Results 31 to 40 of about 22,882 (212)

Evaluation of Dihydrofolate Reductase (Dhfr) Gene, Related to Plasmodium Falciparum Pyrimethamine Resistance in Imported Malaria Cases in Iran

Research in Molecular Medicine, 2021
Background: Antimalarial drug resistance is one of the important challenges for governments in the fight against malaria. Molecular surveillance of antimalarial drug resistance supports early detection of how the recommended treatments work.
Seyyed Ali Shariatzadeh, Reza Valadan, Seyed Abdollah Hosseini, Adel Spotin, Abbas Shahbazi, Davood Anvari, Fattaneh Montazeri, Javad Javidnia, Shirzad Gholami   +8 more
doaj  

Audit of failure rate of sulfadoxine/pyrimetham combined with chloroquine to treat falciparum malaria at single fourteen-day follow-up

South African Family Practice, 2002
Objective: To assess the failure rate of the present first line treatment regime for uncomplicated falciparum malaria of sulfadoxine/pyrimethamine combined with chloroquine. Design: A before-after study. Setting: Ndumo Clinic, Ingwavuma District, South
C.H. Vaughan Williams, C. La Cock, G.F.J. Henry, A.J. Ross   +3 more
doaj   +1 more source

Pyrimethamine Elicits Antitumor Effects on Prostate Cancer by Inhibiting the p38-NF-κB Pathway

Frontiers in Pharmacology, 2020
Since incurable castration-resistant prostate cancer (CRPC) inevitably develops following treatment with androgen deprivation therapy, there is an urgent need to devise new therapeutic strategies to treat this cancer.
Xumin Zhou, Xumin Zhou, Jinming Zhang, Xiaoping Hu, Peiqing He, Jianyu Guo, Jun Li, Tian Lan, Jumei Liu, Lilan Peng, Hua Li   +10 more
doaj   +1 more source

Effects of pyrimethamine-sulphadoxine, chloroquine plus chlorpheniramine, and amodiaquine plus pyrimethamine-sulphadoxine on gametocytes during and after treatment of acute, uncomplicated malaria in children

Memorias do Instituto Oswaldo Cruz, 2006
The effects of pyrimethamine-sulphadoxine (PS), chloroquine plus chlorpheniramine, a H1 receptor antagonist that reverses chloroquine resistance in Plasmodium falciparum in vitro and in vivo (CQCP), and amodiaquine plus pyrimethamine-sulphadoxine (AQPS ...
A Sowunmi, AA Adedeji, GO Gbotosho, BA Fateye, TC Happi   +4 more
doaj   +1 more source

High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children. [PDF]

, 2011
BACKGROUND: Drug resistance contributes to the global malaria burden. Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) polymorphisms confer resistance to sulphadoxine-pyrimethamine (SP). METHODS: The study assessed
Gabor, Julian J., Profanter, K., Grobusch, Martin P., Kurth, F., Grobusch, Martin P, Gabor, J.J., Gabor Julian J, Oyakhirome, Sunny, Oyakhirome, S., Kun, Jürgen FJ, Greutélaers, Benedikt, Jürgen FJ Kun, Grobusch Martin P, Kremsner, P.G., Issifou, Saadou, Kun, Jürgen F. J., Grobusch, M.P., Saadou Issifou, Issifou, S., Roper, C., Ord, Rosalynn, Roper, Cally, Mombo-Ngoma, Ghyslain, Peter G Kremsner, Greutélaers, K.C., Kremsner, Peter G., Katharina Profanter, Martin P Grobusch, Sunny Oyakhirome, Lell, Bertrand, Greutélaers, B., Greutélaers, Katja C., Greutélaers, Katja C, Kurth, Florian, Julian J Gabor, Rosalynn Ord, Mombo-Ngoma, G., Cally Roper, Florian Kurth, Issifou Saadou, Mombo-Ngoma Ghyslain, Ord Rosalynn, Gabor, Julian J, Oyakhirome Sunny, Kremsner, Peter G, Kun Jürgen FJ, Katja C Greutélaers, Ghyslain Mombo-Ngoma, Kurth Florian, Greutélaers Benedikt, Roper Cally, Profanter Katharina, Kun, J.F.J., Kremsner Peter G, Bertrand Lell, Lell Bertrand, Benedikt Greutélaers, Lell, B., Ord, R., Greutélaers Katja C, Profanter, Katharina   +60 more
core   +2 more sources

Randomised trial of chloroquine/sulphadoxine-pyrimethamine in Gambian children with malaria: impact against multidrug-resistant P. falciparum. [PDF]

