Results 1 to 10 of about 45,170 (202)

Computational Development of Inhibitors of Plasmid-Borne Bacterial Dihydrofolate Reductase [PDF]

Antibiotics, 2022
Resistance to trimethoprim and other antibiotics targeting dihydrofolate reductase may arise in bacteria harboring an atypical, plasmid-encoded, homotetrameric dihydrofolate reductase, called R67 DHFR. Although developing inhibitors to this enzyme may be
Pedro J. Silva
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Computational identification of candidate inhibitors for Dihydrofolate reductase in Acinetobacter baumannii [PDF]

Current Research in Structural Biology
Acinetobacter baumannii is one of the emerging causes of hospital acquired infections and this bacterium, due to multi-drug resistant and Extensive Drug resistant has been able to develop resistance against the antimicrobial agents that are being used to
Saurabh Kumar Bhati, Monika Jain, Jayaraman Muthukumaran, Amit Kumar Singh   +3 more
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Oxidative degradation of dihydrofolate reductase increases CD38-mediated ferroptosis susceptibility [PDF]

Cell Death and Disease, 2022
High expression of CD38 in tissues is a characteristic of aging, resulting in a decline in nicotinamide adenine dinucleotide (NAD) and increasing cellular reactive oxygen species (ROS).
Yingying Ma, Meiqi Yi, Weixuan Wang, Xiaohui Liu, Qingtao Wang, Chongdong Liu, Yuling Chen, Haiteng Deng   +7 more
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Cymoxanil disrupts RNA synthesis through inhibiting the activity of dihydrofolate reductase [PDF]

Scientific Reports
The agricultural fungicide cymoxanil (CMX) is commonly used in the treatment of plant pathogens, such as Phytophthora infestans. Although the use of CMX is widespread throughout the agricultural industry and internationally, the exact mechanism of action
Thomas David Daniel Kazmirchuk, Daniel. J. Burnside, Jiashu Wang, Sasi Kumar Jagadeesan, Mustafa Al-gafari, Eshan Silva, Taylor Potter, Calvin Bradbury-Jost, Nishka Beersing Ramessur, Brittany Ellis, Sarah Takallou, Maryam Hajikarimlou, Houman Moteshareie, Kamaleldin B. Said, Bahram Samanfar, Eugene Fletcher, Ashkan Golshani   +16 more
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The effects of exposed Black seed (Nigella sativa L.) callus by gamma rays on specific activity of dihydrofolate reductase and folate content Extracted from it [PDF]

مجلة التربية والعلم, 2008
The present study was conducted to determine the effects of gamma rays on specific activity of dihydrofolate reductase and folate content of Black seed (Nigella sativa L.) callus. The effect was dependent on doses of gamma rays.
Sajeda Abood
doaj   +1 more source

Effects of point mutations in Plasmodium falciparum dihydrofolate reductase and dihydropterate synthase genes on clinical outcomes and in vitro susceptibility to sulfadoxine and pyrimethamine. [PDF]

PLoS ONE, 2009
Sulfadoxine-pyrimethamine was a common first line drug therapy to treat uncomplicated falciparum malaria, but increasing therapeutic failures associated with the development of significant levels of resistance worldwide has prompted change to alternative
David J Bacon, Doug Tang, Carola Salas, Norma Roncal, Carmen Lucas, Lucia Gerena, Lorena Tapia, A Alejandro Llanos-Cuentas, Coralith Garcia, Lelv Solari, Dennis Kyle, Alan J Magill   +11 more
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Dihydrofolate Reductase Is a Valid Target for Antifungal Development in the Human Pathogen Candida albicans

mSphere, 2020
While the folate biosynthetic pathway has provided a rich source of antibacterial, antiprotozoal, and anticancer therapies, it has not yet been exploited to develop uniquely antifungal agents.
Christian DeJarnette, Arturo Luna-Tapia, Leanna R. Estredge, Glen E. Palmer   +3 more
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Hypermethylation of dihydrofolate reductase promoter increases the risk of hypertension in Chinese

Journal of Research in Medical Sciences, 2020
Background: DNA methylation was considered to play an important role in hypertension. However, the direct association between dihydrofolate reductase (DHFR) promoter methylation and hypertension remains unclear.
Guodong Xu, Zhiyi Wang, Lian Li, Wenxia Li, Jingcen Hu, Shuyu Wang, Hongxia Deng, Bo Li, Changyi Wang, Zhishen Shen, Liyuan Han   +10 more
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Identification of the molecular mechanism of christinin compounds from Arabian bidara leaves (Ziziphus spina-christi L.) on microorganisms that cause female genital problems through computational approaches [PDF]

Pharmaciana, 2020
Arabian bidara leaves (Ziziphus spina-christi, L.) are known to have strong antimicrobial activity against microorganisms that cause infection in the female genital area, namely Staphylococcus aureus bacteria and Candida albicans fungi. They contain main
Fitrianti Darusman, Taufik Muhammad Fakih   +1 more
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Divergent evolution of protein conformational dynamics in dihydrofolate reductase. [PDF]

, 2013
Molecular evolution is driven by mutations, which may affect the fitness of an organism and are then subject to natural selection or genetic drift. Analysis of primary protein sequences and tertiary structures has yielded valuable insights into the ...
Bhabha, Gira, Dyson, H Jane, Ekiert, Damian C, Godzik, Adam, Jennewein, Madeleine, Kroon, Gerard, Tuttle, Lisa M, Wilson, Ian A, Wright, Peter E, Zmasek, Christian M   +9 more
core   +2 more sources