Results 61 to 70 of about 22,882 (212)

Randomised Clinical Trial to Evaluate the Efficacy of Acetazolamide for the Treatment of Cystoid Fluid Collections in X‐Linked Retinoschisis: The AXIS Trial

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background This trial aimed to evaluate the efficacy of oral acetazolamide in reducing cystoid fluid collections (CFC) and improving visual function in patients with X‐linked retinoschisis (XLRS). Methods In this investigator‐initiated, single centre, open‐label, randomised controlled trial, XLRS patients aged ≥ 12 years with fovea‐involving ...
Jonathan Hensman, Hind Almushattat, Roselie M. H. Diederen, Tien‐En Tan, Peilun Dai, Coen de Vente, Daniel S. W. Ting, Maria M. van Genderen, Jeannette Ossewaarde‐van Norel, Redmer van Leeuwen, Martha J. H. Tjon‐Fo‐Sang, Clara I. Sánchez, M. Dominik Fischer, Maximilian Pfau, Jos W. R. Twisk, Camiel J. F. Boon   +15 more
wiley   +1 more source

Intermittent preventive treatment for malaria in pregnancy in Africa: what's new, what's needed? [PDF]

, 2007
Falciparum malaria is an important cause of maternal, perinatal and neonatal morbidity in high transmission settings in Sub-Saharan Africa. Intermittent preventive treatment with sulphadoxine-pyrimethamine (SP-IPT) has proven efficacious in reducing the ...
Vallely, Andrew, Changalucha, John, Daniel Chandramohan, Greenwood Brian, John Changalucha, Vallely Andrew, Lisa Vallely, Vallely Lisa, Chandramohan, Daniel, Changalucha John, Greenwood, Brian, Brian Greenwood, Vallely, Lisa, Andrew Vallely, Chandramohan Daniel   +14 more
core   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Population-based validation of dihydrofolate reductase gene mutations for the prediction of sulfadoxine-pyrimethamine resistance in Uganda.

, 2003
Mutations in the dihydrofolate reductase gene (dhfr) of Plasmodium falciparum have been proposed as molecular markers for the surveillance of sulfadoxine-pyrimethamine (SP)-resistant malaria, but such proposals have not been validated. At 7 Ugandan sites
Watkins, W, Watkins, W., D'Alessandro, U., Langi, P., Egwang, T.G., Mutabingwa, T. K., Egwang, T. G., Mutabingwa, TK, Langi, P, Mutabingwa, T.K., Talisuna, A. O., D'Alessandro, U, Van Marck, E., d' Alessandro, U., Talisuna, A.O., Van Marck, E, Egwang, TG, Talisuna, AO   +17 more
core   +1 more source

Safety of sulfadoxine/pyrimethamine for intermittent preventive treatment of malaria in infants: evidence from large-scale operational research in southern Tanzania. [PDF]

, 2011
Intermittent preventive treatment with sulfadoxine/pyrimethamine (SP) is recommended for malaria prevention in infants (IPTi-SP). Serious adverse events, including Stevens-Johnson syndrome (SJS), have been reported following exposure to SP, but few ...
Schellenberg, David, Tanner, M., Kizito Shirima, Manzi, Fatuma, Hamisi, Y., Maokola, W., Marcel Tanner, Fatuma Manzi, Hassan Mshinda, Werner Maokola, Mrisho, Mwifadhi, Schellenberg, Joanna RM Armstrong, Barbara Willey, Pedro Alonso, Alonso, P., Mshinda, Hassan, Tanner, Marcel, Alonso, Pedro, Joanna R.M. Armstrong Schellenberg, Hamisi, Yuna, Schellenberg, D., Manzi, F., Yuna Hamisi, Chemba, Mwajuma, Chemba, M., Mwifadhi Mrisho, Mrisho, M., David Schellenberg, Mary Masanja, Masanja, M., Mshinda, H., Masanja, Mary, Shirima, Kizito, Willey, Barbara, Shirima, K., Willey, B., Mwajuma Chemba, Armstrong Schellenberg, J. R. M., Maokola, Werner   +38 more
core   +1 more source

