Results 201 to 210 of about 1,079,858 (266)

Threonine 348 regulates the subcellular localization of PTEN

open access: yesFEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Molecular engineering of CRISPR/Cas12a: from activity enhancement to exponential signal amplification. [PDF]

open access: yesChem Sci
Li QN   +9 more
europepmc   +1 more source
Some of the next articles are maybe not open access.

Limits to amplification

Electrical Engineering, 1934
The amplification obtainable in a vacuum tube amplifier is limited by the noise in the circuit. Of the various sources of noise the most fundamental and inevitable is thermal agitation of electricity. Other sources are the influence of ions and of shot effect and flicker effect on the current in vacuum tubes, poor contacts, mechanical vibration, and ...
J. B. Johnson, F. B. Llewellyn
openaire   +1 more source

Synchrony amplification

2012 IEEE International Symposium on Information Theory Proceedings, 2012
Various protocols in the cryptography and distributed systems literature assume some notion of time: One major (but not the only) example are "synchronous" models which assume that a protocol is executed in a well defined sequence of rounds with round switches that occur (almost) simultaneously at the parties.
Maurer Ueli, Tackmann Björn
openaire   +1 more source

DNA Amplification

Immunological Investigations, 1997
The polymerase chain reaction has become a mainstream tool for the molecular biologist. The sensitivity, efficiency, and speed of this method is unparalleled for the amplification and detection of exquisitely minute quantities of nucleic acids. Through repetitive cycles of heat denaturation of samples, followed by the base pairing of primers designed ...
openaire   +2 more sources

Adaptive Amplification

Critical Reviews in Biochemistry and Molecular Biology, 2007
Modern techniques are revealing that repetition of segments of the genome, called amplification or gene amplification, is very common. Amplification is found in all domains of life, and occurs under conditions where enhanced expression of the amplified genes is advantageous.
openaire   +2 more sources

Amplification by compartmentalization

Nature, 2002
Autocatalysis and chemical amplification are properties of living systems that can lead to increased responsiveness and to self-replication. Here we describe a synthetic system in which a unique form of reagent compartmentalization gives rise to nonlinear kinetics that are subject to the precise size- and shape-selectivity of the host.
Jian, Chen   +4 more
openaire   +2 more sources

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