Results 121 to 130 of about 15,045 (253)

Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo

Memorias do Instituto Oswaldo Cruz, 2007
Resistance in Plasmodium falciparum to amodiaquine (AQ) can be reversed in vitro with with antihistaminic and tricyclic antidepressant compounds, but its significance in vivo is unclear.
Akintunde Sowunmi, Grace O Gbotosho, Christian T Happi, Ahmed A Adedeji, Olayinka M Bolaji, Fatai A Fehintola, Babasola A Fateye, Ayoade MJ Oduola   +7 more
doaj  

In silico comparative genomics analysis of Plasmodium falciparum for the identification of putative essential genes and therapeutic candidates.

, 2014
A sequence of computational methods was used for predicting novel drug targets against drug resistant malaria parasite Plasmodium falciparum. Comparative genomics, orthologous protein analysis among same and other malaria parasites and protein-protein ...
Altschul, Andrews, Anishetty, Arama, Berman, Bernstein, Bhasin, Boeckmann, Chang, Chawley, Chen, Colovos, Corpet, David Charles Warhurst, Eisenberg, Finn, Franceschini, Ghosh, Irwin, Irwin, Kanehisa, Konc, Krogh, Kushwaha, Larsen, Laskowski, Ludin, Miller, Morris, Mrutyunjay Suar, Mulder, Pieper, Pierleoni, Pontius, Rajani Kanta Mahapatra, Sali, Subhashree Rout, Sun, Tam, von Mering, Wallner, Wiederstein, World Health Organization, Yang, Yeh, Zhexin   +45 more
core   +1 more source

Interactions of the antimalarial amodiaquine with lipid model membranes

Chemistry and Physics of Lipids, 2015
A detailed molecular description of the mechanism of action of the antimalarial drug amodiaquine (AQ) is still an open issue. To gain further insights on that, we studied the interactions of AQ with lipid model membranes composed of dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylserine (DPPS) by spin labeling electron spin resonance ...
Luis G.M. Basso, Rafael P. Barroso, Antonio J. Costa-Filho   +2 more
openaire   +3 more sources

Prevalence of CYP2C8*2 and *3 among Eritreans and its Potential Impact on Artesunate/Amodiaquine Treatment

Pharmacogenomics and Personalized Medicine, 2020
Lidia Habtemikael,1 Mulugeta Russom,2 Iyassu Bahta,2 Selam Mihreteab,3 Araia Berhane,4 Andreas Mårtensson,1 Jose Pedro Gil1,5,6 1Department of Women’s and Children’s Health, International Maternal and Child Health (IMCH), Uppsala ...
Habtemikael L, Russom M, Bahta I, Mihreteab S, Berhane A, Mårtensson A, Gil JP   +6 more
doaj  

Cardiac effects of amodiaquine and sulfadoxine-pyrimethamine in malaria-infected African patients. [PDF]

, 2001
B Ngouesse, Léonardo K. Basco, Pascal Ringwald, A Keundjian, Kathleen Ngu Blackett   +4 more
openalex   +1 more source

Acute asymptomatic hepatitis in a healthy normal volunteer exposed to 2 oral doses of amodiaquine and artesunate [PDF]

, 2001
Catherine Orrell, Walter R. J. Taylor, P. Offiaro   +2 more
openalex   +1 more source

Examination of effectiveness of chemical scavengers as therapeutics in organophosphate poisoning [PDF]

, 2017
Cholinergic crisis triggered by inhibition of cholinesterases via organophosphorus nerve agents (OP) and pesticides is treated with atropine and a reactivator of inhibited cholinesterase, called oxime.
Bierwisch, Anne
core  

Combination of Drug Level Measurement and Parasite Genotyping Data for Improved Assessment of Amodiaquine and Sulfadoxine-Pyrimethamine Efficacies in Treating Plasmodium falciparum Malaria in Gabonese Children [PDF]

, 2002
Agnès Aubouy, Mohamed Bakary, A Keundjian, Bernard Mbomat, Jean Ruffin Makita, Florence Migot‐Nabias, Michel Cot, Jacques Le Bras, Philippe Deloron   +8 more
openalex   +1 more source

Amodiaquine ameliorates stress-induced premature cellular senescence via promoting SIRT1-mediated HR repair

Cell Death Discovery
DNA damage is considered to be a potentially unifying driver of ageing, and the stalling of DNA damage repair accelerates the cellular senescence. However, augmenting DNA repair has remained a great challenge due to the intricate repair mechanisms ...
Jie Du, Fuqiang Chen, Chenghong Du, Wenna Zhao, Zihan Chen, Zhenhua Ding, Meijuan Zhou   +6 more
doaj   +1 more source

Use of weight-for-age-data to optimize tablet strength and dosing regimens for a new fixed-dose artesunate-amodiaquine combination for treating falciparum malaria

Bulletin of the World Health Organization
OBJECTIVE: To test a novel methodology to define age-based dosing regimens for the treatment of malaria with a new, user-friendly, blister-packaged fixed-dose combination of artesunate and amodiaquine.
Walter RJ Taylor, Dianne J Terlouw, Piero L Olliaro, Nicholas J White, Philippe Brasseur, Feiko O ter Kuile   +5 more
doaj   +1 more source