Results 21 to 30 of about 16,294 (175)
Altered life history strategies protect malaria parasites against drugs
Evolutionary Applications, 2018 Drug resistance has been reported against all antimalarial drugs, and while parasites can evolve classical resistance mechanisms (e.g., efflux pumps), it is also possible that changes in life history traits could help parasites evade the effects of ...
Philip L. G. Birget +3 more
doaj +1 more source
AntibioticsBackground/Objectives: Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii. The parasite infection in humans continues to rise due to an increasing seroprevalence rate in domestic and wild warm-blooded animals that serve as a major reservoir ...
Nicole T. Green-Ross +5 more
doaj +1 more source
Biomédica: revista del Instituto Nacional de Salud, 2008 Introducción. La disminución de la eficacia de los medicamentos antipalúdicos en el mundo y en Colombia, dificulta el control de la enfermedad. Objetivo.
Manuel Alberto Pérez +5 more
doaj +1 more source
Parasite, 2001 Plasmodium falciparum gametocytaemia was studied in 266 Senegalese children (median 4 years, range 0.5-16) with uncomplicated malaria treated with chloroquine (CQ), amodiaquine (AQ) or sulfadoxine+pyrimethamine (SP).
Sokhina C.S, Trape J.-F, Robert V.
doaj +1 more source
Gametocitemia en malaria por Plasmodium falciparum tratada con amodiaquina o artesunato
Biomédica: revista del Instituto Nacional de Salud, 2008 Introducción. Las relaciones de la gametocitemia de Plasmodium falciparum con el tratamiento antipalúdico han sido poco estudiadas en América. Objetivo.
Jaime Carmona-Fonseca +2 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Regulatory agencies request the assessment of the potential of new drugs to cause transporter‐mediated drug‐drug interactions (DDI). This assessment can be improved by integrating endogenous biomarkers during drug development. Regarding the renal excretion of drugs such as metformin, the organic cation transporter (OCT) 2 and multidrug and toxin ...
Jana Picurová +5 more
wiley +1 more source
Perspective for the reproduction of antimalarial drugs in Brazil
Memorias do Instituto Oswaldo Cruz, 1992 The appears to be no chemical manufacture of antimalarial drugs is Brazil. Technology at laboratory process level has been developed for chloroquine, mefloquine, pyrimethamine and cycloquanil, but not perfected nor scaled-up, largely for economic reasons
Benjamin Gilbert
doaj +1 more source
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Options for clinical trials of pre and post-natal treatments for congenital toxoplasmosis
Memorias do Instituto Oswaldo Cruz, 2009 Clinical trials comparing different drug regimens and strategies for the treatment of congenital toxoplasmosis and its clinical manifestations in the liveborn child in different clinical settings should aim at formally evaluating the net benefit of ...
Geneviève Chêne, Rodolphe Thiébaut
doaj +1 more source
Transgenic selection and underlying mechanisms in apicomplexan parasites
The FEBS Journal, EarlyView.Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju +2 more
wiley +1 more source