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Amphotericin B Encapsulation in Polymeric Nanoparticles: Toxicity Insights via Cells and Zebrafish Embryo Testing. [PDF]

open access: yesPharmaceutics
Maciel-Magalhães M   +10 more
europepmc   +1 more source
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Amphotericin B

Applied Microbiology and Biotechnology, 2005
Invasive fungal infections are a major cause of morbidity and mortality in immunodeficient individuals (such as AIDS patients) and in transplant recipients or tumor patients undergoing immunosuppressive chemotherapy. Amphotericin B is one of the oldest, yet most efficient antimycotic agents. However, its usefulness is limited due to dose-dependent side-
Lemke, A.   +2 more
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Amphotericin B and Coccidioidomycosis

Annals of the New York Academy of Sciences, 2007
Abstract:  Prior to the 1950s no effective therapy for coccidioidomycosis existed. The advent of amphotericin B ushered in the therapeutic era for coccidioidomycosis. Until this time amphotericin B and its lipid congeners have been regarded as the “gold standard” of therapy for severe pulmonary and disseminated coccidioidomycosis.
Royce H. Johnson, Hans E. Einstein
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Amphotericin B

Pediatrics In Review, 1995
There are many circumstances in which pediatricians today may be involved in the care of patients at risk for systemic fungal infection. Among those at risk are children receiving chemotherapy for neoplastic disease, children infected with human immunodeficiency virus (HIV), and children undergoing immunosuppressive therapy for chronic illnesses or ...
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Amphotericin B and Maduromycosis

Archives of Pediatrics & Adolescent Medicine, 1978
Sir .—Let me react to the clinical memorandum on the treatment of Maduromycosis with amphotericin B by Hayden et al in theJournal(131:927, 1977). We would point out that our case, to which they refer in their third reference, also had "apparent remission," but recurred thereafter.
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Amphotericin B Nephrotoxicity

Drug Safety, 1990
The frequency of fungal infections is increasing. Amphotericin B remains the anti-fungal drug of choice for most systemic infections, but a limiting factor for its use is the development of nephrotoxicity. Amphotericin B-induced nephrotoxicity is manifested as azotaemia, renal tubular acidosis, impaired renal concentrating ability and electrolyte ...
Ramzi Sabra, Robert A. Branch
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Amphotericin B

2003
Abstract Amphotericin B has been the cornerstone of antifungal therapy for almost 50 years. Discovered in the late 1950s, it was approved for human use as an antimycotic in 1960. Initial formulations of amphotericin B were plagued with impurities.
Stanley W Chapman   +2 more
openaire   +1 more source

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