Results 61 to 70 of about 2,588,382 (336)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Geometry in scattering amplitudes

Physical Review D, 2022
We formulate the field-space geometry for an effective field theory of scalars and gauge bosons. Geometric invariants such as the field-space curvature enter in both scattering amplitudes and the renormalization group equations, with the scalar and gauge results unified in a single expression.
Andreas Helset, Elizabeth E. Jenkins, Aneesh V. Manohar   +2 more
openaire   +4 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Dual picosecond fast tunable optical parametric amplifier laser system for wide-field nonlinear optical microscopy

APL Photonics
In the last decades, nonlinear optical microscopy techniques, such as two-Photon Excited Fluorescence (2PEF), Sum Frequency Generation (SFG), and Hyperspectral Coherent Anti-Stokes Raman Scattering (H-CARS) microscopy, emerged as powerful tools to image ...
Federico Vernuccio, Assia Benachir, Eric Michele Fantuzzi, Benoit Morel, Simone Bux, Erwann Martin, José Villanueva, Yoann Pertot, Nicolas Thiré, Sandro Heuke, Hervé Rigneault   +10 more
doaj   +1 more source

Vascular response to the microcirculation in the fingertip by local vibration with varied amplitude

Frontiers in Bioengineering and Biotechnology, 2023
Objectives: We investigated the effect of local vibration intensity on the vascular response to the microcirculation of the finger.Materials and methods: We performed hand-transmitted vibration experiments combined with laser Doppler flowmetry (LDF) to ...
Lizhong Mu, Lizhong Mu, Aoran Sun, Youqiang Chen, Huimin Chen, Jianda Li, Bingqi Linghu, Hang Zhou, Qingzhuo Chi, Xiaofeng Luan, Yue Pan   +10 more
doaj   +1 more source

M5-brane amplitudes [PDF]

Journal of Physics A: Mathematical and Theoretical, 2020
The dynamics of a probe M5-brane, embedded as a hypersurface in eleven-dimensional Minkowski spacetime, is described by a six-dimensional world-volume theory. This theory has a variety of interesting symmetries some of which are obscure in the Lagrangian formulation of the theory.
openaire   +6 more sources

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Femtosecond Laser Percussion Drilling of Silicon Using Repetitive Single Pulse, MHz-, and GHz-Burst Regimes

Micromachines
In this contribution, we present novel results on top-down drilling in silicon, the most important semiconductor material, focusing specifically on the influence of the laser parameters.
Pierre Balage, Manon Lafargue, Théo Guilberteau, Guillaume Bonamis, Clemens Hönninger, John Lopez, Inka Manek-Hönninger   +6 more
doaj   +1 more source

Pengaruh Variasi Agregat Kasar Penyusun Beton Terhadap Kerapatan Beton Dengan Menggunakan Transmission Time Pada Alat UPV (Ultrasonic Pulse Velocity)

Rekayasa Sipil, 2019
To find out the quality of concrete, we need to test the concrete. Which is non destructive test or testing without damaging the test object, namely with an UPV (Ultrasonic Pulse Velocity). In this study using 4 variations of coarse aggregate composition
Fatma Dora Indriani, Christin Remayanti Nainggolan, Ming Narto wijaya   +2 more
doaj   +1 more source

Optical Analysis of the Impact Transmission in Steel Sheet Arrays with Bolted-Type Joints

Applied Sciences, 2023
This research leads with the analysis of a structural joint. Different arrays of steel sheets were joined using bolts. The structures were built in a metallic box filled with Granitic 0/3 sand.
Víctor Martínez-Calzada, Felipe de Jesús Tapia-Pérez, Adriana Rodríguez-Torres, Alonso Saldaña-Heredia   +3 more
doaj   +1 more source