Results 51 to 60 of about 731,929 (298)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Directional amplitude backscatter modulation with suppressed Doppler based on rotating resonant loop [PDF]
, 2022 Ashkan Azarfar +2 more
openalex +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Faster amplitude estimation [PDF]
Quantum Information and Computation, 2020 In this paper, we introduce an efficient algorithm for the quantum amplitude estimation task which is tailored for near-term quantum computers. The quantum amplitude estimation is an important problem which has various applications in fields such as quantum chemistry, machine learning, and finance.
openaire +2 more sources
Scalar-graviton amplitudes [PDF]
Journal of High Energy Physics, 2019 Abstract Using the CHY-formalism and its extension to a double cover we provide covariant expressions for tree-level amplitudes with two massive scalar legs and an arbitrary number of gravitons in D dimensions. Using unitarity methods, such amplitudes are needed inputs for the computation of post-Newtonian and post-Minkowskian ...
Bjerrum-Bohr, N. E. J. +3 more
openaire +6 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Periods and Amplitudes of Southern Pine Beetle Infestations under Climate Change [PDF]
, 2022 Hyunjin An, Jianbang Gan
openalex +1 more source
IEEE Access, 2021 This paper proposes a varactor-based circuit technique intended for amplitude and phase control, with improved linearity in the presence of parasitic capacitances and parasitic inductances.
David Berthiaume +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source