Results 81 to 90 of about 175 (106)
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Syntheses of C22–C29 and C20–C29 sections of amphidinol 3
Tetrahedron LettersYoko Yasuno, Tohru Oishi
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Diastereoselective synthesis of the C14–C29 fragment of amphidinol 3
Organic & Biomolecular Chemistry, 2013An efficient stereoselective synthesis of the C14–C29 fragment highlighting a coupling reaction between a 1,3-dithiane derivative and an α-branched aldehyde was realized. This highly convergent synthesis involved two chiral pools, L-malic acid and (+)-camphorsulfonic acid, which are the starting compounds to control the six stereogenic centers present ...
Rival, Nicolas +5 more
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Stereoselective Synthesis of the C31−C40/C43−C52 Unit of Amphidinol 3
The Journal of Organic Chemistry, 2009A concise synthesis of a tetrahydropyran ring system corresponding to the C31-C40 and C43-C52 units of amphidinol 3 is described. Successive chemoselective reactions, i.e., cross-metathesis to differentiate the iodoolefin from the terminal olefin and Sharpless asymmetric dihydroxylation on the resulting E-olefin, resulted in expeditious synthesis of an
Mitsunori, Kanemoto +2 more
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Development of an Access Route to the C31−C52 Central Core of Amphidinol 3
Organic Letters, 2007[reaction: see text] An asymmetric synthesis of the heavily oxygenated inner sector of amphidinol 3 constituted of C31-C52 is described. The successful pathway highlights construction of the pair of identical tetrahydropyran subunits from a common intermediate.
Matthew W, Bedore +2 more
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Toxicon, 2007
The cytotoxicity of lingshuiol, a novel polyhydroxy compound with a linear carbon-chain isolated from the cultured marine dinoflagellate Amphidinium sp., and that of amphidinol 2 (AM2) was compared with hepatocytes. Both lingshuiol and AM2 were toxic to primary rat hepatocytes with IC(50) values of 0.21 and 6.4muM, respectively.
Xin-Ming, Qi +5 more
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The cytotoxicity of lingshuiol, a novel polyhydroxy compound with a linear carbon-chain isolated from the cultured marine dinoflagellate Amphidinium sp., and that of amphidinol 2 (AM2) was compared with hepatocytes. Both lingshuiol and AM2 were toxic to primary rat hepatocytes with IC(50) values of 0.21 and 6.4muM, respectively.
Xin-Ming, Qi +5 more
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Stereoselective Synthesis of the C(1) - C(28) Fragment of Amphidinol 3
Helvetica Chimica Acta, 2016Jhillu Singh Yadav
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Bioorganic & Medicinal Chemistry, 2006
Two new homologues of amphidinols (AM14 and AM15) were isolated from the cultured dinoflagellate Amphidinium klebsii. The structures were elucidated on the basis of 2D NMR and collision-induced dissociation MS/MS and turned out to be closely related homologues of AM7.
Nagy, Morsy +8 more
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Two new homologues of amphidinols (AM14 and AM15) were isolated from the cultured dinoflagellate Amphidinium klebsii. The structures were elucidated on the basis of 2D NMR and collision-induced dissociation MS/MS and turned out to be closely related homologues of AM7.
Nagy, Morsy +8 more
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Diastereoselective synthesis of the C14–C29 fragment of amphidinol.
Organic & biomolecular chemistry, 2014An efficient stereoselective synthesis of the C14–C29 fragment highlighting a coupling reaction between a 1,3-dithiane derivative and an α-branched aldehyde was realized. This highly convergent synthesis involved two chiral pools, L-malic acid and (+)-camphorsulfonic acid, which are the starting compounds to control the six stereogenic centers present ...
Nicolas, Rival +5 more
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Structure and Biosynthesis of Amphidinol 17, a Hemolytic Compound from Amphidinium carterae
Journal of Natural Products, 2010Amphidinol 17 (AM17; 1), a novel amphidinol, has been isolated from a Bahamas strain of Amphidinium carterae. This new congener contains the signature hairpin region and a Delta(6) polyene arm, whereas the polyol arm is distinct from those of other amphidinols.
Yanhui, Meng +4 more
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Acetate labeling patterns of dinoflagellate polyketides, amphidinols 2, 3 and 4
Tetrahedron, 2001Abstract Amphidinols, which are polyketide metabolites chiefly comprising a long linear chain with polyhydroxyl groups and polyolefins, are produced by marine dinoflagellates Amphidinium carterae and A. klebsii. The acetate incorporation experiments of amphidinols 2, 3 and 4 revealed that they are built up with five regular C2-elongation sequences ...
Toshihiro Houdai +6 more
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