Enhancing Maternal and Child Health: A Cross‐National Analysis of Nutrition Service Readiness in Sub‐Saharan Africa

Maternal &Child Nutrition, EarlyView.
Large variations exist in the availability of essential nutrition commodities and services across seven sub‐Saharan African countries, highlighting disparities in health system readiness. Despite high procurement rates for key commodities, logistical challenges impede consistent service delivery at the facilities, especially for newer interventions ...
Romance Dissieka, Djeinam Toure, Akriti Singh, Mahamadou Mansour Ndiath, Rolf D. W. Klemm   +4 more
wiley   +1 more source

Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi [PDF]

, 2009
Sulphadoxine-pyrimethamine (SP) is the only single dose therapy for uncomplicated malaria, but there is widespread resistance. At the time of this study, artemether-lumefantrine (AL) and chlorproguanil-dapsone (CPD), both multi-dose regimes, were ...
Hughes Dyfrig A, Mavuto Mukaka, Montgomery, Jacqui, Peter A Winstanley, Wootton, Dan, Winstanley Peter A, David G Lalloo, Molyneux Malcolm E, Bell, David J., Ward, Steve, Ward, Steve A., Chimpeni Phillips, Mukaka, Mavuto, Dyfrig A Hughes, Hughes, Dyfrig A., Steve A Ward, Wootton, Daniel G., Molyneux, Malcolm E., Lalloo David G, Phillips Chimpeni, Malcolm E Molyneux, Bell David J, Kayange Noel, Jacqui Montgomery, Ward Steve A, David J Bell, Noel Kayange, Mukaka Mavuto, Hughes, Dyfrig, Kayange, Noel, Lalloo, David G., Wootton Dan, Lalloo, David; id_orcid, Chimpeni, Phillips, Winstanley, Peter, Montgomery Jacqui, Dan Wootton, Winstanley, Peter A.   +37 more
core   +1 more source

A Genetically Encoded Marker for Imaging of Internal Plasmodium Membranes

Molecular Microbiology, EarlyView.
IMMP is a peptide‐based marker that labels internal membranes across multiple stages and species of the malaria‐causing parasite Plasmodium. It works in both live and fixed samples and supports long‐term live‐cell imaging. ABSTRACT Fluorescence microscopy is a powerful tool to analyze the subcellular architecture, and long‐term live‐cell imaging ...
Leah Zink, Viola Reuschenbach, Samy Sid Ahmed, Muriel Lauer, Jana Niethammer, Aistė Kudulytė, Katharina Zorko, Oliver T. Fackler, Franziska Hentzschel, Markus Ganter   +9 more
wiley   +1 more source

Plasmodium Actin‐Like Proteins 3 and 5a Are Required for Subsequent Steps of Mosquito Infection

Molecular Microbiology, EarlyView.
Actin‐like proteins (Alps) are highly conserved, apicomplexan‐specific members of the actin superfamily. Using reverse genetics, we have identified that Alp3 and Alp5a are required at separate steps of transmission of the malaria parasite to its mosquito host.
Caroline Busse, Yukino Kobayashi, Andrea Diers, Annika M. Binder, Friedrich Frischknecht, Ross G. Douglas   +5 more
wiley   +1 more source

BONCAT-iTRAQ Labelling Reveals Molecular Markers of Adaptive Responses in Toxoplasma gondii to Pyrimethamine Treatment

Pathogens
We employed a BONCAT-iTRAQ labelling approach to investigate newly synthesised proteins (NSPs) in Toxoplasma gondii subjected to varying concentrations of the antifolate drug pyrimethamine.
John G. Mina, Anutthaman Parthasarathy, Exequiel O. Porta, Paul W. Denny, Karunakaran Kalesh   +4 more
doaj   +1 more source