Mitomycin C Induces Autophagy in Human Tracheal Fibroblasts and Suppresses Their Growth
Mitomycin C (MMC) selectively inhibits the proliferation of human tracheal fibroblasts (hTF) more effectively than human tracheal epithelial cells (hTEC), with hTF showing a dose‐ and time‐dependent sensitivity to MMC treatment. Additionally, MMC induces autophagy in hTF, as evidenced by increased expression of autophagy markers, while suppressing cell
Jeong‐Mi Kim +5 more
wiley +1 more source
In Vitro Antifungal Activity of Amphotericin B-Encapsulated Silk Fibroin-Chitosan Nanoparticles Against <i>Fusarium solani</i> Isolates from Keratitis Patients. [PDF]
Khotcharrat R +3 more
europepmc +1 more source
A series of azomethine‐pyrazole derivatives bearing a para‐substituted azo‐phenyl ring is straightforwardly prepared. The new compounds display an elevated antifungal activity against various Candida species and Cryptococcus neoformans strains. DFT and molecular docking calculations are used to determine possible routes of action through interactions ...
María Isabel Murillo +8 more
wiley +1 more source
Genome analyses of amphotericin B-susceptible and -resistant strains of <i>Leishmania</i> (<i>Mundinia</i>) <i>martiniquensis</i> reveal variations potentially related to amphotericin B resistance. [PDF]
Jariyapan N +11 more
europepmc +1 more source
ABSTRACT Clostridioides difficile infection (CDI) represents a significant health risk to pediatric stem cell transplant (SCT) patients. In these patients, recurrent CDI is common, requiring prolonged antibiotic usage and increased hospitalization. Bezlotoxumab, a monoclonal antibody that targets the toxin responsible for CDI, has demonstrated efficacy
Aaron E. Fan +8 more
wiley +1 more source
In Vitro Efficacy and Toxicity Assessment of an Amphotericin B Gel for the Treatment of Cutaneous Leishmaniasis. [PDF]
Sosa L +7 more
europepmc +1 more source
ABSTRACT Introduction Pulmonary complications due to infection contribute significantly to post‐haematopoietic stem cell transplant (HCT) morbidity and mortality. Standard microbiological investigations, when performed on bronchoalveolar lavage (BAL) fluid, can take days to weeks to confirm a diagnosis.
Hannah Walker +8 more
wiley +1 more source
Combination of isobavachalcone and amphotericin B has antifungal effect against <i>Cryptococcus neoformans</i> and protects host tissue damage by inhibiting ferroptosis. [PDF]
Qian W +5 more
europepmc +1 more source

