Results 11 to 20 of about 31,483 (223)
A new effective antiplasmodial compound: Nanoformulated pyrimethamine
Journal of Global Antimicrobial Resistance, 2020 Objectives: The aim of this study was to evaluate the efficacy of pyrimethamine-loaded poloxamer 407 nanomicelles on Plasmodium berghei strain NICD in vivo.
Jaleh Varshosaz, Hamed Kalani
exaly +3 more sources
Dihydroartemisinin-piperaquine plus sulfadoxine-pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: A double-blind, randomized, controlled phase 3 trial from Uganda. [PDF]
PLoS MedicineBackgroundTo mitigate adverse consequences of malaria in pregnancy, the World Health Organization recommends intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine.
Abel Kakuru +18 more
doaj +2 more sources
Pharmaceuticals, 2021 Trypanosoma and Leishmania parasites are the etiological agents of various threatening neglected tropical diseases (NTDs), including human African trypanosomiasis (HAT), Chagas disease, and various types of leishmaniasis.
Giusy Tassone +8 more
doaj +1 more source
Dihydrofolate Reductase Inhibitors: The Pharmacophore as a Guide for Co-Crystal Screening
Molecules, 2021 In this work, co-crystal screening was carried out for two important dihydrofolate reductase (DHFR) inhibitors, trimethoprim (TMP) and pyrimethamine (PMA), and for 2,4-diaminopyrimidine (DAP), which is the pharmacophore of these active pharmaceutical ...
João A. Baptista +7 more
doaj +1 more source
Pioneer Use of Antimalarial Transdermal Combination Therapy in Rodent Malaria Model
Pathogens, 2023 We have previously reported 1,2,6,7-tetraoxaspiro [7.11]nonadecane (N-89) as a promising antimalarial compound. In this study, we evaluated the effect of transdermal therapy (tdt) of N-89 in combination (tdct) with other antimalarials as an application ...
Nagwa S. M. Aly +8 more
doaj +1 more source
Anticancer Activity of Pyrimethamine via Ubiquitin Mediated Degradation of AIMP2-DX2
Molecules, 2020 While aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) is a tumor suppressor, its exon 2-depleted splice variant (AIMP2-DX2 or shortly DX2) is highly expressed in human lung cancer, and the ratio of DX2 to AIMP2 increases according
Dae Gyu Kim +5 more
doaj +1 more source
Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability
Disease Models & Mechanisms, 2021 Vascular permeability triggered by inflammation or ischemia promotes edema, exacerbates disease progression and impairs tissue recovery. Vascular endothelial growth factor (VEGF) is a potent inducer of vascular permeability.
Li Wang +7 more
doaj +1 more source
Molecules, 2020 In this era of precision medicine, insights into the resistance mechanism of drugs are integral for the development of potent therapeutics. Here, we sought to understand the contribution of four point mutations (N51I, C59R, S108N, and I164L) within the ...
Arnold Amusengeri +2 more
doaj +1 more source
Emerging Infectious Diseases, 2020 Haiti is striving for zero local malaria transmission by the year 2025. Chloroquine remains the first-line treatment, and sulfadoxine/pyrimethamine (SP) has been used for mass drug-administration pilot programs.
Eric Rogier +16 more
doaj +1 more source
Pyrimethamine Elicits Antitumor Effects on Prostate Cancer by Inhibiting the p38-NF-κB Pathway
Frontiers in Pharmacology, 2020 Since incurable castration-resistant prostate cancer (CRPC) inevitably develops following treatment with androgen deprivation therapy, there is an urgent need to devise new therapeutic strategies to treat this cancer.
Xumin Zhou +10 more
doaj +1 more source