A new effective antiplasmodial compound: Nanoformulated pyrimethamine
Journal of Global Antimicrobial Resistance, 2020 Objectives: The aim of this study was to evaluate the efficacy of pyrimethamine-loaded poloxamer 407 nanomicelles on Plasmodium berghei strain NICD in vivo.
Jaleh Varshosaz +2 more
exaly +5 more sources
Comparative efficacy of free and PNAGA-encapsulated antimalarial drugs: temperature-dependent modulation of Plasmodium falciparum growth [PDF]
Frontiers in PharmacologyIntroductionPoly(N-acryloyl glycinamide) (PNAGA) was evaluated as a temperature-responsive carrier for antimalarial drugs.MethodsPNAGA was synthesized and characterized by DSC and TGA, and its sol–gel transition was determined by the reverse test-tube ...
Daniel Mutangadura +2 more
doaj +2 more sources
Treatment of congenital toxoplasmosis with pyrimethamine combined with sulfadiazine in a Chinese neonate: a case report [PDF]
Frontiers in PediatricsThis work reports a case of neonatal congenital toxoplasmosis in which the standard regimen of pyrimethamine combined with sulfadiazine was administered under conditions of limited drug accessibility in China, with multidisciplinary collaboration and ...
Ya Hu +9 more
doaj +2 more sources
Effects of Trimethoprim on Three Previously Proposed Putative Biomarkers for OCT2/MATE-Mediated Renal Drug-Drug Interactions in Healthy Volunteers. [PDF]
Clin Pharmacol TherRegulatory agencies request the assessment of the potential of new drugs to cause transporter‐mediated drug‐drug interactions (DDI). This assessment can be improved by integrating endogenous biomarkers during drug development. Regarding the renal excretion of drugs such as metformin, the organic cation transporter (OCT) 2 and multidrug and toxin ...
Picurová J +5 more
europepmc +2 more sources
Effects of Drug Resistance on the Global Spread of Malaria: A Systematic Literature Review. [PDF]
Health Sci RepABSTRACT Background and Aims Malaria remains a major health crisis in tropical regions, with Sub‐Saharan Africa bearing the heaviest burden. While insecticide‐treated nets and artemisinin‐based combination therapies (ACTs) have reduced cases, emerging parasite resistance to artemisinin threatens these gains. This review synthesizes evidence on how drug
Woime AW.
europepmc +2 more sources
Pharmaceuticals, 2021 Trypanosoma and Leishmania parasites are the etiological agents of various threatening neglected tropical diseases (NTDs), including human African trypanosomiasis (HAT), Chagas disease, and various types of leishmaniasis.
Giusy Tassone +8 more
doaj +1 more source
Dihydrofolate Reductase Inhibitors: The Pharmacophore as a Guide for Co-Crystal Screening
Molecules, 2021 In this work, co-crystal screening was carried out for two important dihydrofolate reductase (DHFR) inhibitors, trimethoprim (TMP) and pyrimethamine (PMA), and for 2,4-diaminopyrimidine (DAP), which is the pharmacophore of these active pharmaceutical ...
João A. Baptista +7 more
doaj +1 more source
Pioneer Use of Antimalarial Transdermal Combination Therapy in Rodent Malaria Model
Pathogens, 2023 We have previously reported 1,2,6,7-tetraoxaspiro [7.11]nonadecane (N-89) as a promising antimalarial compound. In this study, we evaluated the effect of transdermal therapy (tdt) of N-89 in combination (tdct) with other antimalarials as an application ...
Nagwa S. M. Aly +8 more
doaj +1 more source
Immune responses to "Plasmodium falciparum" in Mozambican infants receiving Intermittent Preventive Treatment with Sulfadoxine Pyrimethamine [PDF]
, 2011 Malaria has a high toll on the lives of infants and children under the age of five in endemic areas. Control, and more recently, elimination agendas consist on implementing several measures simultaneously, including vector control, vaccines and drugs ...
Silveira Quelhas, Diana Iris
core +6 more sources
Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability
Disease Models & Mechanisms, 2021 Vascular permeability triggered by inflammation or ischemia promotes edema, exacerbates disease progression and impairs tissue recovery. Vascular endothelial growth factor (VEGF) is a potent inducer of vascular permeability.
Li Wang +7 more
doaj +1 more source