Altered life history strategies protect malaria parasites against drugs
Evolutionary Applications, 2018 Drug resistance has been reported against all antimalarial drugs, and while parasites can evolve classical resistance mechanisms (e.g., efflux pumps), it is also possible that changes in life history traits could help parasites evade the effects of ...
Philip L. G. Birget +3 more
doaj +1 more source
Amitriptyline Induced Life‐Threatening Steven–Johnson Syndrome: Case Report
Clinical Case Reports, Volume 14, Issue 3, March 2026.ABSTRACT Stevens–Johnson syndrome is one of the few dermatological emergencies in clinical practice. The syndrome is often secondary to the usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine, and carbamazepine are commonly implicated.
Wondwosen Mengist Dereje +3 more
wiley +1 more source
Short Report: Association Between Chloroquine and Amodiaquine Resistance and Allelic Variation in the Plasmodium Falciparum Multiple Drug Resistance 1 Gene and the Chloroquine Resistance Transporter Gene in Isolates from the Upper Nile in Southern Sudan. [PDF]
, 2003 Amodiaquine, a 4-aminoquinoline compound, is being considered as an alternative to chloroquine and pyrimethamine/sulfadoxine where resistance in Plasmodium falciparum to both drugs has been selected.
Keus, K +3 more
core +1 more source
Pharmacoepidemiology and Drug Safety, Volume 35, Issue 3, March 2026.ABSTRACT Purpose Adverse drug reactions (ADRs) present significant obstacles for healthcare systems, impacting both patient safety and the effectiveness of treatments. Despite this, there is a scarcity of research on ADR reports in Sierra Leone, especially over long periods.
Isatu Jalloh +4 more
wiley +1 more source
Malaria Journal, 2007 Background Benin has recently shifted its national antimalarial drug policy from monotherapies to combinations containing artemisinin derivatives. When this decision was taken, the available information on alternatives to chloroquine and sulphadoxine ...
Coosemans Marc +10 more
doaj +1 more source
Invasive bacterial infections in Gambians with sickle cell anaemia in an era of widespread Pneumococcal and Haemophilus influenzae type B vaccination [PDF]
, 2016 Background: There is relatively little data on the aetiology of bacterial infections in patients with sickle cell anaemia (SCA) in West Africa, and no data from countries that have implemented conjugate vaccines against both Streptococcus pneumoniae and ...
Anderson, ST +5 more
core +1 more source
Acta Paediatrica, Volume 115, Issue 3, Page 634-642, March 2026.ABSTRACT Aim Growth faltering and loss of development potential are common in low‐ and middle‐income countries. We aimed to study whether linear growth before and after 2 years, height‐for‐age Z‐score (HAZ) from 1 month until 13 years and morbidity during the first 3 years predict adolescent cognitive ability.
Karoliina Videman +6 more
wiley +1 more source
Declining trend of Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant alleles after the withdrawal of Sulfadoxine-Pyrimethamine in North Western Ethiopia. [PDF]
PLoS ONE, 2015 Antimalarial drug resistance is one of the major challenges in global efforts of malaria control and elimination. In 1998, chloroquine was abandoned and replaced with sulfadoxine/pyrimethamine, which in turn was replaced with artemether/lumefantrine for ...
Sofonias K Tessema +7 more
doaj +1 more source
Frequency of Pfcrt T76 and Pfdhfr Asn-108 Drug Resistance Mutations in falciparum Malaria in Southeastern Malaria Endemic Area of Iran [PDF]
Iranian Journal of Public Health, 2008 Background: Point mutations in the genes, Pfcrt and Pfdhfr, have been identified elsewhere as strongly associated with resistance to chloroquine (CQ) and pyrimethamine, respectively.
MR Razavi +5 more
doaj +1 more source
Revista da Sociedade Brasileira de Medicina Tropical, 1967 Review of the early literature as well as more recent results show that sulfonamides possess a distinct antimalarial activity. However, when give alone, their action is less marked and slower than that of the antimalarials commonly used in the treatment ...
J. Herrero
doaj +1 more source