Results 91 to 100 of about 175 (106)

Hairpin conformation of amphidinols possibly accounting for potent membrane permeabilizing activities

Tetrahedron, 2005
Amphidinols are a unique dinoflagellate metabolite with potent antifungal activity. We examined membrane permeabilizing action by amphidinol analogues with structural variations in polyhydroxy and polyene moieties. Consequently, the polyene and polyhydroxy moieties turned out to play important roles in binding to lipid bilayer membrane and in forming ...
Toshihiro Houdai, Shigeru Matsuoka, Nagy Morsy, Nobuaki Matsumori, Masayuki Satake, Michio Murata   +5 more
openaire   +1 more source

Membrane permeabilizing action of amphidinol 3 and theonellamide A in raft-forming lipid mixtures

Zeitschrift für Naturforschung C, 2016
Abstract Amphidinol 3 (AM3) and theonellamide A (TNM-A) are potent antifungal compounds produced by the dinoflagellate Amphidinium klebsii and the sponge Theonella spp., respectively. Both of these metabolites have been demonstrated to interact with membrane lipids ultimately resulting in a compromised bilayer integrity.
openaire   +2 more sources

Synthesis and Structure–Activity Relationship Studies of Truncated Artificial Analogues of Amphidinol 3

Chemistry – An Asian Journal
Abstract Structure–activity relationship studies of artificial analogues of amphidinol 3 (AM3) were conducted. Based on the truncated molecule corresponding to the C21–C67 section of AM3, which elicited comparable antifungal activity to the parent compound, its stereoisomers were synthesized from polyol, bis‐THP, and polyene units via
Yoko Yasuno, Yuma Wakamiya, Yusuke Mita, Yuki Yamashita, Nobuaki Matsumori, Tohru Oishi   +5 more
openaire   +2 more sources

Isolation and Structural Elucidation of New Amphidinol Analogues from Amphidinium carterae Cultivated in a Pilot-Scale Photobioreactor

Marine Drugs, 2021
Asterio Sanchez Miron, Lorenzo Lopez Rosales, FRANCISCO García-Camacho   +2 more
exaly  

The structures of five new antifungal and hemolytic amphidinol analogs from Amphidinium carterae collected in New Zealand

Harmful Algae, 2005
Masayuki Satake, Yasukatsu Oshima
exaly  

Amphidinol 22, a New Cytotoxic and Antifungal Amphidinol from the Dinoflagellate Amphidinium carterae

Marine Drugs, 2019
Bastien Cautain, Mercedes De La Cruz Moreno, Marcel Jaspars   +2 more
exaly  

Stereoselective Synthesis of the C(53)-C(67) Polyene Fragment of Amphidinol 3

Synlett, 2007
Janine Cossy
exaly  

Synthesis of a Truncated Analog of Amphidinol 3 Corresponding to the C21–C39/C52–C67 Section

Chemistry Letters, 2017
Tohru Oishi, Yuri Takada, Makoto Ebine   +2 more
exaly  

Synthesis of an Analog of Amphidinol 3 Corresponding to the C31–C67 Section

HETEROCYCLES, 2018
Tohru Oishi, Tomoyuki Koge, Makoto Ebine
openaire   +1 more source

Sterol effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance

Bioorganic and Medicinal Chemistry Letters, 2010
Michio Murata, Tohru Oishi, Nobuaki Matsumori   +2 more
exaly