Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils [PDF]
Advanced ScienceAttenuated Salmonella VNP20009 (VNP) induces significant neutrophil recruitment in the tumor microenvironment (TME) during cancer therapy. However, the exact role of neutrophils in VNP‐mediated antitumor effects remains elusive. Here, we first identified
Wanfa Dong +13 more
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Field-adapted sampling of whole blood to determine the levels of amodiaquine and its metabolite in children with uncomplicated malaria treated with amodiaquine plus artesunate combination [PDF]
Malaria Journal, 2009 Background Artemisinin combination therapy (ACT) has been widely adopted as first-line treatment for uncomplicated falciparum malaria. In Uganda, amodiaquine plus artesunate (AQ+AS), is the alternative first-line regimen to Coartem® (artemether ...
Gustafsson Lars L +6 more
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Sulfadoxine-pyrimethamine–based combinations for malaria : a randomised blinded trial to compare efficacy, safety and selection of resistance in Malawi [PDF]
, 2008 Background: In Malawi, there has been a return of Plasmodium falciparum sensitivity to chloroquine (CQ) since sulfadoxinepyrimethamine (SP) replaced CQ as first line treatment for uncomplicated malaria.
David J. Bell +40 more
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Systematic review of amodiaquine treatment in uncomplicated malaria [PDF]
Lancet, The, 1996 Brasseur, P. +6 more
exaly +2 more sources
Amodiaquine-Associated Asthenia: A Case Based Review and Gaps in Literature [PDF]
International Journal of Travel Medicine and Global Health, 2016 Introduction: Amodiaquine is a partner drug in the artemisinin-based combination therapy artesunate-amodiaquine. Reports of the adverse drug reaction known as amodiaquine-associated asthenia are scarce, and this adverse reaction needs to be investigated ...
Obaro Michael +5 more
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Pharmaceutics, 2023 The objective of this study was to construct amodiaquine-loaded, folic acid-conjugated polymeric nanoparticles (FA-AQ NPs) to treat cancer that could be scaled to commercial production.
Vineela Parvathaneni +2 more
doaj +1 more source
PLoS Medicine, 2021 BackgroundAmodiaquine is a 4-aminoquinoline antimalarial similar to chloroquine that is used extensively for the treatment and prevention of malaria.
Xin Hui S Chan +16 more
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Oral amodiaquine microparticles repurposed for the treatment of visceral leishmaniasis
Scientific African, 2022 Background: Leishmaniasis, a neglected tropical disease, is caused by parasites from the genus Leishmania and transmitted by the female phlebotamine sandfly.
Henry Nettey +7 more
doaj +1 more source
Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone. [PDF]
, 2006 OBJECTIVE: In 2004, Sierra Leone adopted artesunate plus amodiaquine as first-line antimalarial treatment. We evaluated the efficacy of this combination in Kailahun, where a previous study had shown 70.2% efficacy of amodiaquine in monotherapy.
Balkan, S +8 more
core +2 more sources
Memorias do Instituto Oswaldo Cruz, 2006 There are wide variations in the threshold used to define in vitro resistance of Plasmodium falciparum to amodiaquine (AQ), probably due to differences in methodology and interpretation. In vitro susceptibility data of Colombian P.
Diego F Echeverry +3 more
doaj +1 more source