Results 111 to 120 of about 395,124 (322)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Power Scaling Laws of Massive MIMO Full-Duplex Relaying With Hardware Impairments

open access: yesIEEE Access, 2018
This paper considers a massive MIMO full-duplex relaying (FDR) system, in which multiple single-antenna sources simultaneously communicate with multiple single-antenna destinations using a single relay that is equipped with Ntx transmit antennas and Nrx ...
Si-Nian Jin, Dian-Wu Yue, Ha H. Nguyen
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Multiple Access Channels With Full-Duplex Amplify-and-Forward Transmitter Cooperations

open access: yesIEEE Access, 2019
In this paper, a full-duplex (FD) transmitter cooperative scheme is proposed to improve the achievable rate for multiple access channels (MACs). In the proposed scheme, by leveraging the FD amplify-and-forward (AF) protocol, two FD transmitters send ...
Qingpeng Liang, Donglin Liu, Chuan Huang
doaj   +1 more source

Exact Outage Performance Analysis of Amplify-and-forward-aware Cooperative NOMA

open access: yesTELKOMNIKA (Telecommunication Computing Electronics and Control), 2018
In this paper, new radio access scheme that combines Amplify-and-Forward (AF) relaying protocol and non-orthogonal multiple access (NOMA) system is introduced. In particular, different scenarios for fixed power allocation scheme is investigated.
D. Do, T. Nguyen
semanticscholar   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

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