Results 181 to 190 of about 8,779 (206)
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Medical Journal of Australia, 1977
A case of profound neutropenia and severe infection after the administration of amodiaquine is presented. The recommended dose for malaria prophylaxis was administered.
P, Gillespie, F, Wagner
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A case of profound neutropenia and severe infection after the administration of amodiaquine is presented. The recommended dose for malaria prophylaxis was administered.
P, Gillespie, F, Wagner
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Archives of Ophthalmology, 1982
A 34-year-old man ingested more then 250 g of amodiaquine hydrochloride (for pain) during one year and was noted to have diffuse conjunctival, corneal, and skin changes and also abnormal results from retinal function tests. Ultrastructural examination of corneal and conjunctival biopsy specimens revealed intralysosomal membranous and amorphous ...
W. Richard Green +4 more
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A 34-year-old man ingested more then 250 g of amodiaquine hydrochloride (for pain) during one year and was noted to have diffuse conjunctival, corneal, and skin changes and also abnormal results from retinal function tests. Ultrastructural examination of corneal and conjunctival biopsy specimens revealed intralysosomal membranous and amorphous ...
W. Richard Green +4 more
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Immunogenicity of Amodiaquine in the Rat
International Archives of Allergy and Immunology, 1990Amodiaquine is an antimalarial drug that has been associated with adverse reactions which may be immune mediated. Specific IgG anti-amodiaquine antibodies were detected after administration of the drug to rats (269 μmol/kg for 4 days), using an enzyme-linked immunosorbent assay employing amodiaquine conjugated to metallothionein as an antigen.
J.B. Clarke +3 more
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Life Sciences, 1985
Existing analytical methods for assaying the 4-aminoquinoline antimalarial amodiaquine in body fluids are nonspecific and obscure the fact that little or no amodiaquine is present in the blood of dosed persons. We have isolated four metabolites of amodiaquine. The two major metabolites have been identified; one is desethylamodiaquine, and the other has
Ira K. Schwartz +5 more
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Existing analytical methods for assaying the 4-aminoquinoline antimalarial amodiaquine in body fluids are nonspecific and obscure the fact that little or no amodiaquine is present in the blood of dosed persons. We have isolated four metabolites of amodiaquine. The two major metabolites have been identified; one is desethylamodiaquine, and the other has
Ira K. Schwartz +5 more
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Pharmacogenomics, 2008
Amodiaquine is a central drug in the new global strategy of combination therapies for the control of malaria. Amodiaquine is mainly metabolized hepatically towards its major active metabolite desethylamodiaquine, by the polymorphic P450 isoform CYP2C8.
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Amodiaquine is a central drug in the new global strategy of combination therapies for the control of malaria. Amodiaquine is mainly metabolized hepatically towards its major active metabolite desethylamodiaquine, by the polymorphic P450 isoform CYP2C8.
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Amodiaquine – Induced Thrombocytopenia
Highland Medical Research Journal, 2005We present a case of Amodiaquine induced severe thrombocytopenia in male 30 year old Nigerian accountant who has had previous episodes of bleeding diathesis associated with Amodiaquine ingestion. He was managed with prednisolone therapy and did not receive any blood or blood products since platelet concentrate was unavailable.
Chijioke A. Nwauche, OA Ejele
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Amodiaquine‐induced immune agranulocytosis
British Journal of Haematology, 1989SummaryThis report describes two patients who developed agranulocytosis while receiving prophylactic amodiaquine treatment. The neutrophil counts returned to normal in one after stopping the drug while the other died of sepsis. Amodiaquine‐dependent circulating neutrophil IgG antibodies were demonstrated in both patients using the indirect granulocyte ...
Laure Coulombel +4 more
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Nearly Fatal Reaction to Amodiaquine
JAMA, 1962With the expanded use of antimalarial drugs based upon their effectiveness as anti-inflammatory agents, an increase in the number of adverse reactions to these agents was to be expected. This report describes the development of hepatitis and agranulocytosis in a patient who received amodiaquine, one of the newer antimalarials, and emphasizes the ...
Lloyd G. Bartholomew +2 more
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Amodiaquine-induced fulminant hepatitis
Journal of Hepatology, 1988Three patients suffered from fulminant hepatitis within 23, 59 and 22 weeks after having ingested a total dose of 16, 26 and 15 g, respectively, of amodiaquine for the prophylaxis of malaria. Amodiaquine administration was continued for 44, 21 and 25 days after the onset of jaundice, respectively.
Bernard Rueff +7 more
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Pigmentation from amodiaquine simulating cyanosis
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1963Abstract A patient is described who on small weekly doses of amodiaquine hydrochloride developed wide-spread vivid blue pigmentation of the skin and buccal mucosa, so strikingly intense and diffuse that the initial clinical diagnosis was enterogenous cyanosis. Skin biopsy suggested the true nature of the condition.
J. Charles Shee, P.J. Barnard
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