Results 131 to 140 of about 239,760 (319)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

All-optical phase regeneration of 40Gbit/s DPSK signals in a black-box phase sensitive amplifier

We present a black-box four wave mixing based bit-rate-flexible phase sensitive amplifier and use it in the first demonstration of 40 Gbit/s DPSK phase ...
Syvridis, D., Ellis, A.D., Jakobsen, D., Petropoulos, P., O'Gorman, J., Richardson, D.J., Grüner-Nielsen, L., Kakande, J., Weerasuriya, R., Bogris, A., Sygletos, S., Dasgupta, S., Parmigiani, F., Slavík, R., Herstrøm, S., Andrekson, P., Sjödin, M., Lundström, C., Phelan, R.   +18 more
core  

A class B switch-mode assisted linear amplifier

, 2003
A switch-mode assisted linear amplifier (SMALA) combining a linear (Class B) and a switch-mode (Class D) amplifier is presented. The usual single hysteretic controlled half-bridge current dumping stage is replaced by two parallel buck converter stages ...
Geoffrey R. Walker, Walker, G. R., Walker, G.R.   +2 more
core   +1 more source

Estimating the Reliability and Sensitivity of a Public Address System Through the Markov Decision Process

Telecom
This research aims to evaluate the reliability indices of a public address system (PAS) through the Markovian approach. Many organizations and businesses use this system to address or broadcast a message or pass on important information to the huge ...
Pardeep Kumar, Amit Kumar
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Capacitive Sensor System for Measuring Moisture Content in Transformer Oil

Electrical Engineering and Energy
The efficiency and long-term reliability of electrical transformers are highly dependent on the quality of their insulating oil, which serves both as a dielectric medium and a cooling agent.
Rustam Baratov Jalilovich, Khurshid Sattarov, Mashrab Abdullayev Xamro Ugli, Almardon Mustafoqulov Mamatovich   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Brightness enhancement limits in pulsed cladding pumped fiber Raman amplifiers

We analyze theoretically limitations on the brightness enhancement of a multimode pump beam, to be efficiently converted into a diffraction-limited Stokes beam in a cladding-pumped fiber Raman amplifier.
Nilsson, Johan, Codemard, Christophe A., Ji, Junhua   +2 more
core   +1 more source