Results 81 to 90 of about 31,483 (223)

Artemisinin‐Based Combination Therapies in East Africa: A Systematic Review of Quality, Clinical Efficacy, and Regulatory Progress Towards Sustainable Malaria Control

Tropical Medicine &International Health, Volume 31, Issue 3, Page 254-273, March 2026.
ABSTRACT Background Malaria is a major public health issue in East Africa, leading to widespread illness and fatalities, especially among vulnerable populations such as children under 5 years of age and pregnant women. Artemisinin‐based combination therapies (ACTs) are the primary treatment modality; however, their efficacy is undermined by the ...
Yesuneh Tefera Mekasha, Addisu Afrassa Tegegne, Tapfumanei Mashe, Million Girma, Gemmechu Hasen, Sileshi Belew   +5 more
wiley   +1 more source

Strategy for Identifying Rational Sensitivity Analysis Using PBPK Modeling for Precipitant Drug–Drug Interaction Predictions

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 314-317, February 2026.
Physiology Based Pharmacokinetic (PBPK) modeling is an established essential tool for predicting and/or analyzing drug–drug interactions (DDI). Uncertainty and variability associated with in vitro determined DDI‐related parameters have often been considered a limitation for predicting PBPK‐DDIs.
Kunal S. Taskar, Pradeep Sharma, Karen Rowland Yeo   +2 more
wiley   +1 more source

Declining Burden of Malaria Over two Decades in a Rural Community of Muheza District, North-Eastern Tanzania. [PDF]

, 2013
The recently reported declining burden of malaria in some African countries has been attributed to scaling-up of different interventions although in some areas, these changes started before implementation of major interventions.
A Bhattarai, AC Ghani, AM Ronn, AS Rutta, BA Okech, BL Sharp, BP Mmbando, Bruno P Mmbando, C Karema, C Lengeler, Deus S Ishengoma, DS Ishengoma, DW Meyrowitsch, E Chizema-Kawesha, EA Okiro, EA Okiro, FO ter Kuile, G Mtove, G O'Connor, H Reyburn, HD Teklehaimanot, I Kleinschmidt, I Kleinschmidt, Ib C Bygbjerg, J Mufunda, J Picard, JC Beier, JP Lusingu, KI Barnes, M Alifrangis, M Lemnge, M Otten, Martha M Lemnge, Method D Segeja, MH Craig, MH Craig, Michael Alifrangis, Ministry of Health, Ministry of Health, MK Bouyou-Akotet, MM Lemnge, MM Lemnge, MS Hsiang, MW Aregawi, National Malaria Control Programme, P Chanda, P Winskill, PH Jakobsen, PM Graves, PM Nyarango, R Maharaj, RJ Manuel, RW Steketee, SJ Ceesay, SJ Ceesay, SM Magesa, T Bousema, T Jelinek, T Jelinek, VA Kilimali, WHO, WHO, WHO, WP O'Meara, WP O'Meara, YA Derua   +65 more
core   +2 more sources

Strongyloides Antigens Alter Cytokines Responses in Toxoplasma gondii‐Infected BeWo Trophoblast Cells

Cell Biology International, Volume 50, Issue 1, January 2026.
ABSTRACT The importance of co‐infections is not yet completely understood, and the impact and direction of their effects vary considerably. This study aimed to evaluate the role of total saline extract (TS) and excretory/secretory (ES) products of Strongyloides venezuelensis filarioid larvae on a maternal‐interface cell model during Toxoplasma gondii ...
Fabíola Teixeira Alves, Bhrenda Carolliny Guardieiro Jesus, Maria Eduarda Silva Diniz, Luana Carvalho Luz, Priscila Silva Franco, Vanessa da Silva Ribeiro, Edson Fernando Goulart de Carvalho, Bellisa Freitas Barbosa, Henrique Tomaz Gonzaga   +8 more
wiley   +1 more source

Knowledge, attitudes and practices of malaria control among communities from the health district of Forécariah in the Republic of Guinea, West Africa. [PDF]

, 2014
BACKGROUND & OBJECTIVES: Malaria is the leading cause of death in children under 5-yr of age in the Republic of Guinea. This study aimed at investigating the knowledge, attitudes and practices of malaria control in urban and rural communities in Guinea ...
Banek, Kristin, Camara, Seydouba, Loua, Marcel Kovana, Ruberto, Irene   +3 more
core   +1 more source

Examining catastrophic costs and benefit incidence of subsidized antiretroviral treatment (ART) programme in south-east Nigeria.

, 2008
OBJECTIVES: To examine the extent to which costs of subsidized antiretrovirals treatment (ART) programmes are catastrophic and the benefit incidence that accrues to different population groups.
Chukwuka, Chinwe, Dike, Nkem, Ichoku, Hyacinth, Onoka, Chima, Onwujekwe, Obinna, Onyedum, Cajetan, Uzochukwu, Benjamin   +6 more
core   +1 more source

Adherence to a Six-Dose Regimen of Artemether-Lumefantrine for Treatment of Uncomplicated Plasmodium Falciparum Malaria in Uganda. [PDF]

, 2004
Measuring baseline levels of adherence and identifying risk factors for non-adherence are important steps before the introduction of new antimalarials. In Mbarara in southwestern Uganda, we assessed adherence to artemether-lumefantrine (Coartem) in its ...
Bajunirwe, F, Biraro, S, Checchi, F, Fogg, C, Guthmann, J P, Kiguli, J, Kyomugisha, A, Musabe, J, Namiiro, P, Piola, P   +9 more
core   +2 more sources

Exploration and Characterization of the Antimalarial Activity of Pyrimidine‐2,4‐Diamines for which Resistance is Mediated by the ABCI3 Transporter

ChemMedChem, Volume 21, Issue 1, January 2026.
Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri, Madeline G. Dans, Zijun Low, Katie Loi, Kate E. Jarman, Jocelyn S. Penington, Deyun Qiu, Adele M. Lehane, Benigno Crespo, Franciso‐Javier Gamo, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs   +14 more
wiley   +1 more source

IL21—STAT3 controls the pentose phosphate pathway to support metabolic reprogramming and tumor progression in chronic lymphocytic leukemia

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Studying how microenvironmental cues influence metabolic reprogramming can uncover mechanisms driving tumor progression. Using an in vitro model with proliferative stimuli of the in vivo lymph node niche (LN)—including interleukin‐21 (IL‐21)—we examined metabolic rewiring in chronic lymphocytic leukemia (CLL) cells. We found that the metabolic
Rosita Del Prete, Vjola Tusha, Helga Simon‐Molas, Virginia Anna Gazziero, Federica Nardi, Roberta Drago, Gaia Bartolini, Danilo Licastro, Margherita Malchiodi, Cristina Mariottini, Giuseppe Marotta, Giulio Caravagna, Stefano Bruscoli, Eric Eldering, Alessandro Gozzetti, Monica Bocchia, Anna Kabanova   +16 more
wiley   +1 more source

BONCAT-iTRAQ Labelling Reveals Molecular Markers of Adaptive Responses in Toxoplasma gondii to Pyrimethamine Treatment

Pathogens
We employed a BONCAT-iTRAQ labelling approach to investigate newly synthesised proteins (NSPs) in Toxoplasma gondii subjected to varying concentrations of the antifolate drug pyrimethamine.
John G. Mina, Anutthaman Parthasarathy, Exequiel O. Porta, Paul W. Denny, Karunakaran Kalesh   +4 more
doaj   +1 more source