Therapeutic Efficacy of Sulfadoxine-Pyrimethamine and Prevalence of Resistance Markers in Tanzania Prior to Revision of Malaria Treatment Policy: Plasmodium Falciparum Dihydrofolate Reductase and Dihydropteroate Synthase Mutations in Monitoring in Vivo Resistance. [PDF]
Prior to the 2001 malarial treatment policy change in Tanzania, we conducted trials to assess the efficacy of sulfadoxine-pyrimethamine (SP) and the usefulness of molecular markers in monitoring resistance.
Abdulla, Salim +10 more
core +1 more source
Review of pyronaridine anti-malarial properties and product characteristics. [PDF]
Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has been used in China for over 30 years for the treatment of malaria.
Arbe-Barnes, Sarah J +7 more
core +2 more sources
Parasitic infections like schistosomiasis, soil‐transmitted helminths, and malaria can impair nutrient absorption, oxygen supply, and brain function, leading to memory deficits, attention deficits, reduced intelligence quotient, weak academic performance, and motor or executive deficits.
Albertha Maku Adu +7 more
wiley +1 more source
Adherence to the combination of sulphadoxine-pyrimethamine and artesunate in the Maheba refugee settlement, Zambia. [PDF]
Artemisinin-based combination therapy (ACT) is one strategy recommended to increase cure rates in malaria and to contain resistance to Plasmodium falciparum. In the Maheba refugee settlement, children aged 5 years or younger with a confirmed diagnosis of
Balkan, S +6 more
core +2 more sources
ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Elodie Chenu +7 more
wiley +1 more source
Responsiveness of emergency obstetric care systems in low- and middle-income countries: a critical review of the "third delay". [PDF]
We reviewed the evidence on the duration, causes and effects of delays in providing emergency obstetric care to women attending health facilities (the third delay) in low- and middle-income countries. We performed a critical literature review using terms
Cavallaro, Francesca L +1 more
core +1 more source
ABSTRACT Background Malaria remains a major public health challenge in sub‐Saharan Africa, with the Democratic Republic of the Congo (DR Congo) contributing substantially to the global burden. DR Congo accounts for 12% of global malaria cases. This study aims to assess the intersectionality of epidemiological, immunological, and conflict‐related ...
Aymar Akilimali +13 more
wiley +1 more source
Mode of action and choice of antimalarial drugs for intermittent preventive treatment in infants.
Intermittent preventive treatment in infants (IPTi) is an effective and safe malaria control strategy. However, it remains unclear what antimalarials should be used to replace sulfadoxine-pyrimethamine (SP) when and where SP is no longer an effective ...
Cairns, Matthew +5 more
core +1 more source
Cost-effectiveness of malaria diagnosis using rapid diagnostic tests compared to microscopy or clinical symptoms alone in Afghanistan [PDF]
Background Improving access to parasitological diagnosis of malaria is a central strategy for control and elimination of the disease. Malaria rapid diagnostic tests (RDTs) are relatively easy to perform and could be used in primary level clinics to ...
Anwar, Mohammed +10 more
core +3 more sources
ABSTRACT Background and Aim Malaria poses a major threat to pregnant women in Ghana, especially among marginalized nomadic Fulani communities. This study examined factors influencing insecticide‐treated net (ITN) ownership and use among Fulani pregnant women in northern Ghana. Methods A cross‐sectional survey was carried out between April and June 2022
Yula Salifu +5 more
wiley +1 more source

