Results 41 to 50 of about 1,381,260 (252)
OncoImmunology, 2017 Soft-tissue sarcomas (STS) are rare malignancies that account for 1% of adult cancers and comprise more than 50 entities. Current therapeutic options for advanced-stage STS are limited. Immune checkpoint inhibitors targeting the PD-1/PD-L1 signaling axis
Jan Budczies +19 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
JGE, 2023 Desa Jati Mulyo berada di Kecamatan Dendang Kabupaten Tanjung Jabung Timur yang didominasi oleh gambut sehingga rentan terhadap penurunan muka tanah.
Iwilja Nanda Risa +2 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The amplification effect of El Niño on winter heavy pollution frequency in Beijing
Environmental Research LettersChina has implemented stringent emission controls to reduce PM _2.5 pollution, but the impact of the El Niño-Southern Oscillation (ENSO) on regional heavy pollution events in this process remains understudied. We use the WRF-SMOKE-CMAQ modeling system to
Mengjie Lou +6 more
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Loop-mediated isothermal amplification (LAMP) test for detection of Trypanosoma evansi strain B [PDF]
, 2010 Camel Trypanosomiasis (Surra) is mainly caused by Trypanosoma evansi strains that express variable surface glycoprotein (VSG) RoTat 1.2 However, in Kenya a second causative strain that does not express RoTat 1.2 VSG (T. evansi type B) has been identified.
Njiru, Z.K. +3 more
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Sex determining region Y-box 2 (SOX2) amplification is an independent indicator of disease recurrence in sinonasal cancer. [PDF]
, 2013 The transcription factor SOX2 (3q26.3-q27) is an embryonic stem cell factor contributing to the induction of pluripotency in terminally differentiated somatic cells.
Friedrich Bootz +29 more
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An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
AMPLIFICATION AS A MEANS OF INTENSIFYING POETIC EXPRESSIVENESS OF SPEECH
Sovremennye Issledovaniâ Socialʹnyh Problem, 2023 Purpose. This article is devoted to the consideration of amplification as an expressive means of stylistic syntax in the texts of the German Romantics of the 19th century.
Natalja N. Chaiko
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Polymerase-endonuclease amplification reaction for large-scale enzymatic production of antisense oligonucleotide [PDF]
, 2009 Synthetic oligonucleotides are contaminated with highly homologous failure sequences. Oligonucleotide synthesis is difficult to scale up because it requires expensive equipments, hazardous chemicals, and tedious purification process.
Deming Gou, Xiaolong Wang
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