Results 21 to 30 of about 6,905 (171)

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Development of a Disease‐Specific Virtual Malaria Population for Physiologically‐Based Pharmacokinetic Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Malaria remains a major global health challenge, with an urgent need for new therapies to combat the evolving resistance to anti‐malarial treatments. Physiologically‐based pharmacokinetic (PBPK) modeling offers a promising approach to accurately predict PK, optimize dosing strategies, reduce development time and cost, and de‐risk the ...
Junjie Ding, Qi Pei, Richard M. Hoglund, Joel Tarning   +3 more
wiley   +1 more source

Efikasi Obat Kloroquine, Kina, Artesunate-SP, Artesunate-Amodiaquine, Artesunate-Lumafentrin pada Anak Malaria Falciparum di BLU RSUP Prof. Dr. RD. Kandou Manado

Sari Pediatri, 2016
Latar belakang. Malaria falciparum masih merupakan salah satu penyebab utama kematian dan kesakitan pada anak-anak dan orang dewasa di negara-negara tropis.
Suryadi Nicolaas Napoleon Tatura
doaj   +1 more source

DDIapp—A Web‐Based Application for Static Drug–Drug Interaction Assessment

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT In this work we describe the development of a web‐based application for static drug–drug interaction (DDI) risk assessment in accordance with the International Council for Harmonization (ICH) M12 guidance. The app was built using the Shiny for Python framework and it employs a modular mathematical modeling structure that incorporates models ...
Hirotaka Watase, Sylvie Klieber, Yorgos M. Psarellis, Nikhil Pillai, Panteleimon D. Mavroudis, Saroj Dhakal   +5 more
wiley   +1 more source

Low-Cost and Portable Biosensor Based on Monitoring Impedance Changes in Aptamer-Functionalized Nanoporous Anodized Aluminum Oxide Membrane

Micromachines
We report a low-cost, portable biosensor composed of an aptamer-functionalized nanoporous anodic aluminum oxide (NAAO) membrane and a commercial microcontroller chip-based impedance reader suitable for electrochemical impedance spectroscopy (EIS)-based ...
Nianyu Jiang, Pranav Shrotriya
doaj   +1 more source

A Systematic Review of Published Physiologically Based Pharmacokinetic Models for Drug Excretion Into Human Breastmilk: Knowledge Gaps and Opportunities to Optimize Reporting and Modeling Practices

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is increasingly used to predict infant exposure to medications via breast milk. Existing guidance on reporting of PBPK modeling analyses is unstructured and nonbinding to researchers. We evaluated reporting practices and modeling approaches in published PBPK modeling studies.
Joshua Kiptoo, Davies Otieno, Kenta Yoshida, Neel Deferm, Aida Nakayiwa Kawuma, Francis Williams Ojara, Adeniyi Olagunju, Jackson K. Mukonzo, Catriona Waitt   +8 more
wiley   +1 more source

Synthesis and Evaluation of Some New Isoquine Analogues for Antimalarial Activity

E-Journal of Chemistry, 2009
Amodiaquine is a 4-aminoquinoline antimalarial that can cause adverse side effects including hepatic and haematological toxicity. The drug toxicity involves the formation of an electrophilic metabolite, amodiaquine quinoneimine (AQQI), which binds to ...
Chandra Nath Saha, Sanjib Bhattacharya, Dipak Chetia   +2 more
doaj   +1 more source

Eficacia de la combinación amodiaquina más sulfadoxinapirimetamina y de la cloroquina para el tratamiento del paludismo en Córdoba, Colombia, 2006

Biomédica: revista del Instituto Nacional de Salud, 2008
Introducción. La disminución de la eficacia de los medicamentos antipalúdicos en el mundo y en Colombia, dificulta el control de la enfermedad. Objetivo.
Manuel Alberto Pérez, Liliana Jazmín Cortés, Ángela Patricia Guerra, Angélica Knudson, Carlos Usta, Rubén Santiago Nicholls   +5 more
doaj   +1 more source

Development of a Brain‐Penetrant Nurr1 Agonist Tool

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Nuclear receptor‐related 1 (Nurr1) is a ligand‐activated transcription factor with neuroprotective properties, thought to hold therapeutic potential in neurodegeneration. Here, we developed a potent, brain‐penetrant Nurr1 agonist to study the effects of pharmacological Nurr1 activation in the CNS in vivo. The ligand‐sensing transcription factor nuclear
Jan Vietor, Tanja Stiller, Christian Gege, Wael Saeb, Úrsula López‐García, Hella Kohlhof, Daniel Vitt, Daniel Merk   +7 more
wiley   +1 more source

Polimorfismos del gen pfmdr1 en muestras clínicas de Plasmodium falciparum y su relación con la respuesta terapéutica a antipalúdicos y paludismo grave en Colombia

Biomédica: revista del Instituto Nacional de Salud, 2007
Introducción. El gen pfmdr1 de Plasmodium falciparum se describió como un gen de resistencia a diversos antipalúdicos. Sin embargo, no se han estudiado el papel de su polimorfismo en la respuesta terapéutica al tratamiento con antipalúdicos en Colombia ...
Paula Montoya, Alberto Tobón, Silvia Blair, Jaime Carmona, Amanda Maestre   +4 more
doaj   +1 more source