The Regulatory Repertoire of Pseudomonas aeruginosa AmpC ß-Lactamase Regulator AmpR Includes Virulence Genes [PDF]
PLoS ONE, 2012 In Enterobacteriaceae, the transcriptional regulator AmpR, a member of the LysR family, regulates the expression of a chromosomal β-lactamase AmpC.
Deepak Balasubramanian +6 more
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Role of AmpR in the High Expression of the Plasmid-Encoded AmpC β-Lactamase CFE-1 [PDF]
mSphere, 2017 CFE-1 is a unique plasmid-encoded AmpC β-lactamase with the regulator gene ampR. It imparts high resistance to most cephalosporins with constitutive high-level β-lactamase activity.
Ryuichi Nakano +3 more
doaj +5 more sources
The Role of nmcR, ampR, and ampD in the Regulation of the Class A Carbapenemase NmcA in Enterobacter ludwigii [PDF]
Frontiers in Microbiology, 2022 Various carbapenemases have been identified in the Enterobacteriaceae. However, the induction and corresponding regulator genes of carbapenemase NmcA has rarely been detected in the Enterobacter cloacae complex (ECC). The NmcA-positive isolate ECC NR1491
Ryuichi Nakano +10 more
doaj +5 more sources
Role of Low-Molecular-Mass Penicillin-Binding Proteins, NagZ and AmpR in AmpC β-lactamase Regulation of Yersinia enterocolitica [PDF]
Frontiers in Cellular and Infection Microbiology, 2017 Yersinia enterocolitica encodes a chromosomal AmpC β-lactamase under the regulation of the classical ampR-ampC system. To obtain a further understanding to the role of low-molecular-mass penicillin-binding proteins (LMM PBPs) including PBP4, PBP5, PBP6 ...
Chang Liu +11 more
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The functional repertoire of AmpR in the AmpC β-lactamase high expression and decreasing β-lactam and aminoglycosides resistance in ESBL Citrobacter freundii [PDF]
Heliyon, 2023 Citrobacter freundii is characterized by AmpC β-lactamases that develop resistance to β-lactam antibiotics. The production of extended-spectrum β-lactamase (ESBL) is substantially high in Escherichia coli, C.
Falak Naz Tariq +9 more
openalex +3 more sources
Ampicillin- and Multidrug-Resistant <i>Escherichia coli</i> and <i>Enterococcus</i> spp. in Costa Rican Wastewater and Surface Water. [PDF]
Antibiotics (Basel)Antibiotic-resistant bacteria (ARB) such as Escherichia coli and Enterococcus released into surface waters have strong potential to impact human health.
Brodrick EA +3 more
europepmc +2 more sources
A whole‐cell hypersensitive biosensor for beta‐lactams based on the AmpR‐AmpC regulatory circuit from the Antarctic Pseudomonas sp. IB20 [PDF]
Microbial BiotechnologyDetecting antibiotic residues is vital to minimize their impact. Yet, existing methods are complex and costly. Biosensors offer an alternative. While many biosensors detect various antibiotics, specific ones for beta‐lactams are lacking.
Sebastián Higuera‐Llantén +5 more
openalex +2 more sources
Efficient variant phasing utilizing a replication cycle reaction system. [PDF]
Genet Med OpenPurpose: When 2 heterozygous variants are detected in autosomal recessive disease genes, determining whether they are in cis or in trans is essential. Subcloning polymerase chain reaction products or complementary DNA is limited by variant distance (up ...
Mitsutake A +5 more
europepmc +2 more sources
Should Cefoxitin Non-Susceptibility in Ceftriaxone-Susceptible <i>E. coli</i> and <i>K. pneumoniae</i> Prompt Concerns Regarding Plasmid-Mediated AmpC Resistance? A Genomic Characterization and Summary of Treatment Challenges in Singapore. [PDF]
Antibiotics (Basel)Objectives: Plasmid-mediated AmpC beta-lactamases represent a growing clinical concern in Enterobacterales, with challenges in diagnostic approaches, limited data on clinical outcomes, and our incomplete understanding of their regulatory mechanisms ...
Foo JJ +8 more
europepmc +2 more sources
Zhongguo shiyan zhenduanxue, 2007 目的检测DHA-1型质粒AmpC酶诱导性耐药调控因子AmpR基因。方法以我院临床分离产DHA-1型质粒AmpC酶的4株大肠埃希菌和10株肺炎克雷伯菌为研究对象,采用聚合酶链反应（PCR）,用特异性引物扩增Am-pR调节因子全编码基因,并将一株肺炎克雷伯菌AmpR基因克隆到pET-22b（+）载体质粒中测序。结果所有实验菌株AmpR基因检测阳性,重组子AmpR基因测序表明与摩根摩根菌染色体上AmpR基因同源性达99.8%。结论产DHA-1型质粒AmpC酶肺炎克雷伯菌 ...
多丽波, 栾英, 张联博, 李垚
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