Results 51 to 60 of about 16,294 (175)
American Journal of Hematology, Volume 101, Issue S1, Page 5-16, April 2026.What are the available data on incidence & prevalence prognosis risk factors of severity of sickle cell disease in sub‐Saharan Africa? ABSTRACT Sickle Cell Disease (SCD) is highly prevalent in sub‐Saharan Africa. Epidemiological data remain sparse, but regional screening and research initiatives are expanding.
Brigitte Ranque +2 more
wiley +1 more source
Brain and Behavior, Volume 16, Issue 4, April 2026.Parasitic infections like schistosomiasis, soil‐transmitted helminths, and malaria can impair nutrient absorption, oxygen supply, and brain function, leading to memory deficits, attention deficits, reduced intelligence quotient, weak academic performance, and motor or executive deficits.
Albertha Maku Adu +7 more
wiley +1 more source
Drug Development Research, Volume 87, Issue 2, April 2026.ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Elodie Chenu +7 more
wiley +1 more source
Frontiers in PediatricsThis work reports a case of neonatal congenital toxoplasmosis in which the standard regimen of pyrimethamine combined with sulfadiazine was administered under conditions of limited drug accessibility in China, with multidisciplinary collaboration and ...
Ya Hu +9 more
doaj +1 more source
Health Science Reports, Volume 9, Issue 4, April 2026.ABSTRACT Background Malaria remains a major public health challenge in sub‐Saharan Africa, with the Democratic Republic of the Congo (DR Congo) contributing substantially to the global burden. DR Congo accounts for 12% of global malaria cases. This study aims to assess the intersectionality of epidemiological, immunological, and conflict‐related ...
Aymar Akilimali +13 more
wiley +1 more source
Journal of Mazandaran University of Medical Sciences, 2021 Background and purpose: There are few treatment options available for treatment of toxoplasmosis and effective drugs have serious toxic effects. In this study, the in vivo and in vitro anti-toxoplasma activities of Heracleum persicum and Foeniculum ...
Mahbobeh Montazeri +7 more
doaj
PLoS ONE, 2014 North-east India, being a corridor to South-east Asia, is believed to play an important role in transmitting drug resistant Plasmodium falciparum malaria to India and South Asia.
Pradyumna Kishore Mohapatra +8 more
doaj +1 more source
The Risk of Recrystallization: Changes to the Toxicity and Morphology of Pyrimethamine
Journal of Pharmacy & Pharmaceutical Sciences, 2014 PURPOSE. Pyrimethamine, an anti-malarial agent known to exhibit solid state polymorphism, may be purified by means of recrystallization. Recrystallization may alter the solid state chemistry of pharmaceuticals, which may impact the toxicity and/or ...
Zak Perold, Mino R Caira, Marius Brits
doaj +1 more source
The Pan African Medical Journal, 2013 INTRODUCTION: La présente étude prospective se propose d'évaluer l'efficacité thérapeutique du traitement préventif intermittent à la sulfadoxine pyriméthamine et son observance chez la femme enceinte dans deux hôpitaux urbains au Burkina Faso. METHODES:
Sanata Bamba +6 more
doaj +1 more source
Chemical Physics ImpactDihydrofolate reductase (DHFR) enzyme regulates de-novo folate synthesis in Plasmodium falciparum, hence a critical malaria drug target. Pyrimethamine inhibits DHFR, but resistance and lack of cross-species activity are key challenges.
Wande M. Oluyemi +8 more
doaj +1 more source