Results 1 to 10 of about 6,898 (170)

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils [PDF]

Advanced Science
Attenuated Salmonella VNP20009 (VNP) induces significant neutrophil recruitment in the tumor microenvironment (TME) during cancer therapy. However, the exact role of neutrophils in VNP‐mediated antitumor effects remains elusive. Here, we first identified
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
doaj   +3 more sources

The cardiovascular effects of amodiaquine and structurally related antimalarials: An individual patient data meta-analysis

PLoS Medicine, 2021
BackgroundAmodiaquine is a 4-aminoquinoline antimalarial similar to chloroquine that is used extensively for the treatment and prevention of malaria.
Xin Hui S Chan, Ilsa L Haeusler, Yan Naung Win   +2 more
exaly   +2 more sources

Population pharmacokinetics of artemether-lumefantrine plus amodiaquine in patients with uncomplicated Plasmodium falciparum malaria. [PDF]

Br J Clin Pharmacol
Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based combination therapies, TACT), consisting of two partner drugs with different mechanisms of action and similar ...
Ding J, Hoglund RM, van der Pluijm RW, Callery JJ, Peto TJ, Tripura R, Das S, Châu NH, Promnarate C, Mukaka M, Dysoley L, Fanello C, Onyamboko MA, Anvikar AR, Mayxay M, Smithuis F, von Seidlein L, Dhorda M, Amaratunga C, Faiz MA, Nghia HDT, White NJ, Day NPJ, Dondorp AM, Tarning J.   +24 more
europepmc   +2 more sources

Molecular Markers of Antimalarial Drug Resistance in Plasmodium falciparum From Kumasi, Ghana, 2023. [PDF]

Trop Med Int Health
ABSTRACT Objectives Artemisinin partial resistance has emerged in East Africa and is feared to spread across the continent, potentially compromising artemisinin‐based combination treatment. Molecular markers can serve as early warning signals for the development of specific drug resistance.
Kegya AD, Oppong E, Darko E, Boateng KA, Phillips RO, Heinemann M, Ramharter M, Igiraneza C, Ndoli JM, Mockenhaupt FP, van Loon W.   +10 more
europepmc   +2 more sources

Amodiaquine-Associated Asthenia: A Case Based Review and Gaps in Literature [PDF]

International Journal of Travel Medicine and Global Health, 2016
Introduction: Amodiaquine is a partner drug in the artemisinin-based combination therapy artesunate-amodiaquine. Reports of the adverse drug reaction known as amodiaquine-associated asthenia are scarce, and this adverse reaction needs to be investigated ...
Obaro Michael, Joseph Badejo, Adewale Bakre, Adebola Orimadegun, Olusegun Ademowo, Catherine Falade   +5 more
doaj   +1 more source

Development and Characterization of Folic Acid-Conjugated Amodiaquine-Loaded Nanoparticles–Efficacy in Cancer Treatment

Pharmaceutics, 2023
The objective of this study was to construct amodiaquine-loaded, folic acid-conjugated polymeric nanoparticles (FA-AQ NPs) to treat cancer that could be scaled to commercial production.
Vineela Parvathaneni, Snehal K. Shukla, Vivek Gupta   +2 more
doaj   +1 more source

Oral amodiaquine microparticles repurposed for the treatment of visceral leishmaniasis

Scientific African, 2022
Background: Leishmaniasis, a neglected tropical disease, is caused by parasites from the genus Leishmania and transmitted by the female phlebotamine sandfly.
Henry Nettey, Isaac Joe Erskine, Afia Antwi Mensah, Nana Kwame Ofori Gyamera, Charles Kwadwo Obuobi, Doris Kumadoh, Isaac Julius Asiedu-Gyekye, Grace Lovia Allotey-Babington   +7 more
doaj   +1 more source

Susceptibility of Colombian Plasmodium falciparum isolates to 4-aminoquinolines and the definition of amodiaquine resistance in vitro

Memorias do Instituto Oswaldo Cruz, 2006
There are wide variations in the threshold used to define in vitro resistance of Plasmodium falciparum to amodiaquine (AQ), probably due to differences in methodology and interpretation. In vitro susceptibility data of Colombian P.
Diego F Echeverry, Claribel Murillo, Restrepo P Piedad, Lyda Osorio   +3 more
doaj   +1 more source

Effects of pyrimethamine-sulphadoxine, chloroquine plus chlorpheniramine, and amodiaquine plus pyrimethamine-sulphadoxine on gametocytes during and after treatment of acute, uncomplicated malaria in children

Memorias do Instituto Oswaldo Cruz, 2006
The effects of pyrimethamine-sulphadoxine (PS), chloroquine plus chlorpheniramine, a H1 receptor antagonist that reverses chloroquine resistance in Plasmodium falciparum in vitro and in vivo (CQCP), and amodiaquine plus pyrimethamine-sulphadoxine (AQPS ...
A Sowunmi, AA Adedeji, GO Gbotosho, BA Fateye, TC Happi   +4 more
doaj   +1 more source

Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria

Malaria Journal, 2021
Background Accurate measurement of anti-malarial drug concentrations in therapeutic efficacy studies is essential to distinguish between inadequate drug exposure and anti-malarial drug resistance, and to inform optimal anti-malarial dosing in key target ...
Thomas A. Anyorigiya, Sandra Castel, Katya Mauff, Frank Atuguba, Bernhards Ogutu, Abraham Oduro, David Dosoo, Kwaku-Poku Asante, Seth Owusu-Agyei, Alexander Dodoo, Abraham Hodgson, Fred Binka, Lesley J. Workman, Elizabeth N. Allen, Paolo Denti, Lubbe Wiesner, Karen I. Barnes   +16 more
doaj   +1 more source