Results 211 to 220 of about 348,393 (352)

Urea Biosensor Based on a Field‐Effect Capacitor Modified With a Stacked Weak Polyelectrolyte/Enzyme Bilayer

open access: yesElectrochemical Science Advances, EarlyView.
ABSTRACT Urea is formed from the metabolism of proteins and used as a biomarker for diagnosing and monitoring various medical conditions. In this work, a urea biosensor based on an electrolyte‐insulator‐semiconductor capacitor (EISCAP) modified with a stacked polyelectrolyte polyallylamine hydrochloride (PAH)/urease bilayer prepared by the layer‐by ...
Astghik S. Tsokolakyan   +7 more
wiley   +1 more source

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine‐guanine‐phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes.
Alina Göpfert   +5 more
wiley   +1 more source

Global Stress Responses Identify the Functionally Divergent Regulators Required for Candida auris Commensalism and Pathogenicity

open access: yesExploration, EarlyView.
Candida auris is an emerging multidrug‐resistant fungal pathogen that poses a serious global health threat. In our study, we comprehensively delineate both the pan‐genomic and transcriptomic features of C. auris. Intriguingly, our findings reveal an unexpected alkaline pH‐dependent regulation required for C. auris virulence and commensalism mediated by
Chaoyue Xu   +30 more
wiley   +1 more source

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