Results 51 to 60 of about 29,731 (231)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Dynamic changes of amplitude of low‐frequency fluctuations in patients with generalized anxiety disorder [PDF]

Human Brain Mapping, 2019
AbstractPrevious neuroimaging studies have mainly focused on alterations of static and dynamic functional connectivity in patients with generalized anxiety disorder (GAD). However, the characteristics of local brain activity over time in GAD are poorly understood.
Qian Cui, Wei Sheng, Yuyan Chen, Yajing Pang, Fengmei Lu, Qin Tang, Shaoqiang Han, Qian Shen, Yifeng Wang, Ailing Xie, Jing Huang, Di Li, Ting Lei, Zongling He, Huafu Chen   +14 more
openaire   +2 more sources

Altered Temporal Dynamics of the Amplitude of Low-Frequency Fluctuations in Comitant Exotropia Patients

Frontiers in Human Neuroscience, 2022
PurposeGrowing evidence reported that patients with comitant exotropia (CE) were accompanied by static cerebral neural activity changes. However, whether the dynamic time-varying of neural activity changes in patients with CE remains unknown.MethodsA total of 36 patients with CE (25 men and 11 women) and 36 well-matched healthy controls are enrolled in
Ri-Bo Chen, Shu-Yuan Ye, Chong-Gang Pei, Yu-Lin Zhong   +3 more
openaire   +3 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Regional amplitude of the low-frequency fluctuations at rest predicts word-reading skill

Neuroscience, 2015
Individuals' reading skills are critical for their educational development, but variation in reading skills is known to be large. The present study used functional magnetic resonance imaging (fMRI) to examine the role of spontaneous brain activity at rest in individual differences in reading skills in a large sample of participants (N=263 ...
Xu, M., Beuckelaer, A. de, Wang, X, Liu, L., Song, Y., Liu, J.   +5 more
openaire   +3 more sources

Changes in the Amplitude of Low-Frequency Fluctuation in Patients With Lifelong Premature Ejaculation by Resting-State Functional MRI

Sexual Medicine, 2021
Introduction: Dapoxetine is considered a first-line treatment for patients with lifelong premature ejaculation (PE), and current researches have showed with functional magnetic resonance imaging (fMRI) that patients with lifelong PE might have abnormal ...
Ma Yubo, PhD, Huang Lianjia, MD, Mao Cuiping, PhD, Zhang Liandong, PhD, Liu Le, MD, Shi Meijuan, MD, Wang Ziming, PhD, Hu Xintao, PhD, Zhao Jun, PhD   +8 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Alterations of amplitude of low-frequency fluctuation in treatment-resistant versus non-treatment-resistant depression patients

Neuropsychiatric Disease and Treatment, 2019
Aixia Zhang,1,2 Gaizhi Li,1 Chunxia Yang,1 Penghong Liu,2 Yanfang Wang,1 Lijun Kang,2 Yuchen Wang,2 Kerang Zhang11Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan 030001, People’s Republic of China; 2Shanxi ...
Zhang A, Li G, Yang C, Liu P, Wang Y, Kang L, Wang Y, Zhang K   +7 more
doaj  

Sub-ionospheric very low frequency perturbations associated with the 12 May 2008 M = 7.9 Wenchuan earthquake [PDF]

Natural Hazards and Earth System Sciences, 2013
The present study reports the VLF (very low frequency) sub-ionospheric perturbations observed on transmitter JJI (22.1 kHz), Japan, received at the Indian low-latitude station, Allahabad ( geographic lat.
A. K. Maurya, R. Singh, B. Veenadhari, S. Kumar, A. K. Singh   +4 more
doaj   +1 more source