Results 61 to 70 of about 97,097 (205)

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

Clinical Pharmacology &Therapeutics, EarlyView.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano, Aleksandra Galetin, Yoshiko Tomita, Kathleen M. Giacomini, Xiaoyan Chu, Xinning Yang, Toshimichi Nakamura, Hiroyuki Kusuhara, Yuichi Sugiyama   +8 more
wiley   +1 more source

Risk of Infections with SGLT2 Inhibitors Versus DPP4 Inhibitors: A Population‐Based Cohort Study Using Antibiotic Dispensing Data

Clinical Pharmacology &Therapeutics, EarlyView.
This study compared the number and cumulative dose of antibiotic dispensings among new users of sodium–glucose cotransporter‐2 (SGLT2) inhibitors and dipeptidyl peptidase‐4 (DPP4) inhibitors following hospital discharge in individuals with type 2 diabetes.
Maria J. Alfonso Arvez, George S. Q. Tan, Sam Wade, Zanfina Ademi, Jenni Ilomäki, J. Simon Bell   +5 more
wiley   +1 more source

Mini-Tablets versus Nanoparticles for Controlling the Release of Amoxicillin: In vitro/In vivo Study

Drug Design, Development and Therapy, 2020
Dalia A Gaber,1,2 Hessah S Alhawas,3 Fatimah A Alfadhel,3 Siham A Abdoun,1,4 Amal M Alsubaiyel,1 Rehab M Alsawi5 1Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraidah, kingdom of saudi arabia; 2Department of Quality Control &
Gaber DA, Alhawas HS, Alfadhel FA, Abdoun SA, Alsubaiyel AM, Alsawi RM   +5 more
doaj  

H. pylori eradication therapy: impact of gastric mucosa atrophy on transport of amoxicillin to H. pylori colonization area

, 2021
Anastasiya O. Sablina, Oleg A. Sablin, Julia V. Andreeva, Gennadii G. Rodionov, I I Shantyr, Inna E. Ushal, Igor A. Samusenko, Anastasiya O. Sablina, Oleg A. Sablin, Julia V. Andreeva, Gennadii G. Rodionov, I I Shantyr, Inna E. Ushal, Igor A. Samusenko   +13 more
openalex   +1 more source

Using Cenobamate for managing idiopathic generalized epilepsy: A single‐center experience and systematic literature review

Epilepsia Open, EarlyView.
Abstract Objective To evaluate the single‐center experience of Cenobamate's (CNB) off‐label use in adults with idiopathic generalized epilepsy (IGE). Methods We conducted a retrospective review of electronic health records within a large healthcare system to identify IGE patients prescribed CNB.
Nicole Woodrich, Andreas Alexopoulos, Dileep Nair, Imad M. Najm, Vineet Punia   +4 more
wiley   +1 more source

Effect of Iron Oxide Nanoparticles and Amoxicillin on Bacterial Growth in the Presence of Dissolved Organic Carbon

Biomedicines, 2017
The impact of emerging contaminants in the presence of active pharmaceutical pollutants plays an important role in the persistence and activity of environmental bacteria.
Kelley M. Current, Niluka M. Dissanayake, Sherine O. Obare   +2 more
doaj   +1 more source

Anti‐Inflammatory Effects of Flavonoids in Otitis Media: A Systematic Review of Pre‐Clinical Evidence

Food Frontiers, EarlyView.
Otitis media (OM) is a middle ear infection driven by chronic inflammation, leading to tissue damage and complications such as cholesteatoma. Flavonoids, a class of polyphenols with anti‐inflammatory properties, suppress key inflammatory mediators, reducing neutrophilic infiltration and mucosal thickening. These findings suggest flavonoids as potential
Madiha Ajaz, Ayesha Zahid, Hazrat Ismail, Misbah Ajaz   +3 more
wiley   +1 more source

Iron Ion‐Mediated Nitrogen‐Doped Carbon Dot Fluorescence Sensing for Accurate Detection of Fluoroquinolone in Food

Food Frontiers, EarlyView.
Schematic mechanism of iron‐ion mediated N‐CDs sensing for the detection of fluoroquinolones. ABSTRACT Safety incidents involving the presence of fluoroquinolones (FQs) residues in animal‐derived food are frequently reported, posing a significant threat to human health.
Jinyan Luo, Yulong Han, Zikang Hu, Guanghua Lei, Huanhuan Lu, Hengye Chen, Li Yang, Xinming Lv, Wanjun Long, Haiyan Fu   +9 more
wiley   +1 more source

Trends of antibiotic resistance of Helicobacter pylori in Moscow

Терапевтический архив
Aim. To determine the trends of primary antibiotic resistance of Helicobacter pylori strains isolated from patients living in Moscow. Materials and methods. As part of a clinical and laboratory study, 123 gastric biopsy specimens from H.
Igor V. Maev, Dmitry N. Andreev, Aleksei K. Fomenko, Mikhail S. Podporin, Svetlana V. Lyamina, Andrew V. Zaborovsky, Irina N. Khimina, Sergei V. Cheremushkin, Armine S. Bagdasarian, Natalia V. Cheremushkina, Elena G. Lobanova, Victor N. Tsarev, Oleg V. Zayratyants   +12 more
doaj   +1 more source

Methyl 5-(4-hydroxyphenyl)-6-oxo-1,6-dihydropyrazine-2-carboxylate

IUCrData, 2016
The title compound, C12H10N2O4, is approximately planar, with dihedral angles of 5.53 (9) and 2.48 (13)°, respectively, between the benzene and pyrazine rings, and between the pyrazine ring and the methyl carboxylate plane.
Naser Eltaher Eltayeb
doaj   +1 more source