Results 11 to 20 of about 16,277 (176)

Methylene blue inhibits lumefantrine-resistant Plasmodium berghei

Journal of Infection in Developing Countries, 2016
Introduction: Chemotherapy still is the most effective way to control malaria, a major public health problem in sub-Saharan Africa. The large-scale use of the combination therapy artemether-lumefantrine for malaria treatment in Africa predisposes ...
Victor Irungu Mwangi, Ruth Mwende Mumo, Daniel Muthui Kiboi, Sabah Ahmed Omar, Zipporah Waithera Ng'ang'a, Hastings Suba Ozwara   +5 more
doaj   +1 more source

Nationwide Monitoring for Plasmodium falciparum Drug-Resistance Alleles to Chloroquine, Sulfadoxine, and Pyrimethamine, Haiti, 2016–2017

Emerging Infectious Diseases, 2020
Haiti is striving for zero local malaria transmission by the year 2025. Chloroquine remains the first-line treatment, and sulfadoxine/pyrimethamine (SP) has been used for mass drug-administration pilot programs.
Eric Rogier, Camelia Herman, Curtis S. Huber, Karen E.S. Hamre, Baby Pierre, Kimberly E. Mace, Jacquelin Présumé, Gina Mondélus, Ithamare Romilus, Tamara Elismé, Thomas P. Eisele, Thomas Druetz, Alexandre Existe, Jacques Boncy, Jean F. Lemoine, Venkatachalam Udhayakumar, Michelle A. Chang   +16 more
doaj   +1 more source

Evaluation of Dihydrofolate Reductase (Dhfr) Gene, Related to Plasmodium Falciparum Pyrimethamine Resistance in Imported Malaria Cases in Iran

Research in Molecular Medicine, 2021
Background: Antimalarial drug resistance is one of the important challenges for governments in the fight against malaria. Molecular surveillance of antimalarial drug resistance supports early detection of how the recommended treatments work.
Seyyed Ali Shariatzadeh, Reza Valadan, Seyed Abdollah Hosseini, Adel Spotin, Abbas Shahbazi, Davood Anvari, Fattaneh Montazeri, Javad Javidnia, Shirzad Gholami   +8 more
doaj  

Audit of failure rate of sulfadoxine/pyrimetham combined with chloroquine to treat falciparum malaria at single fourteen-day follow-up

South African Family Practice, 2002
Objective: To assess the failure rate of the present first line treatment regime for uncomplicated falciparum malaria of sulfadoxine/pyrimethamine combined with chloroquine. Design: A before-after study. Setting: Ndumo Clinic, Ingwavuma District, South
C.H. Vaughan Williams, C. La Cock, G.F.J. Henry, A.J. Ross   +3 more
doaj   +1 more source

Pyrimethamine Elicits Antitumor Effects on Prostate Cancer by Inhibiting the p38-NF-κB Pathway

Frontiers in Pharmacology, 2020
Since incurable castration-resistant prostate cancer (CRPC) inevitably develops following treatment with androgen deprivation therapy, there is an urgent need to devise new therapeutic strategies to treat this cancer.
Xumin Zhou, Xumin Zhou, Jinming Zhang, Xiaoping Hu, Peiqing He, Jianyu Guo, Jun Li, Tian Lan, Jumei Liu, Lilan Peng, Hua Li   +10 more
doaj   +1 more source

Effects of pyrimethamine-sulphadoxine, chloroquine plus chlorpheniramine, and amodiaquine plus pyrimethamine-sulphadoxine on gametocytes during and after treatment of acute, uncomplicated malaria in children

Memorias do Instituto Oswaldo Cruz, 2006
The effects of pyrimethamine-sulphadoxine (PS), chloroquine plus chlorpheniramine, a H1 receptor antagonist that reverses chloroquine resistance in Plasmodium falciparum in vitro and in vivo (CQCP), and amodiaquine plus pyrimethamine-sulphadoxine (AQPS ...
A Sowunmi, AA Adedeji, GO Gbotosho, BA Fateye, TC Happi   +4 more
doaj   +1 more source

IN VIVO ASSESSMENT OF THE EFFECTS OF METHOTREXATE ON LATENT TOXOPLASMOSIS [PDF]

Journal of the Egyptian Society of Parasitology, 2017
Toxoplasma gondii (T. gondii) has been shown to result in life-threatening encephalitis in immunocompromised patients after reactivation of dormant parasites.
EMAN SAAD, EMAN ABDEL BARY, MOHAMED SARHAN, MAHMOUD EL-SHAFEY, MAI ABD EL-AZEEM, DALIA ABO EL-MAATY, SAMIA ETEWA   +6 more
doaj   +1 more source

Mutaciones puntuales en los genes dhfr y dhps de Plasmodium falciparum de tres regiones endémicas

Biomédica: revista del Instituto Nacional de Salud, 2010
Introducción. La acumulación progresiva de mutaciones en los genes dhfr y dhps lleva al parásito Plasmodium falciparum a evadir la acción de la sulfadoxina-pirimetamina, situación que aumenta el nivel de resistencia del parásito a estos medicamentos y ...
John Alexander Galindo, Fabio Aníbal Cristiano, Angélica Knudson, Rubén Santiago Nicholls, Ángela Patricia Guerra   +4 more
doaj   +1 more source

Decreasing burden of malaria in pregnancy in Malawian women and its relationship to use of intermittent preventive therapy or bed nets. [PDF]

PLoS ONE, 2010
The World Health Organization recommends insecticidal bednets and intermittent preventive treatment to reduce malaria in pregnancy. Longitudinal data of malaria prevalence and pregnancy outcomes are valuable in gauging the impact of these antimalarial ...
Gaoqian Feng, Julie A Simpson, Ebbie Chaluluka, Malcolm E Molyneux, Stephen J Rogerson   +4 more
doaj   +1 more source

Risk of Congenital Toxoplasmosis in Newborns from Mothers with Documented Infection: Experience from Two Referral Centres

Pathogens
During pregnancy, primary Toxoplasma gondii infection can cause congenital toxoplasmosis (CT). We described the newborns’ outcomes from a multicentre cohort of mothers with seroconversion (SC) at different gestational ages.
Alice Bonetti, Agnese Comelli, Annacarla Chiesa, Vania Spinoni, Ambra Vola, Federico Prefumo, Adriana Valcamonico, Carlo Bonfanti, Silvio Caligaris, Lina Rachele Tomasoni, Fausto Baldanti, Valeria Meroni   +11 more
doaj   +1 more source