, 2006
OBJECTIVES: In the Gambia, the combination of chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) has replaced CQ monotherapy for treatment of malaria caused by Plasmodium falciparum. We measured the efficacy of the combination CQ/SP, and the prevalence
Targett Geoffrey A. T, Sutherland Colin J, Samuel Dunyo, Jawara, Musa, Coleman, Rosalind, Alexander Neal, Mesa, Eduardo, Sutherland, Colin J, Hallett, Rachel, Rachel Hallett, Ord Rosalynn, Coleman Rosalind, Musa Jawara, Geoffrey A. T Targett, Pinder Margaret, Jawara Musa, Ord, Rosalynn, Walraven, Gijs, Sowe, Maimuna, Targett, Geoffrey AT, Eduardo Mesa, Dunyo, Samuel, Neal Alexander, Colin J Sutherland, Rosalind Coleman, Gijs Walraven, Sowe Maimuna, Walraven Gijs, Mesa Eduardo, Alexander, Neal, Margaret Pinder, Dunyo Samuel, Rosalynn Ord, Maimuna Sowe, Pinder, Margaret, Hallett Rachel   +35 more
core   +1 more source

The efficacy of antimalarial monotherapies, sulphadoxine-pyrimethamine and amodiaquine in East Africa: implications for sub-regional policy. [PDF]

, 2003
Between 1998 and 2001, Kenya, Uganda, Tanzania, Zanzibar, Rwanda and Burundi changed antimalarial drug policy, in the face of widespread chloroquine resistance.
East African Network for Monitoring Antimalarial Treatment (EANMAT), East African Network for Monitoring Antimalarial Treatment (EANM   +1 more
core   +1 more source

IN VIVO ASSESSMENT OF THE EFFECTS OF METHOTREXATE ON LATENT TOXOPLASMOSIS [PDF]

Journal of the Egyptian Society of Parasitology, 2017
Toxoplasma gondii (T. gondii) has been shown to result in life-threatening encephalitis in immunocompromised patients after reactivation of dormant parasites.
EMAN SAAD, EMAN ABDEL BARY, MOHAMED SARHAN, MAHMOUD EL-SHAFEY, MAI ABD EL-AZEEM, DALIA ABO EL-MAATY, SAMIA ETEWA   +6 more
doaj   +1 more source

Protective efficacy of intermittent preventive treatment of malaria in infants (IPTi) using sulfadoxine-pyrimethamine and parasite resistance. [PDF]

, 2010
BACKGROUND: Intermittent Preventive Treatment of malaria in infants using sulfadoxine-pyrimethamine (SP-IPTi) is recommended by WHO for implementation in settings where resistance to SP is not high. Here we examine the relationship between the protective
Grobusch, Martin P., Gosling, Roly D., Ghani, Azra C, Daniel Chandramohan, Cairns, M., Matthew Cairns, Newman, R.D., Grobusch, Martin P, Schellenberg David, Newman, Robert D, Azra C Ghani, Gosling, R.D., Greenwood, Brian, Cairns, Matthew, Chandramohan Daniel, Jamie T. Griffin, Grobusch, M.P., Robert D Newman, Newman, Robert D., Roper, C., Schellenberg, D., Roper, Cally, Ghani, Azra C., Griffin, Jamie T, Greenwood Brian, Martin P Grobusch, Carneiro, Ilona, Jamie T Griffin, Chandramohan, Daniel, Ghani Azra C., Greenwood, B., Roly D Gosling, Schellenberg, David, Griffin, Jamie T., Cairns Matthew, Cally Roper, Gosling, Roly D, Gosling Roly D., Newman Robert D., Ghani, A.C., Martin P. Grobusch, Carneiro, I., Griffin Jamie T., Azra C. Ghani, Brian Greenwood, Daniel Ch, Griffin, J.T., Roper Cally, Roly D. Gosling, David Schellenberg, Grobusch Martin P., Roly D, Carneiro Ilona, Robert D. Newman, Chandramohan, D., Ilona Carneiro   +55 more
core   +3 more sources

Mutaciones puntuales en los genes dhfr y dhps de Plasmodium falciparum de tres regiones endémicas

Biomédica: revista del Instituto Nacional de Salud, 2010
Introducción. La acumulación progresiva de mutaciones en los genes dhfr y dhps lleva al parásito Plasmodium falciparum a evadir la acción de la sulfadoxina-pirimetamina, situación que aumenta el nivel de resistencia del parásito a estos medicamentos y ...
John Alexander Galindo, Fabio Aníbal Cristiano, Angélica Knudson, Rubén Santiago Nicholls, Ángela Patricia Guerra   +4 more
doaj   +1 more source