Results 231 to 240 of about 2,067,066 (317)

Cellular Heterogeneity in Drug Uptake Amplifies Pharmacodynamic Variability: A Stochastic PK-PD Analysis. [PDF]

CPT Pharmacometrics Syst Pharmacol
Duong NH, Do TN, Nguyen TT, Phan KQ, Nguyen LT.   +4 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Development of a Closed One-Tube Colorimetric and Fluorescent LAMP Assay for the Rapid Detection of Feline Herpesvirus 1. [PDF]

Animals (Basel)
Yi S, Zhao H, Huang X, Yu J, Sha W, Lian W, Niu J, Yin B.   +7 more
europepmc   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

A Centrifugal Microfluidic Platform Integrating Immunomagnetic Separation and Isothermal Amplification for Rapid and High-Sensitivity Detection of Foodborne Pathogens. [PDF]

Biosensors (Basel)
Zheng Q, Zhuang Z, Lei H, Lin J, Yang H, Hu R.   +5 more
europepmc   +1 more source

Evidence linking Arctic amplification to extreme weather in mid‐latitudes

, 2012
J. Francis, S. Vavrus
semanticscholar   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Development of nucleic acid testing technology for quarantine pest <i>Globodera rostochiensis</i> based on a species-specific DNA fragment. [PDF]

PeerJ
Lan F, Li H, Yin Z, Wang Y, Liu X, Yang J, Sun Y, Tang Y, Wang B, Yin S, Li B, Tao X.   +11 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Fragmentation of Long Reads Enables Reliable Mitogenome Assembly From Whole-Genome Amplification Data With Pervasive Palindromic Reads. [PDF]

Mol Ecol Resour
Vecchi M, Surmacz B, Jönsson IK, Stec D.   +3 more
europepmc   +1 more source