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Amphotericin B: an introduction
Journal of Antimicrobial Chemotherapy, 1991Amphotericin B has a broad spectrum of action that includes most of the major fungal pathogens of man. This drug binds to the membrane sterols of fungal cells, causing impairment of their barrier function and loss of cell constituents. Metabolic disruption and cell death are consequent upon membrane alterations.
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The lipid formulations of amphotericin B
Expert Opinion on Pharmacotherapy, 2003Amphotericin B spectrum covers most of the fungal pathogens involved in human diseases. Its use is limited by infusion-related effects and nephrotoxicity. As a result of strong lipophilic properties, encapsulation in liposomes or binding to lipid complexes led to the development of lipid formulations in an attempt to increase both efficacy and safety ...
Shanti Natarajan-Amé +3 more
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Journal of Antimicrobial Chemotherapy, 2002
Abstract The use of amphotericin B limited by dose-dependent nephrotoxicity. Elevated creatinine associated with amphotericin B is not only a marker for renal dysfunction, but is also linked to an increase in hospital costs and a substantial risk for the use of haemodialysis and a higher mortality rate.
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Abstract The use of amphotericin B limited by dose-dependent nephrotoxicity. Elevated creatinine associated with amphotericin B is not only a marker for renal dysfunction, but is also linked to an increase in hospital costs and a substantial risk for the use of haemodialysis and a higher mortality rate.
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Amphotericin B‐associated leukoencephalopathy
Neurology, 1992We report instances of fatal leukoencephalopathy associated with the intravenous administration of the antifungal agent amphotericin B (AmB) to a 16-year-old girl treated for acute lymphoblastic leukemia and a 22-year-old man who underwent bone marrow transplantation for a myelodysplastic syndrome.
Russell W. Walker, Marc K. Rosenblum
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Amphotericin B — Not So Terrible
Annals of Pharmacotherapy, 2001OBJECTIVE: To describe a patient who developed adverse reactions to two different lipid formulations of amphotericin B: liposomal amphotericin B (AmBisome) and amphotericin B colloidal dispersion (ABCD, Amphocil), yet tolerated amphotericin B deoxycholate (Fungizone) despite renal toxicity.
Silvio Pitlik +3 more
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GIVING AMPHOTERICIN B IN THE HOME
AJN, American Journal of Nursing, 1988Carolyn Sipes, RN, MSN, formerly director, patient care services, Harmony Home Health of Mercy Center, Aurora, IL, currently works at RushPresbyterian-St. Luke's Medical Center in Chicago. daily, the patient must be able to hook up his own infusion before discharge from the hospital.
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Annals of Pharmacotherapy, 2006
Objective: To report the clinical course of a woman with cryptococcal meningitis and no previous cardiac disease who developed a fatal cardiac arrhythmia after an acute overdose of amphotericin B and to review its toxicity. Case Summary: A 41-year-old woman with a history of proliferative glomerulonephritis from systemic lupus erythematosus was ...
John R Foringer +4 more
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Objective: To report the clinical course of a woman with cryptococcal meningitis and no previous cardiac disease who developed a fatal cardiac arrhythmia after an acute overdose of amphotericin B and to review its toxicity. Case Summary: A 41-year-old woman with a history of proliferative glomerulonephritis from systemic lupus erythematosus was ...
John R Foringer +4 more
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Intravitreal Amphotericin B Toxicity
American Journal of Ophthalmology, 1974The outcome of the occasional case of postsurgical, posttraumatic, or endogenous mycotic endophthalmitis is generally poor. In those cases in which the focus of infection is localized in the vitreous cavity, direct injec tion of an antimicrobial agent into the vitre ous may be a rational approach. The use of effective levels of amphotericin B against
W. Richard Green, Elias N. Souri
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Amphotericin B and Blastomycosis
Southern Medical Journal, 1978Charles V. Sanders, Richard N. Greenberg
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