

, 1968
The purpose of this study was to extend previous findings of enhanced CAR extinction with response prevention by demonstrating that extinction may be further facilitated by amobarbital treatment during response prevention.
Dennis K. Kamano
core   +1 more source

Simultaneous Determination of Phenobarbital, Pentobarbital, Amobarbital and Secobarbital in Raw Milk via Liquid Chromatography with Electron Spray Ionization Tandem Mass Spectrometry

Food Science of Animal Resources, 2017
A rapid, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of four barbiturates (phenobarbital, pentobarbital, amobarbital and secobarbital) in raw milk.
Huaixiang Tian, Xingxin Zhou, Chen Chen, Yabin He, Haiyan Yu, Xiaoping Zheng   +5 more
doaj   +1 more source

Characteristics and long‐term outcomes of children with confirmed focal cortical dysplasia type 1 after epilepsy surgery: A population‐based study

Epilepsia Open, EarlyView.
Abstract Objective Focal cortical dysplasia type 1 (FCD1) is a rare and heterogeneous cause of drug‐resistant epilepsy (DRE) in children. Its clinical characteristics remain poorly understood, and surgical outcomes may be less favorable than in FCD2. We conducted a population‐based study to characterize the clinical presentation and long‐term seizure ...
Vincent Zheng, Päivi Koroknay‐Pál, Henri Lehtinen, Eija Gaily, Atte Karppinen, Anders Paetau, Olli Tynninen, Heta Leinonen, Aki Laakso, Eeva‐Liisa Metsähonkala   +9 more
wiley   +1 more source

Drug Critical Limits for Urgent Physician Notification

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 178-192, July 2026.
Critical limits represent quantitative decision thresholds for drugs that require immediate clinician notification and potential life‐saving intervention. United States hospitals lack a national standard for drug critical limits. We collected critical limits from 417 US hospitals across all 50 states and Washington, D.C.; of these, 411 maintained drug ...
Elina Kuang, Yasmeen Ibrahim, Kyle Cheng, Gerald J. Kost   +3 more
wiley   +1 more source

Blockade of Electron Transport at the Onset of Reperfusion Decreases Cardiac Injury in Aged Hearts by Protecting the Inner Mitochondrial Membrane

Journal of Aging Research, 2012
Myocardial injury is increased in the aged heart following ischemia-reperfusion (ISC-REP) compared to adult hearts. Intervention at REP with ischemic postconditioning decreases injury in the adult heart by attenuating mitochondrial driven cell injury ...
Qun Chen, Thomas Ross, Ying Hu, Edward J. Lesnefsky   +3 more
doaj   +1 more source