Results 321 to 330 of about 13,097,347 (378)

Hyperglycemia Aggravates 6‐Hydroxydopamine‐Induced Neuronal Ferroptosis via SLC7A11‐Dependent Pathway in Diabetic PD Rat Model

CNS Neuroscience &Therapeutics, Volume 31, Issue 7, July 2025.
Chronic hyperglycemia disrupts the cystine/SLC7A11/glutathione axis, impairing cystine uptake and depleting glutathione in dopaminergic neurons, increasing ferroptosis susceptibility. SLC7A11 restoration rescues neuronal viability, restores redox balance, and attenuates neurodegeneration in diabetic PD models. SLC7A11 emerges as a therapeutic target to
Ya Zhao, Dan Wang, Yanwei Wang, Dan Mu, Lang Qu, Rong Li   +5 more
wiley   +1 more source

Effect of light‐cured pulp capping materials on human dental pulp cells in vitro

International Endodontic Journal, Volume 58, Issue 7, Page 1060-1072, July 2025.
Abstract Aim Gold standard as material in vital pulp therapy (VPT) is hydraulic calcium silicate cements (HCSC). To circumvent their prolonged setting time, light‐cured pulp capping materials containing calcium silicate or calcium hydroxide powder are available.
Laurentia Schuster, Sonja Sielker, Johannes Kleinheinz, Till Dammaschke   +3 more
wiley   +1 more source

Multi-Omics Analysis of Experimentally Evolved Candida auris Isolates Reveals Modulation of Sterols, Sphingolipids, and Oxidative Stress in Acquired Amphotericin B Resistance. [PDF]

Mol Microbiol
Chauhan A, Carolus H, Sofras D, Kumar M, Kumar P, Nair R, Narayanan A, Yadav K, Ali B, Biriukov V, Saini A, Leaves I, Vergauwen R, Romero CL, Malavia-Jones D, Singh A, Banerjee A, Rudramurthy SM, Chakrabarti A, Mondal AK, Gaur NA, Sanyal K, Rybak JM, Gabaldón T, Van Dijck P, Gow NAR, Prasad R.   +26 more
europepmc   +1 more source

Cannabidiol Is a Potential Inhibitor of Ferroptosis in Human Articular Chondrocytes

Journal of Cellular and Molecular Medicine, Volume 29, Issue 13, July 2025.
ABSTRACT The present study investigates the effects of cannabidiol (CBD), the major non‐psychoactive compound of Cannabis sativa L. extracts, on ferroptotic cell death in human articular chondrocytes. Exposure to known ferroptosis inducers RSL3, erastin and its analogue IKE, FINO2 and FIN56 led to a varying extent of reduced cell viability in two ...
A. Wipplinger, D. Bekric, C. Ablinger, M. Kittl, C. Mayr, M. Ritter, M. Winklmayr, M. Jakab   +7 more
wiley   +1 more source

Investigation of urinary miRNA profile changes in amphotericin B-induced nephrotoxicity in C57BL/6 mouse, Sprague-Dawley rats and Beagle dogs. [PDF]

Toxicol Sci
Adedeji AO, Tackett MR, Tejada G, McDuffie JE.   +3 more
europepmc   +1 more source

Immunological Responses to Tetanus and Influenza Vaccination in Donkeys

Journal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.
ABSTRACT Background Donkeys are routinely vaccinated with protocols developed for horses, yet species‐specific data on their immune responses are limited. Hypothesis/Objectives We hypothesized that donkeys exhibit robust T‐cell‐mediated immunity and regulatory adaptation after vaccination, comparable to horses.
Maciej Perzyna, Jowita Grzędzicka, Dominika Milczek‐Haduch, Izabela Dąbrowska, Michał Trela, Bartosz Pawliński, Olga Witkowska‐Piłaszewicz   +6 more
wiley   +1 more source

<i>Aspergillus terreus</i> sectorization: a morphological phenomenon shedding light on amphotericin B resistance mechanism. [PDF]

mBio
Eisele D, Blatzer M, Dietl AM, Binder U, Müller C, Hagen F, Sae-Ong T, Schäuble S, Panagiotou G, Vahedi-Shahandashti R, Lass-Flörl C.   +10 more
europepmc   +1 more source

Antibiofilm activity of manogepix, ibrexafungerp, amphotericin B, rezafungin, and caspofungin against <i>Candida</i> spp. biofilms of reference and clinical strains. [PDF]

Antimicrob Agents Chemother
Ceballos-Garzon A, Lebrat J, Holzapfel M, Josa DF, Welsch J, Mercer D.   +5 more
europepmc   +1 more source

Efficacy, Safety, and Cost-Effectiveness of N-Acetylcysteine in Preventing Amphotericin B Nephrotoxicity in Egyptian Patients with Hematological Malignancies: A Randomized Controlled Trial. [PDF]

Hosp Pharm
Ebid AIM, Mohamed HS, Mohammed YMM, Mohamed Abdel Motaleb SM.   +3 more
europepmc   +1 more source