Results 21 to 30 of about 22,882 (212)

Anticancer Activity of Pyrimethamine via Ubiquitin Mediated Degradation of AIMP2-DX2

Molecules, 2020
While aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) is a tumor suppressor, its exon 2-depleted splice variant (AIMP2-DX2 or shortly DX2) is highly expressed in human lung cancer, and the ratio of DX2 to AIMP2 increases according
Dae Gyu Kim, Chul Min Park, Srigouri Huddar, Semi Lim, Sunghoon Kim, Sunkyung Lee   +5 more
doaj   +1 more source

Validation of PfSNP-LAMP-Lateral Flow Dipstick for Detection of Single Nucleotide Polymorphism Associated with Pyrimethamine Resistance in Plasmodium falciparum

Diagnostics, 2020
The loop-mediated isothermal amplification coupled with lateral flow dipstick (PfSNP-LAMP-LFD) was recently developed to detect single nucleotide polymorphism (AAT → ATT), corresponding to substitution of asparagine to isoleucine at amino acid position ...
Suganya Yongkiettrakul, Fassou René Kolié, Darin Kongkasuriyachai, Jetsumon Sattabongkot, Wang Nguitragool, Namfon Nawattanapaibool, Chayanut Suansomjit, Saradee Warit, Niwat Kangwanrangsan, Sureemas Buates   +9 more
doaj   +1 more source

Drug coverage in treatment of malaria and the consequences for resistance evolution--evidence from the use of sulphadoxine/pyrimethamine. [PDF]

, 2010
BACKGROUND\ud \ud It is argued that, the efficacy of anti-malarials could be prolonged through policy-mediated reductions in drug pressure, but gathering evidence of the relationship between policy, treatment practice, drug pressure and the evolution of ...
Abdulla, Salim, Bloland, Peter, Malisa, Allen L, Roper, Cally, Allen L Malisa, Salim Abdulla, Cally Roper, Patrick S Kachur, Peter Bloland, Hassan Mshinda, Kachur, Patrick S, Richard J Pearce, Pearce, Richard J, Mshinda, Hassan   +13 more
core   +1 more source

The evolution of pyrimethamine resistant dhfr in Plasmodium falciparum of south-eastern Tanzania: comparing selection under SP alone vs SP+artesunate combination. [PDF]

, 2011
BACKGROUND\ud \ud Sulphadoxine-pyrimethamine (SP) resistance is now widespread throughout east and southern Africa and artemisinin compounds in combination with synthetic drugs (ACT) are recommended as replacement treatments by the World Health ...
Salim Abdullah, Mutayoba, Ben M, Bloland, Peter, Roper Cally, Malisa, Allen L, Roper, Cally, Allen L Malisa, Abdullah Salim, Cally Roper, Patrick S Kachur, Peter Bloland, Pearce Richard J, Hassan Mshinda, Bloland Peter, Kachur, Patrick S, Mshinda Hassan, Kachur Patrick S, Ben M Mutayoba, Malisa Allen L, Richard J Pearce, Abdullah, Salim, Pearce, Richard J, Mshinda, Hassan, Mutayoba Ben M   +23 more
core   +1 more source

Molecular monitoring of the Leu-164 mutation of dihydrofolate reductase in a highly sulfadoxine/pyrimethamine-resistant area in Africa. [PDF]

, 2003
The selection of point mutation at codon 164 (from isoleucine to leucine) of the dihydrofolate reductase (DHFR) enzyme in Plasmodium falciparum is associated with high sulfadoxine /pyrimethamine (SP) resistance.
Watkins, W, Kimani, S, Kimani Serah, Kokwaro, Gilbert, Nzila, A, Mutabingwa, T, Kevin Marsh, Theonest Mutabingwa, Serah Kimani, Mutabingwa, Theonest, Gilbert Kokwaro, Nzila Alexis, Ochong, Edwin, Nzila, Alexis, Edwin Ochong, Kokwaro Gilbert, Kimani, Serah, Marsh Kevin, Marsh, K, Ochong Edwin, Alexis Nzila, Watkins, William, William Watkins, Kokwaro, G, Watkins William, Marsh, Kevin, Mutabingwa Theonest, Ochong, E   +27 more
core   +1 more source

