Results 1 to 10 of about 22,882 (212)

Traitement préventif intermittent à la sulfadoxine à pyriméthamine du paludisme chez les femmes enceintes: efficacité et observance dans deux hôpitaux urbains du Burkina Faso

The Pan African Medical Journal, 2013
INTRODUCTION: La présente étude prospective se propose d'évaluer l'efficacité thérapeutique du traitement préventif intermittent à la sulfadoxine pyriméthamine et son observance chez la femme enceinte dans deux hôpitaux urbains au Burkina Faso. METHODES:
Sanata Bamba, Adama Séré, Rodrigues Nikiéma, Tinto Halidou, Blandine Thieba, Blami Dao, Robert Tinga Guiguemdé   +6 more
doaj   +1 more source

The characteristic structural and functional dynamics of P. falciparum DHFR binding with pyrimidine chemotypes implicate malaria therapy design

Chemical Physics Impact
Dihydrofolate reductase (DHFR) enzyme regulates de-novo folate synthesis in Plasmodium falciparum, hence a critical malaria drug target. Pyrimethamine inhibits DHFR, but resistance and lack of cross-species activity are key challenges.
Wande M. Oluyemi, Goodness Nwokebu, Adeniyi T. Adewumi, Shadrach C. Eze, Chinedu C. Mbachu, Emmanuel C. Ogueli, Ngozi Nwodo, Mahmoud E.S. Soliman, Salerwe Mosebi   +8 more
doaj   +1 more source

Dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy: a systematic review and individual participant data meta-analysisResearch in context

EClinicalMedicine
Summary: Background: High-grade Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in east and southern Africa has prompted trials evaluating intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin-piperaquine as an ...
Michelle E. Roh, Julie R. Gutman, Maxwell Murphy, Jenny Hill, Mywayiwawo Madanitsa, Abel Kakuru, Hellen C. Barsosio, Simon Kariuki, John P.A. Lusingu, Frank Mosha, Richard Kajubi, Moses R. Kamya, Don Mathanga, Jobiba Chinkhumba, Miriam K. Laufer, Eulambius Mlugu, Appolinary A.R. Kamuhabwa, Eleni Aklillu, Omary Minzi, Roland Nnaemeka Okoro, Ado Danazumi Geidam, John David Ohieku, Meghna Desai, Prasanna Jagannathan, Grant Dorsey, Feiko O. ter Kuile   +25 more
doaj   +1 more source

Study of anti-Toxoplasma gondii effect of mPEG–PCL copolymeric loaded with pyrimethamine, in vitro

AMB Express
The discovery of new drugs with minimal toxicity is crucially important in the search for effective treatments for toxoplasmosis. The study aimed to assess the effectiveness of pyrimethamine-loaded mPEG–PCL copolymeric nanoparticles (mPEG–PCL–Pyr ...
Mobina Gholami, Hossein Danafer, Mitra Sadeghi, Ahmad Daryani, Seyed Abdollah Hosseini, Shirzad Gholami   +5 more
doaj   +1 more source

RESPONSE OF FALCIPARUM MALARIA TO A COMBINATION OF QUININE AND SULFADOXINE-PYRIMETHAMINE IN BOOMY COUNTY OF LIBERIA

Pakistan Armed Forces Medical Journal, 2010
Objective: To document the response of Falciparum malaria to a combination of Quinine and sulfadoxine- Pyrimethamine in Boomy County of Liberia. Study Design: Quasi-experimental study. Place and duration of Study: Pak Level-II Hospital Tubmanburg, Boomy
Lt Col Muhammad Tariq, Asad Mehmood, Saleemullah .   +2 more
doaj   +2 more sources

Efficacy and safety of single-dose artesunate plus sulfalene/pyrimethamine combined with praziquantel for the treatment of children with Schistosoma mansoni or Schistosoma haematobium in western Kenya: a randomised, open-label controlled trial

Parasites & Vectors
Background Reliance on praziquantel for the treatment and control of schistosomiasis is likely to facilitate the emergence of drug resistance. Combination therapy targeting adult and juvenile schistosome worms is urgently needed to improve praziquantel ...
Charles O. Obonyo, Fredrick O. Rawago, Nicholas K. Makworo, Erick M. O. Muok   +3 more
doaj   +1 more source

Effect of Immunomodulator Pyrimethamine and Cimetidine on Immunosuppression Induced by Burn Blister Fluid

Iranian Journal of Allergy, Asthma and Immunology, 2004
Despite recent advances in burn wound management, sepsis remains the main cause of death in patients resuscitated after major thermal injury. Increased susceptibility to infections has been related to severe suppression of the immune system.
Behnaz Gharegozloo, Zuhair M. Hassan, Sussan K. Ardestani, Nasser Tavassoli   +3 more
doaj  

Therapeutic efficacy of sulfadoxine-pyrimethamine, amodiaquine and the sulfadoxine-pyrimethamine-amodiaquine combination against uncomplicated Plasmodium falciparum malaria in young children in Cameroon

Bulletin of the World Health Organization, 2002
OBJECTIVE: To evaluate the therapeutic efficacy of sulfadoxine-pyrimethamine, amodiaquine, and the sulfadoxine-pyrimethamine-amodiaquine combination for the treatment of uncomplicated Plasmodium falciparum malaria in young children in Cameroon.
Basco Leonardo K., Same-Ekobo Albert, Ngane Vincent Foumane, Ndounga Mathieu, Metoh Theresia, Ringwald Pascal, Soula Georges   +6 more
doaj  

Deconstructing empirical fitness seascapes across scales of granularity. [PDF]

G3 (Bethesda)
Manivannan SN, Ogbunugafor CB.
europepmc   +1 more source

Expiration Date of Extemporaneous Pyrimethamine Formulations for Treating Congenital Toxoplasmosis: Physicochemical and Microbiological Evaluation. [PDF]

ACS Omega
de Paula RM, Santana VBS, Amorim MVP, Dourado D, Alencar ÉDN, de Aquino DAO, Veríssimo LM.   +6 more
europepmc   +1 more source