Genomic characterization of Plasmodium falciparum genes associated with anti-folate drug resistance and treatment outcomes in eastern India: A molecular surveillance study from 2008 to 2017

Frontiers in Cellular and Infection Microbiology, 2022
IntroductionAfter being used vigorously for the previous two decades to treat P. falciparum, chloroquine and sulfadoxine-pyrimethamine were replaced in 2009 with an artemisinin-based combination therapy (artesunate-sulfadoxine-pyrimethamine) in an effort
Sabyasachi Das, Sabyasachi Das, Satyajit Tripathy, Ankita Das, Meenakshi Kumari Sharma, Ayan Nag, Amiya Kumar Hati, Somenath Roy   +7 more
doaj   +1 more source

Understanding the Pyrimethamine Drug Resistance Mechanism via Combined Molecular Dynamics and Dynamic Residue Network Analysis

Molecules, 2020
In this era of precision medicine, insights into the resistance mechanism of drugs are integral for the development of potent therapeutics. Here, we sought to understand the contribution of four point mutations (N51I, C59R, S108N, and I164L) within the ...
Arnold Amusengeri, Rolland Bantar Tata, Özlem Tastan Bishop   +2 more
doaj   +1 more source

Methylene blue inhibits lumefantrine-resistant Plasmodium berghei

Journal of Infection in Developing Countries, 2016
Introduction: Chemotherapy still is the most effective way to control malaria, a major public health problem in sub-Saharan Africa. The large-scale use of the combination therapy artemether-lumefantrine for malaria treatment in Africa predisposes ...
Victor Irungu Mwangi, Ruth Mwende Mumo, Daniel Muthui Kiboi, Sabah Ahmed Omar, Zipporah Waithera Ng'ang'a, Hastings Suba Ozwara   +5 more
doaj   +1 more source

Nationwide Monitoring for Plasmodium falciparum Drug-Resistance Alleles to Chloroquine, Sulfadoxine, and Pyrimethamine, Haiti, 2016–2017

Emerging Infectious Diseases, 2020
Haiti is striving for zero local malaria transmission by the year 2025. Chloroquine remains the first-line treatment, and sulfadoxine/pyrimethamine (SP) has been used for mass drug-administration pilot programs.
Eric Rogier, Camelia Herman, Curtis S. Huber, Karen E.S. Hamre, Baby Pierre, Kimberly E. Mace, Jacquelin Présumé, Gina Mondélus, Ithamare Romilus, Tamara Elismé, Thomas P. Eisele, Thomas Druetz, Alexandre Existe, Jacques Boncy, Jean F. Lemoine, Venkatachalam Udhayakumar, Michelle A. Chang   +16 more
doaj   +1 more source

Drug resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum malaria in Mlimba, Tanzania. [PDF]

, 2006
BACKGROUND\ud \ud Sulphadoxine-pyrimethamine (SP) has been and is currently used for treatment of uncomplicated Plasmodium falciparum malaria in many African countries.
Mbugi, Erasto V, Balthazary Sakurani T, Malisa, Allen L, Mbugi Erasto V, Allen L Malisa, Nyambo, Thomas B, Nyambo, T.B., Mutayoba, B.M., Mutayoba Benezeth M, Nyambo Thomas B, Balthazary, Sakurani T, Erasto V Mbugi, Balthazary, S.T., Hassan Mshinda, Mshinda, H., Mshinda Hassan, Benezeth M Mutayoba, Sakurani T Balthazary, Malisa Allen L, Mutayoba, Benezeth M, Mbugi, E.V., Thomas B Nyambo, Mshinda, Hassan, Malisa, A.L.   +23 more
core   +1 more source